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Biomolecules
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Biomolecules from Alga: Biological Effect and Pharmacological Properties Volume 2
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Biomolecules from Alga: Biological Effect and Pharmacological Properties Volume 2

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-inspired Molecules".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 7638

Special Issue Editor

Prof. Dr. Philippe Michaud

E-Mail Website
Guest Editor
Institut Pascal, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France
Interests: biochemistry; carbohydrate-acting enzymes; proteins; polysaccharides; bioprocesses; biosourced materials; biorefinery; biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Algae are mainly composed of proteins, carbohydrates, lipids, and trace nutrients including vitamins, antioxidants, and other elements. These photoautotrophic organisms include eukaryotes (macro- and microalgae) and prokaryotic Cyanobacteria (also called blue-green microalgae) living in various aquatic but also nonaquatic habitats. Algae have the potential to play pivotal roles in remedying the prevailing global energy, environment, and food crisis. Indeed, bioactive compounds from algae such as proteins, fatty acids, carbohydrates, vitamins, and pigments can be sourced directly from their primary or secondary metabolism. Many of these compounds have been described as having antifungal, antiviral, antialgal, antienzymatic, antibiotic, antimicrobial, antioxidant, and anti-inflammatory capacities, with great potential for the development of new products for medical, pharmaceutical, cosmetic, and food industries. This Special Issue encompasses the roles of alga in biomolecule production, including screening of extracts or isolation of new metabolites and assessment of their biological activity.

Prof. Dr. Philippe Michaud
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • seaweed
  • microalgae
  • cyanobacteria
  • blue biotechnology
  • algae
  • bioactive compounds

Related Special Issue

Published Papers (4 papers)

