Dear Colleagues,

Pulmonary fibrosis (PF) is a progressive chronic interstitial lung disease characterized by robust remodeling and scarring of the lung resulting in stiffening of lung vasculature and causes other pathological changes that compromises the lung function. PF is caused by several factors including inflammation, smoke and gene mutation. PF also manifests as secondary to other lung diseases including pulmonary hypertension and are caused due to other unknown etiologies that are collectively defined as idiopathic pulmonary fibrosis (IPF), a major type of PF. Despite ongoing efforts to identify a cure, currently, there is no medication for PF and treatment options largely relies on impeding lung scarring with drugs and steroids and lung transplantation being the last resort in severe cases of PF with limited success. The global incidence of PF increases every year with a higher rate of morbidity and mortality worldwide. Therefore, there is an urgent need to understand the pathophysiology and molecular mechanisms underlying this complex disease of PF and to identify a novel and effective treatment strategies to improve the quality of life of PF patient community.

This Special Issue aims to provide our readers with the current knowledge and understanding and novel therapeutic approaches for the treatment of PF. We welcome original research articles, reviews, meta-analyses/systematic reviews, or shorter perspective articles, as well novel technological approaches on all aspects related to the pathophysiological, molecular aspects and treatment options of pulmonary fibrosis, caused by inflammation, genetic aberration and other idiopathic etiologies including pulmonary hypertension.

Dr. Arun Samidurai
Guest Editor

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• pulmonary fibrosis
• pulmonary arterial hypertension
• myocardial infarction
• epigenetics