Marine Streptomyces-Derived Natural Products 2024

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1707

Special Issue Editors


E-Mail Website
Guest Editor
Department of Chemistry and Nano Science, College of Natural Sciences Ewha Womans University, Seodaemun-gu, Seoul 120-750, Republic of Korea
Interests: marine natural prodcuts; structure elucidation of natural products; antibacteiral and anti-cancer natural products
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
Interests: marine actinomycetes; natural products; NMR; structure elucidation; antibiotics; symbiosis; biosynthesis; genomics
Special Issues, Collections and Topics in MDPI journals
Ocean Science & Technology School, Korea Maritime and Ocean University, Busan 49112, Republic of Korea
Interests: bioactivity natural product; chemistry; chromatography; medicinal and pharmaceutical chemistry; phytochemicals; extraction; antimicrobials; antioxidant activity

Special Issue Information

Dear Colleagues,

It is widely acknowledged that marine microorganisms possess considerable potential as sources of bioactive natural products. Streptomyces, a principal subdivision of Actinobacteria, has been the subject of extensive investigation for its novel secondary metabolites. This fertile microbial genus accounts for over 80% of actinomycete natural products and approximately 50% of all known antibiotics.

Therefore, Streptomyces strains derived from marine-related environments require attention from researchers. More specifically, the most recent advanced approaches demand a thorough examination, such as an isolation strategy for the bioactive metabolites producing Streptomyces strains, applications of the metabolites based on their wide range of bioactivities, and the chemical structure elucidation of marine microbial secondary metabolites. This Special Issue is dedicated to studying the inherent potential of these microorganisms as an abundant reservoir of marine natural products.

Dr. Sang-Jip Nam
Dr. Dong-Chan Oh
Dr. Inho Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine streptomyces
  • marine natural product
  • chemical structure elucidation
  • bioactive secondary metabolite
  • drug hit/lead discovery

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 4201 KiB  
Article
Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells
by Sultan Pulat, Inho Yang, Jihye Lee, Sunghoon Hwang, Rui Zhou, Chathurika D. B. Gamage, Mücahit Varlı, İsa Taş, Yi Yang, So-Yeon Park, Ahreum Hong, Jeong-Hyeon Kim, Dong-Chan Oh, Hangun Kim, Sang-Jip Nam and Heonjoong Kang
Mar. Drugs 2024, 22(2), 88; https://doi.org/10.3390/md22020088 - 14 Feb 2024
Viewed by 1532
Abstract
Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined [...] Read more.
Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells. Full article
(This article belongs to the Special Issue Marine Streptomyces-Derived Natural Products 2024)
Show Figures

Graphical abstract

Back to TopTop