Advances in Free Radical Scavenging Materials for Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1349

Special Issue Editors


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Guest Editor
School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea
Interests: biopolymers; nanocomposites; tissue engineering; antioxidant materials; free radical scavenging
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea
Interests: food packaging; biopolymers; active packaging; smart packaging; bionanocomposites; nanomaterials; sustainable materials; coatings; shelf life enhancement
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymeric nanocomposites are gaining popularity in applications ranging from biomedical materials to food packaging, waste-water treatment, cosmetics, and textiles. Although biopolymers are easy to process, degradable, and demonstrate apt physicochemical and functional properties, they cannot be used to address problems associated with free radicals. The generation of free radicals/reactive oxygen species (ROS) plays a major role in slowing down the healing of damaged tissues such as skin, bone, and muscle.

Adding certain active compounds or nanoparticles to biopolymeric scaffolds and hydrogels could aid in the scavenging of ROS. The resulting polymeric nanocomposites could reduce oxidative stress and free radicals. Therefore, this Special Issue focuses on showcasing the developments and advances in free radical-scavenging materials. The collected articles will serve a wide readership, from academia to industry, and highlight recent advances in this research area.

  • The synthesis and characterization of free radical-scavenging biopolymers and biomaterials.
  • Nanocomposites with antioxidant properties.
  • Free radical-scavenging nanoparticles.
  • Applications of antioxidant materials in wound healing, bone tissue engineering, and cardiac tissue engineering.
  • Applications of free radical-scavenging materials in organoid ex vivo models.
  • Antioxidant biopolymeric scaffolds for cancer therapy.

Dr. Shiv Dutt Purohit
Dr. Ruchir Priyadarshi
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biopolymers
  • nanocomposites
  • tissue engineering
  • antioxidant materials
  • free radical scavenging
  • antioxidant polyphenols

Published Papers (1 paper)

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Research

17 pages, 4115 KiB  
Article
Neuroprotective Effect of Platinum Nanoparticles Is Not Associated with Their Accumulation in the Brain of Rats
by Alexander Gennadievich Filippov, Valery Vasil’evich Alexandrin, Alexander Vladimirovich Ivanov, Alexander Alexandrovich Paltsyn, Nadezhda Borisovna Sviridkina, Edward Danielevich Virus, Polina Olegovna Bulgakova, Joanna Petrovna Burmiy and Aslan Amirkhanovich Kubatiev
J. Funct. Biomater. 2023, 14(7), 348; https://doi.org/10.3390/jfb14070348 - 29 Jun 2023
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Abstract
Platinum nanoparticles (nPts) have neuroprotective/antioxidant properties, but the mechanisms of their action in cerebrovascular disease remain unclear. We investigated the brain bioavailability of nPts and their effects on brain damage, cerebral blood flow (CBF), and development of brain and systemic oxidative stress (OS) [...] Read more.
Platinum nanoparticles (nPts) have neuroprotective/antioxidant properties, but the mechanisms of their action in cerebrovascular disease remain unclear. We investigated the brain bioavailability of nPts and their effects on brain damage, cerebral blood flow (CBF), and development of brain and systemic oxidative stress (OS) in a model of cerebral ischemia (hemorrhage + temporary bilateral common carotid artery occlusion, tBCAO) in rats. The nPts (0.04 g/L, 3 ± 1 nm diameter) were administered to rats (N = 19) intraperitoneally at the start of blood reperfusion. Measurement of CBF via laser Doppler flowmetry revealed that the nPts caused a rapid attenuation of postischemic hypoperfusion. The nPts attenuated the apoptosis of hippocampal neurons, the decrease in reduced aminothiols level in plasma, and the glutathione redox status in the brain, which were induced by tBCAO. The content of Pt in the brain was extremely low (≤1 ng/g). Thus, nPts, despite the extremely low brain bioavailability, can attenuate the development of brain OS, CBF dysregulation, and neuronal apoptosis. This may indicate that the neuroprotective effects of nPts are due to indirect mechanisms rather than direct activity in the brain tissue. Research on such mechanisms may offer a promising trend in the treatment of acute disorders of CBF. Full article
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