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Marine Drugs
Special Issues
Commemorating the Launch of the Section “Marine Biotechnology Related to...
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Commemorating the Launch of the Section “Marine Biotechnology Related to Drug Discovery or Production”

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1587

Special Issue Editor

Dr. Ipek Kurtboke

E-Mail Website
Guest Editor
School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore, QLD 4558, Australia
Interests: microbial ecology and diversity; microbial systematics; biodiscovery; microbial biotechnology applied; environmental and industrial microbiology; marine microbiology; biological control; actinomycetology; bacteriophages
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A new section of Marine Drugs (ISSN 1660-3397), “Marine Biotechnology Related to Drug Discovery or Production”, has been launched. The section aims to collect papers that report on the application of advanced technologies to marine organisms in terms of drug discovery and production.

We are pleased to announce a Special Issue to commemorate the launch of this section. We invite scientists to submit reviews or original research articles studying bioinformatics, culturing techniques, multi-omics, therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes), nanobiotechnology, etc., to further the knowledge regarding marine drug discovery and development.

Kind regards,

Dr. Ipek Kurtboke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cultivation
  • bioinformatics
  • sequencing
  • bioconversion
  • enzymes
  • fermentation
  • omics
  • process technologies
  • marine biodiscovery
  • marine microorganisms
  • marine biotechnology

Published Papers (1 paper)

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Research

16 pages, 17017 KiB  
Article
Novel Approach for Obtaining Variable Domain of New Antigen Receptor with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica)
by Tomofumi Nakada-Masuta, Hiroyuki Takeda and Kazuhisa Uchida
Mar. Drugs 2023, 21(11), 550; https://doi.org/10.3390/md21110550 - 24 Oct 2023
Viewed by 1271
Abstract
Diverse candidate antibodies are needed to successfully identify therapeutic and diagnostic applications. The variable domain of IgNAR (VNAR), a shark single-domain antibody, has attracted attention owing to its favorable physicochemical properties. The phage display method used to screen for optimal VNARs loses sequence [...] Read more.
Diverse candidate antibodies are needed to successfully identify therapeutic and diagnostic applications. The variable domain of IgNAR (VNAR), a shark single-domain antibody, has attracted attention owing to its favorable physicochemical properties. The phage display method used to screen for optimal VNARs loses sequence diversity because of the bias caused by the differential ease of protein expression in Escherichia coli. Here, we investigated a VNAR selection method that combined panning with various selection pressures and next-generation sequencing (NGS) analyses to obtain additional candidates. Drawing inspiration from the physiological conditions of sharks and the physicochemical properties of VNARs, we examined the effects of NaCl and urea concentrations, low temperature, and preheating at the binding step of panning. VNAR phage libraries generated from Japanese topeshark (Hemitriakis japanica) were enriched under these conditions. We then performed NGS analysis and attempted to select clones that were specifically enriched under each panning condition. The identified VNARs exhibited higher reactivity than those obtained by panning without selection pressure. Additionally, they possess physicochemical properties that reflect their respective selection pressures. These results can greatly enhance our understanding of VNAR properties and offer guidance for the screening of high-quality VNAR clones that are present at low frequencies. Full article
(This article belongs to the Special Issue Commemorating the Launch of the Section “Marine Biotechnology Related to Drug Discovery or Production”)
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