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Research

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16 pages, 4910 KiB  
Article
Seasonal Changes in the Biochemical Constituents of Green Seaweed Chaetomorpha antennina from Covelong, India
by A. Vinuganesh, Amit Kumar, Shereen Magdy Korany, Emad A. Alsherif, Samy Selim, Sanjeevi Prakash, Gerrit T. S. Beemster and Hamada AbdElgawad
Biomolecules 2022, 12(10), 1475; https://doi.org/10.3390/biom12101475 - 13 Oct 2022
Cited by 6 | Viewed by 1740
Abstract
Seaweeds are well known for having a wealth of nutritional benefits and providing ecological support to associated fauna. Seasonality influences the biochemical characteristics, affecting their ecological and economic values. In the present study, we evaluated pigments, primary and secondary metabolites, minerals, and antioxidant [...] Read more.
Seaweeds are well known for having a wealth of nutritional benefits and providing ecological support to associated fauna. Seasonality influences the biochemical characteristics, affecting their ecological and economic values. In the present study, we evaluated pigments, primary and secondary metabolites, minerals, and antioxidant properties of green seaweed Chaetomorpha antennina growing on the intertidal rocks along the Covelong coast, India, in different seasons (from June 2019 to March 2020). Significant variations were found in the levels of antioxidants, minerals, and metabolites in different seasons, e.g., amino acid levels were the highest in post-monsoon and the lowest in summer. In monsoon, we found the highest concentration of fatty acids in the thalli. Lipid peroxidation and total antioxidant activity were at their maximum levels during post-monsoon, which indicated oxidative damage responses. No significant variations were found in the levels of photosynthetic pigments. The outcomes indeed suggested seasonal variations in the biochemical and nutrient profile of C. antennina. We suggest that the harvesting/collection of C. antennina for different nutrients and metabolites should be performed in the respective seasons. Full article
(This article belongs to the Special Issue Biomolecules from Alga: Biological Effect and Pharmacological Properties Volume 2)
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14 pages, 2055 KiB  
Article
Improvement of Biomass and Phycoerythrin Production by a Strain of Rhodomonas sp. Isolated from the Tunisian Coast of Sidi Mansour
by Hana Derbel, Jihen Elleuch, Latifa Tounsi, Marco Sebastiano Nicolo, Maria Giovanna Rizzo, Philippe Michaud, Imen Fendri and Slim Abdelkafi
Biomolecules 2022, 12(7), 885; https://doi.org/10.3390/biom12070885 - 24 Jun 2022
Cited by 8 | Viewed by 1731
Abstract
Microalgae are photoautotrophic microorganisms known as producers of a large variety of metabolites. The taxonomic diversity of these microorganisms has been poorly explored. In this study, a newly isolated strain was identified based on the 18S rRNA encoding gene. The phylogenetic analysis showed [...] Read more.
Microalgae are photoautotrophic microorganisms known as producers of a large variety of metabolites. The taxonomic diversity of these microorganisms has been poorly explored. In this study, a newly isolated strain was identified based on the 18S rRNA encoding gene. The phylogenetic analysis showed that the isolated strain was affiliated with the Rhodomonas genus. This genus has greatly attracted scientific attention according to its capacity to produce a large variety of metabolites, including phycoerythrin. Growth and phycoerythrin production conditions were optimized using a Plackett–Burman design and response surface methodology. An expression profile analysis of the cpeB gene, encoding the beta subunit of phycoerythrin, was performed by qRT-PCR under standard and optimized culture conditions. The optimization process showed that maximum cell abundance was achieved under the following conditions: CaCl2 = 2.1328 g/L, metal solution = 1 mL/L, pH = 7 and light intensity = 145 μmol photons/m2/s, whereas maximum phycoerythrin production level occurred when CaCl2 = 1.8467 g/L, metal solution = 1 mL/L, pH = 7 and light intensity = 157 μmol/m2/s. In agreement, positive transcriptional regulation of the cpeB gene was demonstrated using qRT-PCR. This study showed the successful optimization of abiotic conditions for highest growth and phycoerythrin production, making Rhodomonas sp. suitable for several biotechnological applications. Full article
(This article belongs to the Special Issue Biomolecules from Alga: Biological Effect and Pharmacological Properties Volume 2)
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11 pages, 1412 KiB  
Article
Influence of Carbon Sources on the Phenolic Compound Production by Euglena gracilis Using an Untargeted Metabolomic Approach
by Eve Bernard and Céline Guéguen
Biomolecules 2022, 12(6), 795; https://doi.org/10.3390/biom12060795 - 07 Jun 2022
Cited by 3 | Viewed by 1687
Abstract
Industrial development and urbanization has led to the diverse presence of metals in wastewater that are often improperly treated. The microalgae Euglena gracilis can tolerate high concentrations of metal via the excretion of organic metabolites, including phenolics. This study aims to evaluate how [...] Read more.
Industrial development and urbanization has led to the diverse presence of metals in wastewater that are often improperly treated. The microalgae Euglena gracilis can tolerate high concentrations of metal via the excretion of organic metabolites, including phenolics. This study aims to evaluate how carbon amendment stimulates phenolic compound production by E. gracilis. The number, relative intensity and molecular composition of the phenolic compounds were significantly different between each of four carbon amended cultures (i.e., glutamic acid, malic acid, glucose, reduced glutathione) during the log phase. Phenolic compounds were mainly produced during the minimum growth rate, likely a response to stressful conditions. A better understanding of phenolic compounds production by E. gracilis and the impact of growth conditions will help identify conditions that favor certain phenolic compounds for dietary and metal chelation applications. Full article
(This article belongs to the Special Issue Biomolecules from Alga: Biological Effect and Pharmacological Properties Volume 2)
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Review

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34 pages, 1853 KiB  
Review
Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?
by Vitória Ramos, Mariana Reis, Leonor Ferreira, Ana Margarida Silva, Ricardo Ferraz, Mónica Vieira, Vitor Vasconcelos and Rosário Martins
Biomolecules 2023, 13(10), 1444; https://doi.org/10.3390/biom13101444 - 25 Sep 2023
Cited by 1 | Viewed by 1820
Abstract
Neurodegenerative diseases (NDs) are characterized by progressive and irreversible neuronal loss, accompanied by a range of pathological pathways, including aberrant protein aggregation, altered energy metabolism, excitotoxicity, inflammation, and oxidative stress. Some of the most common NDs include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), [...] Read more.
Neurodegenerative diseases (NDs) are characterized by progressive and irreversible neuronal loss, accompanied by a range of pathological pathways, including aberrant protein aggregation, altered energy metabolism, excitotoxicity, inflammation, and oxidative stress. Some of the most common NDs include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and Huntington’s Disease (HD). There are currently no available cures; there are only therapeutic approaches that ameliorate the progression of symptoms, which makes the search for new drugs and therapeutic targets a constant battle. Cyanobacteria are ancient prokaryotic oxygenic phototrophs whose long evolutionary history has resulted in the production of a plethora of biomedically relevant compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, that can be valuable in this field. This review summarizes the major NDs and their pathophysiology, with a focus on the anti-neurodegenerative properties of cyanobacterial compounds and their main effects. Full article
(This article belongs to the Special Issue Biomolecules from Alga: Biological Effect and Pharmacological Properties Volume 2)
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