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Advanced Functional Nanostructured Biosensors
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Advanced Functional Nanostructured Biosensors

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (29 February 2020) | Viewed by 13411

Special Issue Editor

Prof. Dr. Valber de Albuquerque Pedrosa

E-Mail Website
Guest Editor
Institute of Bioscience, UNESP, Botucatu 18618-000, SP, Brazil
Interests: biosensors; electroanalytical; diagnostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterials have shown tremendous potential to impact the broad biological/chemical field. The unique properties of nanomaterial provide appropriate surface modifications, which allow intimate interaction with target biomolecules. The detection mechanism is based on the conversion of target binding events into physical signals that can be amplified and detected. The Special Issue “Advanced Functional Nanostructured Biosensor” aims to identify new trends of manufacturing and application of these structures in ferroelectric materials, catalytic materials, optic, magnetic, thermoelectric, piezoelectric, electrochemical, quantum dots, micro-RNA, carbon structures, and other related advanced functional materials. 
It is my pleasure to invite you to submit a manuscript to this Special Issue. Submissions of communications, full papers, and reviews are all welcome.

Prof. Dr. Valber de Albuquerque Pedrosa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanomaterials
  • Naked eye detection
  • Carbon nanotube
  • Graphene
  • Nanoplasmonic
  • Biomimetic

Published Papers (5 papers)

