Diversity of Marine Fungi as a Source of Bioactive Natural Products, 2nd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1523

Special Issue Editor


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Guest Editor
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Interests: marine natural products; drug discovery; biosynthesis; medicinal chemistry
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Special Issue Information

Dear Colleagues,

Following the success of this Special Issue, titled “Diversity of Marine Fungi as a Source of Bioactive Natural Products” (https://www.mdpi.com/journal/marinedrugs/special_issues/6B6Z19CQ23), we are delighted to announce the second edition on this publication.

Bioactive metabolites sourced from marine-derived fungi are known to be an important source used in drug discovery. Natural product scientists have explored various environments, such as deep oceans, polar regions, and marine mangrove ecosystems, to discover unique fungi strains that have the ability to produce new bioactive structures.

The aim of this Special Issue is to highlight the diversity of fungi derived from different marine environments, as well as their potential as producers of bioactive marine natural products. Innovative scientific results, as well as related approaches and methodologies applied in marine natural product discovery areas, are encouraged. Studies of the biosynthesis and bioactivities of marine natural products are also welcome.

For the second edition of our Special Issue, we invite academic and industry experts to submit reviews and original research articles highlighting the use of diversified marine fungi as a source of bioactive natural products.

Prof. Dr. Dehai Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine fungus
  • bioactivity
  • natural products
  • biosynthesis
  • cytotoxicity
  • antimicrobial activity
  • deep sea

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Published Papers (1 paper)

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Research

14 pages, 3063 KiB  
Article
An Investigation of Quorum Sensing Inhibitors against Bacillus cereus in The Endophytic Fungus Pithomyces sacchari of the Laurencia sp.
by Shi-Liang Xiang, Kai-Zhong Xu, Lu-Jun Yin and Ai-Qun Jia
Mar. Drugs 2024, 22(4), 161; https://doi.org/10.3390/md22040161 - 31 Mar 2024
Viewed by 1323
Abstract
Bacillus cereus, a common food-borne pathogen, forms biofilms and generates virulence factors through a quorum sensing (QS) mechanism. In this study, six compounds (dankasterone A, demethylincisterol A3, zinnimidine, cyclo-(L-Val-L-Pro), cyclo-(L-Ile-L-Pro), and cyclo-(L-Leu-L-Pro)) were isolated from the endophytic fungus Pithomyces sacchari [...] Read more.
Bacillus cereus, a common food-borne pathogen, forms biofilms and generates virulence factors through a quorum sensing (QS) mechanism. In this study, six compounds (dankasterone A, demethylincisterol A3, zinnimidine, cyclo-(L-Val-L-Pro), cyclo-(L-Ile-L-Pro), and cyclo-(L-Leu-L-Pro)) were isolated from the endophytic fungus Pithomyces sacchari of the Laurencia sp. in the South China Sea. Among them, demethylincisterol A3, a sterol derivative, exhibited strong QS inhibitory activity against B. cereus. The QS inhibitory activity of demethylincisterol A3 was evaluated through experiments. The minimum inhibitory concentration (MIC) of demethylincisterol A3 against B. cereus was 6.25 μg/mL. At sub-MIC concentrations, it significantly decreased biofilm formation, hindered mobility, and diminished the production of protease and hemolysin activity. Moreover, RT-qPCR results demonstrated that demethylincisterol A3 markedly inhibited the expression of QS-related genes (plcR and papR) in B. cereus. The exposure to demethylincisterol A3 resulted in the downregulation of genes (comER, tasA, rpoN, sinR, codY, nheA, hblD, and cytK) associated with biofilm formation, mobility, and virulence factors. Hence, demethylincisterol A3 is a potentially effective compound in the pipeline of innovative antimicrobial therapies. Full article
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