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Analysis and Pharmacological Evaluation of New Synthetic and Natural Molecules...
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Analysis and Pharmacological Evaluation of New Synthetic and Natural Molecules in Drug Discovery

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 2916

Special Issue Editors

Dr. Waquar Ahsan

E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry and Pharmacognosy, Jazan University, Jazan, Saudi Arabia
Interests: synthesis; analysis; pharmacological evaluation; natural products; biosensors
Dr. Asim Najmi

E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry and Pharmacognosy, Jazan University, Jazan, Saudi Arabia
Interests: synthesis; analysis; pharmacological evaluation; natural products; anticancer; antidiabetic

Special Issue Information

Dear Colleagues,

The discovery of new drugs for various diseases has always been of much importance owing to many reasons, including development of drug resistance, occurrence of side effects and treatment of untreatable and newly emerging conditions. New drugs are required continuously as the disease-causing vectors are continuing to evolve and become resistant to the existing drugs posing new challenges to human beings. Different sources of lead compounds include computer-aided drug design, synthesis in laboratory and natural products followed by optimization to achieve new molecules as future drug candidates. These new chemical entities have the potential to become therapeutic agents and they might be of value in the treatment of disease conditions with unmet medical needs.

This Special Issue aims to publish research and review articles related to the synthesis of new chemical entities, as well as isolation, purification and characterization of natural bioactive compounds and their pharmacological evaluation against various diseases. We invite high-quality manuscripts for submission to the Special Issue from experts around the globe dealing with drug discovery for various infectious and non-infectious diseases. Topics will include but not limited to synthesis of novel heterocyclic compounds, molecular modeling, screening of natural sources, analytical and bioanalytical method development, etc. The content of this Special Issue will be of great importance and will add value to the knowledge of scientific community involved in the development of new drug molecules for the treatment of diseases.

Dr. Waquar Ahsan
Dr. Asim Najmi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthesis
  • analysis
  • pharmacological evaluation
  • natural products
  • molecular modeling
  • screening
  • activity

Published Papers (1 paper)

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Research

16 pages, 6480 KiB  
Article
Evaluation of Antidiabetic Effect of Luteolin in STZ Induced Diabetic Rats: Molecular Docking, Molecular Dynamics, In Vitro and In Vivo Studies
by Kahksha, Ozair Alam, Lamya Ahmed Al-Keridis, Jalaluddin Khan, Sameena Naaz, Afshar Alam, Syed Amir Ashraf, Nawaf Alshammari, Mohd Adnan and Md Amjad Beg
J. Funct. Biomater. 2023, 14(3), 126; https://doi.org/10.3390/jfb14030126 - 25 Feb 2023
Cited by 7 | Viewed by 2144
Abstract
Despite the existence of modern antidiabetic medications, diabetes still affects millions of individuals worldwide, with a high death and disability rate. There has been a concerted search for alternative natural medicinal agents; luteolin (LUT), a polyphenolic molecule, might be a good choice, both [...] Read more.
Despite the existence of modern antidiabetic medications, diabetes still affects millions of individuals worldwide, with a high death and disability rate. There has been a concerted search for alternative natural medicinal agents; luteolin (LUT), a polyphenolic molecule, might be a good choice, both because of its efficacy and because of it having fewer side effects, compared to conventional medicines. This study aims to explore the antidiabetic potential of LUT in diabetic rats, induced by streptozotocin (STZ; 50 mg/kg b.w.), intraperitoneally. The level of blood glucose, oral glucose tolerance test (OGTT), body weight, glycated hemoglobin A1c (HbA1c), lipidemic status, antioxidant enzymes, and cytokines were assessed. Also, its action mechanism was explored through molecular docking and molecular dynamics simulations. Oral supplementation of LUT for 21 days resulted in a significant decrease in the blood glucose, oxidative stress, and proinflammatory cytokine levels, and modulated the hyperlipidemia profile. LUT also ameliorated the tested biomarkers of liver and kidney function. In addition, LUT markedly reversed the damage to the pancreas, liver, and kidney cells. Moreover, molecular docking and molecular dynamics simulations revealed excellent antidiabetic behavior of LUT. In conclusion, the current investigation revealed that LUT possesses antidiabetic activity, through the reversing of hyperlipidemia, oxidative stress, and proinflammatory status in diabetic groups. Therefore, LUT might be a good remedy for the management or treatment of diabetes. Full article
(This article belongs to the Special Issue Analysis and Pharmacological Evaluation of New Synthetic and Natural Molecules in Drug Discovery)
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