Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.4
Journals
Materials
Special Issues
The Effect of Graphene on Cancer
materials-logo
Submit to Materials Review for Materials Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

The Effect of Graphene on Cancer

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 8474

Special Issue Editor

Dr. Mateusz Wierzbicki

E-Mail Website
Guest Editor
Warsaw University of Life Sciences, Warsaw, Poland
Interests: carbon nanomaterials; tumor cells; microenvironment; angiogenesis; cell physiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Graphene, a two-dimensional carbon nanomaterial with unique physicochemical properties, has been widely explored for biomedical applications, including tumor treatment. Wide possibilities of using graphene as a antitumor agent have resulted in the publication of many reports in this area in recent years. However, detailed investigation of graphene biological properties considering its physicochemical structure are needed to improve the understanding of the effect of graphene on cancer.

Graphene anticancer applications are mainly focused on, but not limited to, analysis of direct interaction with tumor cells and development of drug delivery strategies. Graphene and related materials show direct antitumor effects through different mechanisms, including direct plasma membrane damage and mitochondria destabilization. Moreover, versatile capability to conjugate different active compounds to graphene-related materials makes it a promising nanomaterial for different strategies that affect cancer cell physiology, including cell proliferation, migration, and stimulation of angiogenesis. Due to its two-dimensional structure, graphene can serve as a nanoplatform for active compounds like bioactive peptides, drugs, and receptor ligands. Depending on the size of the flakes, graphene can be effectively taken up into cancer cells or strongly adhere to cell surfaces, having high retention at the place of administration, which makes it promising for the limitation of toxicity for healthy tissues.

It is my pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome.

Dr. Mateusz Wierzbicki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • graphene
  • graphene oxide
  • toxicity
  • drug delivery
  • tumor cell physiology
  • graphene interactions
  • biomedical applications

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

22 pages, 7640 KiB  
Article
Effect of Graphene Family Materials on Multiple Myeloma and Non-Hodgkin’s Lymphoma Cell Lines
by Barbara Strojny, Sławomir Jaworski, Irena Misiewicz-Krzemińska, Isabel Isidro, Elizabeta A. Rojas, Norma C. Gutiérrez, Marta Grodzik, Piotr Koczoń, André Chwalibog and Ewa Sawosz
Materials 2020, 13(15), 3420; https://doi.org/10.3390/ma13153420 - 03 Aug 2020
Cited by 3 | Viewed by 2542
Abstract
The interest around the graphene family of materials is constantly growing due to their potential application in biomedical fields. The effect of graphene and its derivatives on cells varies amongst studies depending on the cell and tissue type. Since the toxicity against non-adherent [...] Read more.
The interest around the graphene family of materials is constantly growing due to their potential application in biomedical fields. The effect of graphene and its derivatives on cells varies amongst studies depending on the cell and tissue type. Since the toxicity against non-adherent cell lines has barely been studied, we investigated the effect of graphene and two different graphene oxides against four multiple myeloma cell lines, namely KMS-12-BM, H929, U226, and MM.1S, as well as two non-Hodgkin lymphoma cells lines, namely KARPAS299 and DOHH-2. We performed two types of viability assays, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide conversion) and ATP (adenosine triphosphate detection), flow cytometry analysis of apoptosis induction and cell cycle, cell morphology, and direct interaction analysis using two approaches—visualization of living cells by two different systems, and visualization of fixed and dyed cells. Our results revealed that graphene and graphene oxides exhibit low to moderate cytotoxicity against cells, despite visible interaction between the cells and graphene oxide. This creates possibilities for the application of the selected graphene materials for drug delivery systems or theragnostics in hematological malignancies; however, further detailed studies are necessary to explain the nature of interactions between the cells and the materials. Full article
(This article belongs to the Special Issue The Effect of Graphene on Cancer)
►▼ Show Figures

