Model Organisms in DNA Damage Repair

Dear Colleagues,

Aim:

The primary aim of this Special Issue is to deliver a comprehensive and in-depth exploration of the pivotal role that model organisms play in advancing our understanding of DNA damage repair mechanisms. This Special Issue aspires to underscore the profound significance of model organisms as indispensable tools for dissecting the intricacies of DNA repair pathways, ranging from prokaryotes to complex multicellular organisms.

Scope:

This Special Issue will encompass an array of key areas, including the following:

Diverse model organisms: We will cast a spotlight on a diverse array of model organisms, spanning bacteria (e.g., Escherichia coli), yeast (e.g., Saccharomyces cerevisiae), nematodes (e.g., Caenorhabditis elegans), insects (e.g., Drosophila melanogaster), and mammals (e.g., Mus musculus). By showcasing the contributions of these organisms, we will illustrate how each has played a unique role in advancing DNA damage repair research.

In-depth DNA damage repair pathways: The Special Issue will offer comprehensive insights into various DNA repair pathways, including base excision repair, nucleotide excision repair, homologous recombination, non-homologous end joining, and mismatch repair. It will elucidate how model organisms have not only shed light on these processes but also unearthed conserved and distinctive repair mechanisms.

Comparative studies: We will delve into compelling comparative studies, highlighting how the utilization of different model organisms has enriched our comprehension of DNA damage repair. These studies will illuminate how insights from diverse species have deepened our understanding of DNA repair pathways.

Cutting-edge technologies: Discussions will encompass state-of-the-art technologies and tools, including revolutionary genome editing techniques (e.g., CRISPR-Cas9) and advanced imaging methods. We will explore how these innovations have transformed DNA damage repair research using model organisms.

Clinical implications: The Special Issue will not only delve into the scientific aspects but also emphasize the clinical and translational implications of DNA damage repair research. It will explore potential therapeutic targets and strategies to combat human diseases linked to DNA damage, particularly cancer.

Anticipated research trajectories: The scope extends to providing insights into the future directions of DNA damage repair research with model organisms. This includes the emergence of new model systems and interdisciplinary approaches that promise to push the boundaries of our knowledge in this field.

In essence, this Special Issue endeavors to offer a comprehensive and insightful overview of the invaluable contributions made by model organisms in unraveling the intricate mechanisms of DNA damage repair. It is poised to be an indispensable resource for researchers, educators, and individuals with a keen interest in the converging domains of genetics, molecular biology, and genomic stability.

Dr. Hyun-Min Kim
Prof. Dr. Da-Tian Bau
Guest Editors

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