Mitochondrial Function and Signaling to Regulate Cellular Life: 2nd Edition
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".
Deadline for manuscript submissions: 15 May 2024 | Viewed by 110
Special Issue Editor
Interests: mitochondria; oxidative stress; exercise physiology; skeletal muscle
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The primary role of the mitochondria is to supply ATP to the cell; however, these organelles are also signaling hubs which receive and transmit signals to most cellular compartments. The importance of mitochondria in living cells is characterized by the fact that severe mitochondrial stress can result in cellular apoptosis. Therefore, mitochondria have evolved to adapt in order to properly maintain cellular function under stressful environments. In this regards, mitochondria undergoes a cell-like cycle where dysfunctional parts are separated through fission in order to be removed by the lysosome. Additionally, mitochondria are constantly synthesized (biogenesis) in a mechanism coordinated by both the nuclear and the mitochondrial genomes, which constantly engage in crosstalk. Moreover, mitochondria can also manage stress by changing their shape in conditions such as exercise or starvation, with the ultimate goal to accommodate the energetic demands of the cell. Therefore, understanding the mitochondrial response to stress and the molecular mechanisms that enhance mitochondrial function will be of great value to prevent and reverse a variety of age-related metabolic diseases.
Dr. Rafael A. Casuso
Guest Editor
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Keywords
- mitochondrial function
- exercise
- nutrition
- reactive oxygen species
- electron transport chain
- metabolic disease
Related Special Issue
- Mitochondrial Function and Signaling to Regulate Cellular Life in Life (11 articles)
