Functional Scaffolds for Bone and Joint Surgery

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 1391

Special Issue Editors


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Guest Editor
Department of Constructional Materials and Biomaterials Materials and Biomaterials, Faculty of Materials Engineering, Kazimierz Wielki University, Bydgoszcz, Poland
Interests: bone tissue biomechanics and endocrinology; orthopaedic biomaterials; connecting scaffolds for resurfacing arthroplasty endoprostheses; surface modification and functionalization of biomaterials
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E-Mail Website
Guest Editor
Department of Constructional Materials and Biomaterials, Faculty of Materials Engineering, Kazimierz Wielki University, Bydgoszcz, Poland
Interests: orthopaedic biomaterials; engineering of bone–implant interface; scaffolds for bone reconstruction; surface modification and functionalization of biomaterials
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Adult Spine Orthopaedics Department, Poznan University of Medical Sciences, Poznan, Poland
Interests: morphological changes in the course of degenerative spine disease biomechanical evaluation of spine and hip implants; concentration of metals and elements in the motion system; quality of life in elderly patients with spine diseases; back pain syndromes especially in degenerative disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

One of the ultimate goals of bone and joint surgery is reconstruction via the implantation of a device to replace the bone and/or joints affected by disease or traumatic damage or deformity. In the case of reconstruction of large osseous defects, which remains a significant challenge, 3D scaffolds are developed architectures that promote native tissue regeneration and are used as a template for bone tissue engineering. The recent progress in the field of biomaterials science and engineering, and in modern manufacturing approaches in addition to design strategy allow for tackling this challenge by creating functionally graded scaffolds mimicking the anatomical geometry of bone with varied pore size distribution and gradual structural and mechanical properties of the different morphological structures of a given joint that facilitates bearing external loading. Apart from structurally functional (osteoconductive) designs, continuing efforts are held to develop osteoinductive scaffolds offering enhanced performance for interactions with host tissues. Such functional (or multifunctional) scaffolds are seeded with mesenchymal stromal cells and involve biomolecules and growth factors producing biological signals to stimulate the proliferation and differentiation of bone marrow mesenchymal stem cells and osteoblast-like cells to promote bone regeneration. They are simultaneously capable of inhibiting local bacterial infections (intrinsically antimicrobial or loaded with antibiotics, peptides, antimicrobial metallic ions and/or nanoparticles) or, e.g., addressing bone cancer therapies (preventing the recurrence of the tumor) involving hyperthermia, photothermal and/or localized drug delivery.

This Special Issue aims to exhibit and discuss the latest advancements in functional scaffolds for bone and joint surgery. It is our pleasure to invite you to submit a manuscript to this Special Issue. Full papers, communications and reviews are welcome.

Potential topics include, but are not limited to, the following:

  • Methods for functionalizing scaffolds to support a variety of in vivo functions;
  • Development of functional 3D scaffolds within tissue engineering;
  • Novel biomaterials and biofactors for functional scaffolds;
  • Conventional and advanced technologies for functional 3D scaffold engineering;
  • Applications of functional scaffolds in surgical treatment procedures.

Prof. Dr. Ryszard Uklejewski
Dr. Mariusz Winiecki
Dr. Mikołaj Dąbrowski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional scaffolds
  • osteoconductive scaffolds
  • osteoinductive scaffolds
  • porous scaffolds
  • bone scaffolding
  • 3D-printed scaffolds
  • drug delivery scaffolds
  • bone regeneration
  • bone and joint surgery

Published Papers (1 paper)

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Research

19 pages, 4533 KiB  
Article
Characterization and In Vitro Evaluation of Porous Polymer-Blended Scaffolds Functionalized with Tricalcium Phosphate
by Iwona Pudełko-Prażuch, Mareeswari Balasubramanian, Sundara Moorthi Ganesan, Stanisław Marecik, Kamila Walczak, Kinga Pielichowska, Suvro Chatterjee, Ravichandran Kandaswamy and Elżbieta Pamuła
J. Funct. Biomater. 2024, 15(3), 57; https://doi.org/10.3390/jfb15030057 - 26 Feb 2024
Viewed by 1037
Abstract
Bone tissue is one of the most transplanted tissues. The ageing population and bone diseases are the main causes of the growing need for novel treatments offered by bone tissue engineering. Three-dimensional (3D) scaffolds, as artificial structures that fulfil certain characteristics, can be [...] Read more.
Bone tissue is one of the most transplanted tissues. The ageing population and bone diseases are the main causes of the growing need for novel treatments offered by bone tissue engineering. Three-dimensional (3D) scaffolds, as artificial structures that fulfil certain characteristics, can be used as a temporary matrix for bone regeneration. In this study, we aimed to fabricate 3D porous polymer scaffolds functionalized with tricalcium phosphate (TCP) particles for applications in bone tissue regeneration. Different combinations of poly(lactic acid) (PLA), poly(ethylene glycol) (PEG with molecular weight of 600 or 2000 Da) and poly(ε-caprolactone) (PCL) with TCP were blended by a gel-casting method combined with rapid heating. Porous composite scaffolds with pore sizes from 100 to 1500 µm were obtained. ATR-FTIR, DSC, and wettability tests were performed to study scaffold composition, thermal properties, and hydrophilicity, respectively. The samples were observed with the use of optical and scanning electron microscopes. The addition of PCL to PLA increased the hydrophobicity of the composite scaffolds and reduced their susceptibility to degradation, whereas the addition of PEG increased the hydrophilicity and degradation rates but concomitantly resulted in enhanced creation of rounded mineral deposits. The scaffolds were not cytotoxic according to an indirect test in L929 fibroblasts, and they supported adhesion and growth of MG-63 cells when cultured in direct contact. Full article
(This article belongs to the Special Issue Functional Scaffolds for Bone and Joint Surgery)
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