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Recent Advances in Clinical Management of Ischemic Stroke: Volume II
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Recent Advances in Clinical Management of Ischemic Stroke: Volume II

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 683

Special Issue Editors

Prof. Dr. Laurent Suissa

E-Mail Website1 Website2
Guest Editor
1. Stroke Unit, University Hospital, F-13005 Marseille, France
2. Centre de Recherche en CardioVasculaire et Nutrition (C2VN), F-13005 Marseille, France
Interests: ischemic stroke; neurology; atrial fibrillation; thrombectomy; stroke thrombolysis; neurological disorders; stroke rehabilitation; cerebral ischemia
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Anthony Faivre

E-Mail Website
Guest Editor
Military Teaching Saint Anne Hospital, F-83000 Toulon, France
Interests: ischemic stroke; neurology; atrial fibrillation; thrombectomy; stroke thrombolysis; neurological disorders; stroke rehabilitation; cerebral ischemia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are thrilled to announce the upcoming release of our second volume in this Special Issue series, titled "Recent Advances in Clinical Management of Ischemic Stroke Volume II". Stroke remains a significant public health concern, ranking among the leading causes of mortality, the primary cause of acquired disability in adults, and the second most prevalent cause of dementia after Alzheimer's disease.

Ischemic strokes resulting from large vessel occlusion (LVO) constitute a substantial proportion, accounting for 30-40% of all ischemic strokes. These cases are associated with the highest morbidity and mortality rates, underscoring the urgent need for advancements in LVO stroke management during both the acute phase and secondary prevention.

Over the past decade, significant strides have been made in improving the prognosis for LVO stroke patients. Remarkable progress in reperfusion therapies, including the use of mechanical thrombectomy in conjunction with intravenous thrombolysis, has led to improved clinical outcomes. While these advancements are undeniably groundbreaking, there remains a pressing need for further insights to enhance the management of LVO strokes. Furthermore, the precise identification of LVO stroke subtypes plays a pivotal role in determining the most effective secondary prevention strategies. Given that atrial fibrillation constitutes the primary source of LVO strokes, its detection presents a formidable challenge for stroke clinicians, particularly in cases of covert paroxysmal atrial fibrillation in patients presenting with embolic strokes of undetermined origin. Novel strategies are imperative to bolster secondary stroke prevention.

This forthcoming Special Issue in the JCM, dedicated to recent advancements in the clinical management of ischemic strokes, presents an invaluable opportunity to contribute fresh perspectives on LVO stroke management in both the acute phase and secondary prevention. We cordially invite you to be part of this exciting venture and share your expertise to further our collective understanding of this critical area.

We also invite you to visit our website to access the first volume of our Special Issue, available at the following link:

https://www.mdpi.com/journal/jcm/special_issues/stroke_ischemic

We extend our sincere gratitude for your continued support of our Special Issue and eagerly anticipate your contributions to future volumes, contributing to the ongoing progress in ischemic stroke research.

Prof. Dr. Laurent Suissa
Prof. Dr. Anthony Faivre
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ischemic stroke
  • thrombolysis
  • mechanical thrombectomy
  • atrial fibrillation
  • cerebrovascular disorders
  • stroke
  • secondary prevention

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Published Papers (1 paper)

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Research

10 pages, 529 KiB  
Article
Poor Prestroke Glycemic Control Increases the Rate of Symptomatic Intracranial Hemorrhage after Mechanical Thrombectomy
by Piotr Luchowski, Maciej Szmygin, Elzbieta Barton, Katarzyna Prus, Hanna Szmygin, Krzysztof Pyra, Remigiusz Ficek and Konrad Rejdak
J. Clin. Med. 2024, 13(5), 1227; https://doi.org/10.3390/jcm13051227 - 21 Feb 2024
Viewed by 502
Abstract
(1) Background: Diabetes is a well-established risk factor for acute ischemic stroke (AIS). This study evaluated the impact of prestroke glycemic control in diabetic patients on their 3-month clinical outcome after mechanical thrombectomy (MT). (2) Methods: AIS patients with a premorbid [...] Read more.
(1) Background: Diabetes is a well-established risk factor for acute ischemic stroke (AIS). This study evaluated the impact of prestroke glycemic control in diabetic patients on their 3-month clinical outcome after mechanical thrombectomy (MT). (2) Methods: AIS patients with a premorbid modified Rankin scale (mRS) score of 0–2 who were admitted within 6 h after stroke onset and treated with MT between January 2020 and August 2023 were retrospectively analyzed. The study evaluated the effect of prestroke glycemic control on the stroke severity, reperfusion rate, symptomatic intracranial hemorrhage (sICH) and favorable clinical outcome (modified Rankin scale score 0–2) at 3 months after endovascular treatment. (3) Results: A total of 364 patients were analyzed, with 275 cases of non-diabetes (ND), 66 of well-controlled diabetes (WCD) and 23 of poorly controlled diabetes (PCD). There was no significant difference in the baseline neurological deficit expressed according to the National Institutes of Health Stroke Scale among the three groups. The time from stroke onset to groin puncture was similar in the ND, WCD and PCD groups (median 215 min, 194.5 min and 222.5 min, respectively). There was no significant difference in the favorable 3-month clinical outcomes among these three groups (35.2% of ND patients, 42.4% of WCD patients and 39.1% of PCD patients) or full recovery (12.4% of ND patients, 11.0% of WCD patients and 17.4% of PCD patients). The rate of sICH was significantly higher in the PCD group as compared to the ND and WDP groups (21.7% of PCD patients versus 7.6% of ND patients, p = 0.038, and 6.0% of WCD patients, p = 0.046), but the 3-month mortality did not differ between the three groups (21.8% of ND group, 19.7% of WCD group and 26.1% of PCD group). (4) Conclusions: This study shows that poor prestroke glycemic control in AIS diabetic patients does not change the chance of a good clinical functional outcome after endovascular treatment. However, the increased risk of hemorrhagic complications in this group of patients should be considered. Full article
(This article belongs to the Special Issue Recent Advances in Clinical Management of Ischemic Stroke: Volume II)
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