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Research

10 pages, 1291 KiB  
Article
Enzyme Immobilization on Maghemite Nanoparticles with Improved Catalytic Activity: An Electrochemical Study for Xanthine
by Massimiliano Magro, Davide Baratella, Andrea Venerando, Giulia Nalotto, Caroline R. Basso, Simone Molinari, Gabriella Salviulo, Juri Ugolotti, Valber A. Pedrosa and Fabio Vianello
Materials 2020, 13(7), 1776; https://doi.org/10.3390/ma13071776 - 10 Apr 2020
Cited by 7 | Viewed by 2501
Abstract
Generally, enzyme immobilization on nanoparticles leads to nano-conjugates presenting partially preserved, or even absent, biological properties. Notwithstanding, recent research demonstrated that the coupling to nanomaterials can improve the activity of immobilized enzymes. Herein, xanthine oxidase (XO) was immobilized by self-assembly on peculiar naked [...] Read more.
Generally, enzyme immobilization on nanoparticles leads to nano-conjugates presenting partially preserved, or even absent, biological properties. Notwithstanding, recent research demonstrated that the coupling to nanomaterials can improve the activity of immobilized enzymes. Herein, xanthine oxidase (XO) was immobilized by self-assembly on peculiar naked iron oxide nanoparticles (surface active maghemite nanoparticles, SAMNs). The catalytic activity of the nanostructured conjugate (SAMN@XO) was assessed by optical spectroscopy and compared to the parent enzyme. SAMN@XO revealed improved catalytic features with respect to the parent enzyme and was applied for the electrochemical studies of xanthine. The present example supports the nascent knowledge concerning protein conjugation to nanoparticle as a means for the modulation of biological activity. Full article
(This article belongs to the Special Issue Advanced Functional Nanostructured Biosensors)
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10 pages, 2621 KiB  
Article
Reduced Graphene Oxide-Based Impedimetric Immunosensor for Detection of Enterotoxin A in Milk Samples
by Giovanna S. Rocha, Martin K. L. Silva and Ivana Cesarino
Materials 2020, 13(7), 1751; https://doi.org/10.3390/ma13071751 - 10 Apr 2020
Cited by 13 | Viewed by 2434
Abstract
A simple, cheap, and less aggressive immobilization procedure for biomolecules using reduced graphene oxide (rGO) was employed to prepare an impedimetric immunosensor for detection of staphylococcal enterotoxin A (SEA) from Staphylococcus aureus in milk samples. The scanning electron microscopy, cyclic voltammetry, and electrochemical [...] Read more.
A simple, cheap, and less aggressive immobilization procedure for biomolecules using reduced graphene oxide (rGO) was employed to prepare an impedimetric immunosensor for detection of staphylococcal enterotoxin A (SEA) from Staphylococcus aureus in milk samples. The scanning electron microscopy, cyclic voltammetry, and electrochemical impedance spectroscopy (EIS) were used to monitor the single steps of the electrode assembly process. The glassy carbon (GC)/rGO platform detected the antigen-antibody binding procedures of SEA with concentrations of 0.5 to 3.5 mg L−1 via impedance changes in a low frequency range. The impedimetric immunosensor was successfully applied for the determination of SEA in milk samples. Full article
(This article belongs to the Special Issue Advanced Functional Nanostructured Biosensors)
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12 pages, 3059 KiB  
Article
Using BiVO4/CuO-Based Photoelectrocatalyzer for 4-Nitrophenol Degradation
by Thiago Martimiano do Prado, Fernando Lindo Silva, Guilherme Grosseli, Pedro Sergio Fadini, Orlando Fatibello-Filho and Fernando Cruz de Moraes
Materials 2020, 13(6), 1322; https://doi.org/10.3390/ma13061322 - 14 Mar 2020
Cited by 16 | Viewed by 2864
Abstract
The present work reports the degradation of 4-nitrophenol using BiVO4/CuO hybrid material synthesized by the precipitation of BiVO4 in the presence of CuO. Morphological and structural characterizations were performed using X-ray diffraction and scanning electronic microscopy coupled to energy dispersive [...] Read more.
The present work reports the degradation of 4-nitrophenol using BiVO4/CuO hybrid material synthesized by the precipitation of BiVO4 in the presence of CuO. Morphological and structural characterizations were performed using X-ray diffraction and scanning electronic microscopy coupled to energy dispersive X-ray spectroscopy. Through the calculation of the Kubelka–Munk function applied to diffuse reflectance spectrophotometry data, the hybrid material presented absorption edge of 1.85 eV. The formation of p-n heterojunction between BiVO4 and CuO renders the hybrid material suitable for the construction of a photoanode employed in hydroxyl radical generation. UV–vis spectrophotometry and high-performance liquid chromatography experiments were performed in order to monitor the degradation of 4-nitrophenol and the formation of secondary products. Additional information regarding the hybrid material was obtained through ion chromatography and total organic carbon analyses. The application of BiVO4/CuO-based photocatalyzer led to a 50.2% decrease in total organic carbon after the degradation of 4-nitrophenol. Based on the results obtained in the study, BiVO4/CuO has proved to be a promising material suitable for the removal of recalcitrant compounds in water treatment plants. Full article
(This article belongs to the Special Issue Advanced Functional Nanostructured Biosensors)
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13 pages, 3668 KiB  
Article
A Methodology for Porcine Circovirus 2 (PCV-2) Quantification Based on Gold Nanoparticles
by Caroline R. Basso, Taís F. Cruz, Bruna L. Silva, Valber A. Pedrosa and João P. Araújo Junior
Materials 2020, 13(5), 1087; https://doi.org/10.3390/ma13051087 - 29 Feb 2020
Cited by 8 | Viewed by 2205
Abstract
The aim of the current study is to introduce a methodology aimed at producing a biosensor that uses gold nanoparticles (AuNPs) to detect porcine circovirus 2 (PCV-2). This biosensor was based on AuNPs, which were modified with self-assembled monolayers (SAMs) and antibodies. The [...] Read more.
The aim of the current study is to introduce a methodology aimed at producing a biosensor that uses gold nanoparticles (AuNPs) to detect porcine circovirus 2 (PCV-2). This biosensor was based on AuNPs, which were modified with self-assembled monolayers (SAMs) and antibodies. The AuNPs’ surface and virus modification process applied to enable antibody binding was accompanied by localized surface plasmon resonance (LSPR), surface plasmon resonance (SPR), transmission electron microscopy (TEM), and energy-dispersive X-ray spectroscopy (EDX). Virus quantification was possible by the light absorption difference in the spectrum at concentrations of 105, 106, 107, 108, and 109 DNA copies/mL PCV-2 in relation to quantitative PCR (qPCR), with an R2 value >0.98. The visualization of colorimetric changes in the different PCV-2 concentrations was possible without the use of equipment. The biosensor production methodology presented reproducibility and specificity, as well as easy synthesis and low cost. An enhanced version of it may be used in the future to replace traditional tests such as PCR. Full article
(This article belongs to the Special Issue Advanced Functional Nanostructured Biosensors)
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13 pages, 3694 KiB  
Article
Anti-EGFR-Coated Gold Nanoparticles In Vitro Carry 5-Fluorouracil to Colorectal Cancer Cells
by Raquel B. Liszbinski, Graziela G. Romagnoli, Carolina M. Gorgulho, Caroline R. Basso, Valber A. Pedrosa and Ramon Kaneno
Materials 2020, 13(2), 375; https://doi.org/10.3390/ma13020375 - 14 Jan 2020
Cited by 36 | Viewed by 2987
Abstract
The aim of the current study is to present a strategy to improve the efficiency of 5-fluorouracil (5-FU), which is widely used as antineoplastic agent against solid tumors-based on the use of gold nanocarriers to overcome the resistance of colorectal cancer cells. 5-FU [...] Read more.
The aim of the current study is to present a strategy to improve the efficiency of 5-fluorouracil (5-FU), which is widely used as antineoplastic agent against solid tumors-based on the use of gold nanocarriers to overcome the resistance of colorectal cancer cells. 5-FU was loaded on gold nanoparticles (AuNP) coated with anti-EGFR antibodies in order to target them towards colorectal cancer cells that overexpress epidermal growth factor receptors (EGFR). Physicochemical characterization has shown that AuNP size was approximately 20 nm and that AuNP functionalization led to spherical nanoparticles. Flow cytometry allowed observing that some compounds synthesized by our research group have induced apoptosis/necrosis and impaired the proliferation of colon cancer cell lines ‘HCT-116′ and ‘HT-29′. The antibody/drug combination in AuNP (AuNP 5FU EGFR) has improved the apoptosis rate and impaired cell proliferation in both cell lines, regardless of the exposure time. Overall, these results have shown that AuNP functionalization with monoclonal antibodies focused on delivering 5-FU to tumor cells is an exciting strategy against colorectal cancer. Full article
(This article belongs to the Special Issue Advanced Functional Nanostructured Biosensors)
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