Special Issue "The Role of Oxidant Stress in Disease"
Deadline for manuscript submissions: closed (30 November 2016) | Viewed by 57365
Interests: rare respiratory diseases; alpha-1 antitrypsin deficiency; primary ciliary dyskinesia; cystic fibrosis; idiopathic pulmonary fibrosis
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Oxidative stress refers to a condition caused by a persistent imbalance between antioxidants and oxidants, in favour of the latter. Under physiological conditions, reactive oxygen species (ROS) are constantly produced both by endogenous and exogenous sources in the organism where they are involved in physiological responses, such as signalling processes and defence mechanisms against infectious pathogens. However, its accumulation, either transitorily or chronically, leads to damage of the cellular components, producing changes in the cellular metabolism and its regulation, eventually leading to disease. Over the last 25 years, clinical and basic research has shown a relationship between oxidative stress and disease. In humans, oxidative stress is thought to be involved in the development of several diseases, such as cancer, cardiovascular and neurological diseases, rare diseases, and aging among many others. Once the implication of oxidative stress in a particular disease is demonstrated, the possibility of using antioxidant therapies in the clinical setting (both as antioxidant therapy and as prophylactics) is proposed. Therefore, the aim of these series of articles is to provide the reader with the latest knowledge on the biochemistry of oxidative stress and its role in the development of different human pathologies.
Dr. Francisco Dasí
Manuscript Submission Information
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- Oxidative stress
- reactive oxygen species
- reactive nitrogen species
- antioxidant therapies
- lipid peroxidation
- protein oxidation
- nucleic acid oxidation