Cancer Cell Reprogramming and Emerging Approaches

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".

Deadline for manuscript submissions: closed (22 April 2024) | Viewed by 154

Special Issue Editors


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Guest Editor
National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA
Interests: neurological disorders; cancer metabolism; genetics; heredity toxicology biochemistry; molecular biology cell biology

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Guest Editor
School of Medicine, Indiana University, Bloomington, IN 47405, USA
Interests: basic mechanism of alcohol-induced liver injury; neutrophils in ALD pathogenesis

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Guest Editor
Department of Medicine-Oncology & Hematology, Columbia University Irving Medical Center, New York, NY, USA
Interests: leukemia; cytokines; radiation oncology

Special Issue Information

Dear Colleagues,

Since the concept of cellular plasticity was established, remarkable progress has been made in reprogramming terminally differentiated somatic cells and cancer cells into induced pluripotent cells and cancer cells with benign phenotypes. Cancer cell reprogramming has emerged as a promising strategy which can induce the transition from malignancy to benignity. A number of intra- and extracellular factors are already described to be implicated in cancer cell reprogramming, such as epigenetic factors, genetic mutations, intracellular pro-malignant, and pro-survival signaling pathways, etc. Additionally, a variety of microenvironmental factors play a critical role in the formation of carcinoma cells of different aggressiveness and sensitivities to currently used therapeutic approaches. Thus, it is proposed that hypoxia and non-malignant cells comprising the tumor such as stroma cells and immune cells could also modify the physiological and molecular properties of carcinoma cells and affect their sensitivities to treatment.

In the past decade, increasing studies have explored various approaches to induce reprogramming from one cell type to another, including lineage-specific transcription factors-, combinatorial small molecules-, microRNAs-, metabolism- and embryonic microenvironment-derived exosome-mediated reprogramming. Much effort has been focused on optimizing reprogramming protocols and deciphering molecular mechanisms to achieve high efficiency, safety, and specificity. The rapid evolution of cancer cell reprogramming has provided substantial insights into biomedical science and translational medicine.

The aim of this Special Issue is to highlight the variety of factors associated with cancer cell reprogramming and the recent approaches to facilitating reprogramming therapy for in vitro/in vivo cancer transition.

Dr. Yan Ma
Dr. Jing Ma
Dr. Sanjay Mukherjee
Guest Editors

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Published Papers

There is no accepted submissions to this special issue at this moment.
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