Figure 1

20 pages, 3948 KiB  
Article
Use of Selected Carbon Nanoparticles as Melittin Carriers for MCF-7 and MDA-MB-231 Human Breast Cancer Cells
by Karolina Daniluk, Marta Kutwin, Marta Grodzik, Mateusz Wierzbicki, Barbara Strojny, Jarosław Szczepaniak, Jaśmina Bałaban, Malwina Sosnowska, Andre Chwalibog, Ewa Sawosz and Sławomir Jaworski
Materials 2020, 13(1), 90; https://doi.org/10.3390/ma13010090 - 23 Dec 2019
Cited by 25 | Viewed by 3290
Abstract
Despite advanced techniques in medicine, breast cancer caused the deaths of 627,000 women in 2018. Melittin, the main component of bee venom, has lytic properties for many types of cells, including cancer cells. To increase its toxic effect, carbon nanoparticles, graphene oxide, pristine [...] Read more.
Despite advanced techniques in medicine, breast cancer caused the deaths of 627,000 women in 2018. Melittin, the main component of bee venom, has lytic properties for many types of cells, including cancer cells. To increase its toxic effect, carbon nanoparticles, graphene oxide, pristine graphene, and diamond were used as carriers of melittin to breast cancer cells. To date, the effects of carbon nanoparticles as carriers of melittin on cancer cells have not been studied. The present study was carried out on MCF-7 and MDA-MB-231 cell lines. The investigation consisted of structural analysis of complexes using transmission electron microscopy, zeta potential measurements, evaluation of cell morphology, assessment of cell viability and membrane integrity, investigation of reactive oxygen species production, and investigation of mitochondrial membrane potential. Cell death was examined by flow cytometry and a membrane test for 43 apoptotic proteins. The results indicate that melittin complex with nanographene oxide has a stronger toxic effect on breast cancer cells than melittin alone. Moreover, nanodiamonds can protect cells against the lytic effects of melittin. All complexes reduced, but not completely eliminated the level of necrosis, compared to melittin. Thus, results suggest that the use of carbon nanoparticles as carriers for melittin may find use in medicine in the future. Full article
(This article belongs to the Special Issue The Effect of Graphene on Cancer)
►▼ Show Figures

Figure 1

14 pages, 1195 KiB  
Article
Influence of Selected Carbon Nanostructures on the CYP2C9 Enzyme of the P450 Cytochrome
by Justyna Sekretarska, Jarosław Szczepaniak, Malwina Sosnowska, Marta Grodzik, Marta Kutwin, Mateusz Wierzbicki, Sławomir Jaworski, Jaśmina Bałaban, Karolina Daniluk, Ewa Sawosz, André Chwalibog and Barbara Strojny
Materials 2019, 12(24), 4149; https://doi.org/10.3390/ma12244149 - 11 Dec 2019
Cited by 3 | Viewed by 2047
Abstract
Carbon nanostructures have recently gained significant interest from scientists due to their unique physicochemical properties and low toxicity. They can accumulate in the liver, which is the main expression site of cytochrome P450 (CYP450) enzymes. These enzymes play an important role in the [...] Read more.
Carbon nanostructures have recently gained significant interest from scientists due to their unique physicochemical properties and low toxicity. They can accumulate in the liver, which is the main expression site of cytochrome P450 (CYP450) enzymes. These enzymes play an important role in the metabolism of exogenous compounds, such as drugs and xenobiotics. Altered activity or expression of CYP450 enzymes may lead to adverse drug effects and toxicity. The objective of this study was to evaluate the influence of three carbon nanostructures on the activity and expression at the mRNA and protein levels of CYP2C9 isoenzyme from the CYP2C subfamily: Diamond nanoparticles, graphite nanoparticles, and graphene oxide platelets. The experiments were conducted using two in vitro models. A microsome model was used to assess the influence of the three-carbon nanostructures on the activity of the CYP2C9 isoenzyme. The CYP2C9 gene expression at the mRNA and protein levels was determined using a hepatoma-derived cell line HepG2. The experiments have shown that all examined nanostructures inhibit the enzymatic activity of the studied isoenzymes. Moreover, a decrease in the expression at the mRNA and protein levels was also observed. This indicates that despite low toxicity, the nanostructures can alter the enzymatic function of CYP450 enzymes, and the molecular pathways involved in their expression. Full article
(This article belongs to the Special Issue The Effect of Graphene on Cancer)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop