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Marine Drugs
Special Issues
Extraction, Characterization and Applications of Marine Polysaccharides
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Extraction, Characterization and Applications of Marine Polysaccharides

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 4184

Special Issue Editors

Dr. Alina Violeta Ursu

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Guest Editor
CNRS, SIGMA Clermont, Institute Pascal, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France
Interests: physicochemical; rheological properties and application of marine biopolymers; polysaccharide; proteins; bioprocesses; seaweed biorefinery
Prof. Dr. Philippe Michaud

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Guest Editor
Institut Pascal, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France
Interests: biochemistry; carbohydrate-acting enzymes; proteins; polysaccharides; bioprocesses; biosourced materials; biorefinery; biotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Olga Babich

E-Mail Website
Guest Editor
Institute of Living Systems, Immanuel Kant Baltic Federal University, Kaliningrad, Russia
Interests: microalgae polysaccharide; oxidative stress; antioxidant activity; biotechnology

Special Issue Information

Dear Colleagues,

Marine environments are a large source of natural products. Among them, polysaccharides are remarkable bioactive polymers acting as antioxidants, antitumorals, antivirals, anti-inflammatory, immunomodulants, prebiotics, elicitors and anticoagulants, among others, but also playing a determinant role in numerous biological processes. Thus, academic and industrial research has focused on the isolation, structural characterization and determination of the properties of new polysaccharides from the ocean with the aim of determining the structure–biological function relationship. The identification of original structures from marine bacteria, fungi, microalgae, cyanobacteria, seaweeds, crustaceans or mollusks is a source of innovation for various applications such as pharmaceutics and cosmetics but also in agronomy, biosourced materials or texturing agents. Exploring the marine environment using blue biotechnologies, in combination with the recent progress in the culture of marine microorganisms, is a new way to examine marine polysaccharides. This Special Issue aims to publish research articles and reviews that focus on the identification of new sources of marine polysaccharides, their structural, physicochemical and rheological characterization, the processes used to extract and purify them and their biological properties.

As the Guest Editors of this Special Issue of Marine Drugs, we encourage you submit your recent research on all the aspects of marine polysaccharides.

Dr. Alina Violeta Ursu
Prof. Dr. Philippe Michaud
Dr. Olga Babich
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine polysaccharides
  • applications
  • bioactivity
  • structure-function relationships
  • biopolymers

Published Papers (2 papers)

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Research

30 pages, 7419 KiB  
Article
A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-heparanase and Anti-migratory Activities
by Chanez Manseur, Hugo Groult, Manon Porta, Pierre-Edouard Bodet, Rachida Mersni-Achour, Raphaëlle Petit, Samir Ali-Moussa, Benjamin Musnier, Didier Le Cerf, Tony Varacavoudin, Oualid Haddad, Angela Sutton, Cíntia Emi Yanaguibashi Leal, Edilson Beserra Alencar-Filho, Jean-Marie Piot, Nicolas Bridiau, Thierry Maugard and Ingrid Fruitier-Arnaudin
Mar. Drugs 2023, 21(5), 295; https://doi.org/10.3390/md21050295 - 11 May 2023
Viewed by 1777
Abstract
Oligosaccharides derived from λ-carrageenan (λ-COs) are gaining interest in the cancer field. They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications. However, one [...] Read more.
Oligosaccharides derived from λ-carrageenan (λ-COs) are gaining interest in the cancer field. They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications. However, one of the specific features of commercial λ-carrageenan (λ-CAR) is that they are heterogeneous mixtures of different CAR families, and are named according to the thickening-purpose final-product viscosity which does not reflect the real composition. Consequently, this can limit their use in a clinical applications. To address this issue, six commercial λ-CARs were compared and differences in their physiochemical properties were analyzed and shown. Then, a H2O2-assisted depolymerization was applied to each commercial source, and number- and weight-averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined. By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in terms of molar masses and DS, which ranged within previously reported values suitable for antitumor properties. However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features, such as differences in the initial mixture composition. Further structural MS and NMR analysis revealed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, and it also showed that H2O2-based hydrolysis induced sugar degradation. Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity. Full article
(This article belongs to the Special Issue Extraction, Characterization and Applications of Marine Polysaccharides)
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19 pages, 3360 KiB  
Article
Extraction, Structural Characterization, and In Vivo Anti-Inflammatory Effect of Alginate from Cystoseira crinita (Desf.) Borry Harvested in the Bulgarian Black Sea
by Vesela Kokova, Paolina Lukova, Alexandra Baldzhieva, Plamen Katsarov, Cédric Delattre, Roland Molinié, Emmanuel Petit, Redouan Elboutachfaiti, Marianna Murdjeva and Elisaveta Apostolova
Mar. Drugs 2023, 21(4), 245; https://doi.org/10.3390/md21040245 - 16 Apr 2023
Cited by 3 | Viewed by 1908
Abstract
The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats. The serum levels of TNF-α, IL-1β, [...] Read more.
The aim of this study was to identify the chemical composition and sequential structure of alginate isolated from C. crinita harvested in the Bulgarian Black Sea, as well as its effects in histamine-induced paw inflammation in rats. The serum levels of TNF-α, IL-1β, IL-6, and IL-10 in rats with systemic inflammation, and the levels of TNF-α in a model of acute peritonitis in rats were also investigated. The structural characterization of the polysaccharide was obtained by FTIR, SEC-MALS, and 1H NMR. The extracted alginate had an M/G ratio of 1.018, a molecular weight of 7.31 × 104 g/mol, and a polydispersity index of 1.38. C. crinita alginate in doses of 25 and 100 mg/kg showed well-defined anti-inflammatory activity in the model of paw edema. A significant decrease in serum levels of IL-1β was observed only in animals treated with C. crinita alginate in a dose of 25 mg/kg bw. The concentrations of TNF-α and IL-6 in serum were significantly reduced in rats treated with both doses of the polysaccharide, but no statistical significance was observed in the levels of the anti-inflammatory cytokine IL-10. A single dose of alginate did not significantly alter the levels of the pro-inflammatory cytokine TNF-α in the peritoneal fluid of rats with a model of peritonitis. Full article
(This article belongs to the Special Issue Extraction, Characterization and Applications of Marine Polysaccharides)
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