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Organic Nanofibers: Fabrication, Properties and Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Materials Characterization".

Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 6695

Special Issue Editor


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Guest Editor
Department of Engineering and Geology, University of Pescara, Pescara, Italy
Interests: nanoscale self-organization phenomena, including surface effects and solute–solvent interactions and their applications; chemistry and physical chemistry of organic conjugated (semiconductive) molecules and macromolecules; nanocomposites and nanomaterials in general

Special Issue Information

Dear Colleagues,

The field of organic (both molecular and polymeric) nanofibers is the subject of growing interest from both fundamental and applied science, due to the numerous applications emerging for these materials.

In particular, organic nanofibers are of high interest for tissue engineering and drug delivery thanks to their ubiquity in the biological world. In addition, their peculiar one-dimensional character holds great promise for applications in sensors, as well in the more general electronics and optoelectronic fields, including energy generation and storage. Additionally, water treatments like desalination or sanitization can benefit from the use of these materials, due to their ability to form very thin meshes, even in the form of ion-exchanging fibers.

While nanofibers are currently produced mainly by electrospinning, alternative methods of fabrication for these nano-objects are actively sought by the scientific community. In particular, self-assembly appears to be a very promising approach for obtaining nanofibers, as nature demonstrates every day.

Therefore, we would like to present here a Special Issue of Materials dealing with self-assembly methods for the fabrication of organic nanofibers, with a further focus on the already demonstrated and novel applications of so-obtained materials. Regular papers, short communications, reviews, and general commentaries will be included in the Special Issue, and Materials will be happy to host contributions dealing with the aforementioned topics from the whole scientific community gathering around these themes.

Prof. Alessandro Fraleoni Morgera
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Organic nanofibers
  • Self-assembly
  • Tissue engineering
  • Drug delivery
  • Nanoelectronics
  • Energy storage
  • Nanosensors
  • Water desalination
  • Water sanitization

Published Papers (2 papers)

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Research

14 pages, 39429 KiB  
Article
Directional Growth of cm-Long PLGA Nanofibers by a Simple and Fast Wet-Processing Method
by Erik Betz-Güttner, Martina Righi, Silvestro Micera and Alessandro Fraleoni-Morgera
Materials 2022, 15(2), 687; https://doi.org/10.3390/ma15020687 - 17 Jan 2022
Cited by 1 | Viewed by 1857
Abstract
The development of aligned nanofibers as useful scaffolds for tissue engineering is an actively sought-for research objective. Here, we propose a novel improvement of an existing self-assembly-based nanofabrication technique (ASB-SANS). This improvement, which we termed Directional ASB-SANS, allows one to produce cm2 [...] Read more.
The development of aligned nanofibers as useful scaffolds for tissue engineering is an actively sought-for research objective. Here, we propose a novel improvement of an existing self-assembly-based nanofabrication technique (ASB-SANS). This improvement, which we termed Directional ASB-SANS, allows one to produce cm2-large domains of highly aligned poly(lactic-co-glycolic acid) (PLGA) nanofibers in a rapid, inexpensive, and easy way. The so-grown aligned PLGA nanofibers exhibited remarkable adhesion to different substrates (glass, polyimide, and Si/SiOx), even when immersed in PBS solution and kept at physiological temperature (37 °C) for up to two weeks. Finally, the Directional ASB-SANS technique allowed us to grow PLGA fibers also on highly heterogeneous substrates such as polyimide-based, gold-coated flexible electrodes. These results suggest the viability of Directional ASB-SANS method for realizing biocompatible/bioresorbable, nanostructured coatings, potentially suitable for neural interface systems. Full article
(This article belongs to the Special Issue Organic Nanofibers: Fabrication, Properties and Applications)
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15 pages, 2696 KiB  
Article
3D PCL/Gelatin/Genipin Nanofiber Sponge as Scaffold for Regenerative Medicine
by Markus Merk, Orlando Chirikian and Christian Adlhart
Materials 2021, 14(8), 2006; https://doi.org/10.3390/ma14082006 - 16 Apr 2021
Cited by 14 | Viewed by 4247
Abstract
Recent advancements in tissue engineering and material science have radically improved in vitro culturing platforms to more accurately replicate human tissue. However, the transition to clinical relevance has been slow in part due to the lack of biologically compatible/relevant materials. In the present [...] Read more.
Recent advancements in tissue engineering and material science have radically improved in vitro culturing platforms to more accurately replicate human tissue. However, the transition to clinical relevance has been slow in part due to the lack of biologically compatible/relevant materials. In the present study, we marry the commonly used two-dimensional (2D) technique of electrospinning and a self-assembly process to construct easily reproducible, highly porous, three-dimensional (3D) nanofiber scaffolds for various tissue engineering applications. Specimens from biologically relevant polymers polycaprolactone (PCL) and gelatin were chemically cross-linked using the naturally occurring cross-linker genipin. Potential cytotoxic effects of the scaffolds were analyzed by culturing human dermal fibroblasts (HDF) up to 23 days. The 3D PCL/gelatin/genipin scaffolds produced here resemble the complex nanofibrous architecture found in naturally occurring extracellular matrix (ECM) and exhibit physiologically relevant mechanical properties as well as excellent cell cytocompatibility. Samples cross-linked with 0.5% genipin demonstrated the highest metabolic activity and proliferation rates for HDF. Scanning electron microscopy (SEM) images indicated excellent cell adhesion and the characteristic morphological features of fibroblasts in all tested samples. The three-dimensional (3D) PCL/gelatin/genipin scaffolds produced here show great potential for various 3D tissue-engineering applications such as ex vivo cell culturing platforms, wound healing, or tissue replacement. Full article
(This article belongs to the Special Issue Organic Nanofibers: Fabrication, Properties and Applications)
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