Pathogenic Mechanisms, Diagnosis, and Treatment of Hypertension: Insights and Implications

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 192

Special Issue Editors

E-Mail Website
Guest Editor
Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Interests: Blood pressure disorder; Hypertension

E-Mail Website
Guest Editor
Nutrition and Food Sciences Program, Department of Human Sciences, University of Arkansas at Pine Bluff, Pine Bluff, AK, USA
Interests: diet and nutrition in the prevention of chronic diseases

Special Issue Information

Dear Colleagues

More than one billion people worldwide suffer from hypertension, a leading cause of cardiovascular disease and the primary risk factor for cardiovascular mortality. In the U.S., approximately 670,000 deaths yearly are attributed to hypertension as a primary or contributing cause. Unfortunately, achieving adequate blood pressure control poses a significant challenge, with only around 25% of hypertensive patients in the U.S. attaining normal blood pressure levels through medication regimens. Moreover, discontinuing antihypertensive medications is not an option, even for patients with controlled blood pressure, as sustained elevation tends to recur. These alarming statistics underscore the critical need to identify unknown mechanisms involved in hypertension’s pathogenesis and design improved medications for its treatment. The pathogenesis of hypertension involves an intricate interplay among various systemic regulations within the body, including the renin–angiotensin–aldosterone system (RAAS), vasculature system, renal sodium-fluid regulation system, sympathetic nervous system, metabolic regulation system, immune system, genetic factors, lifestyle factors, and more. This multidimensional perspective highlights the urgency for comprehensive research aimed at unraveling the complexities of hypertension’s mechanisms. Efforts in this direction are essential for the development of advanced diagnostic tools and therapeutic interventions that can effectively address this widespread health challenge. In light of these imperative research needs, we cordially invite the submission of research and review papers contributing to our understanding of hypertension’s pathogenesis and proposing innovative solutions for its diagnosis and treatment. Researchers and experts in the field are encouraged to share their findings and insights, fostering a collaborative effort to advance our capabilities in combating this global health crisis.

Dr. Shengyu Mu
Dr. Sankar Devarajan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • hypertension
  • cardiovascular disease
  • blood pressure
  • pathogenesis

Published Papers

This special issue is now open for submission.
Back to TopTop