Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.4
3.9
Journals
JCM
Special Issues
Clinical Updates in Sepsis and Septic Shock
share announcement

Clinical Updates in Sepsis and Septic Shock

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Emergency Medicine".

Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 7673

Special Issue Editors

Dr. Emilio Maseda

E-Mail Website
Guest Editor
Department Anesthesia and Critical Care, Hospital Universitario La Paz, Madrid, Spain
Interests: airway management; respiratory physiology; anesthesiology; intensive care; sepsis; septic shock; COVID-19; complicated intra-abdominal infection
Dr. Alejandro Suarez-de-la-Rica

E-Mail Website
Guest Editor
Department of Anesthesiology and Surgical Critical Care, Hospital Universitario de La Princesa, Madrid, Spain
Interests: intensive care; sepsis; septic shock; anesthesiology; infection; nutrition

Special Issue Information

Dear Colleagues,

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Patients with septic shock can be identified as having sepsis with persisting hypotension requiring vasopressors to maintain mean arterial pressure above 65mmHg and having a serum lactate level >2 mmol/L (18 mg/dL) despite adequate volume resuscitation.

The incidence of sepsis has increased, probably due to the progressive aging of the population, as several studies have demonstrated a relationship between age and incidence of sepsis and a larger number of people with disease comorbidities. Different studies have demonstrated a decrease in mortality related to sepsis over the years. Some possible reasons are improvements in diagnostic procedures, earlier and broader-spectrum antibiotic treatment, or more aggressive supportive therapy. In spite of the reduction in mortality, the absolute number of patients that die as a result of sepsis is increasing, resulting in more than 5 million deaths globally each year, consequently making it a major public health concern. As a result, novel therapeutic interventions for sepsis have been explored over the last several decades with inconsistent benefits.

Sepsis continues to be the primary cause of death from infection, and early recognition and appropriate treatment are required to improve outcomes.

Therefore, this Special Issue in Journal of Clinical Medicine aims to publish contributions from distinguished authors who actively experience innovations in the field of sepsis and septic shock and want to provide more solid scientific evidence. We welcome all original works and reviews. (Please note that case reports and short reviews are not accepted.)

Dr. Emilio Maseda
Dr. Alejandro Suárez de la Rica
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sepsis
  • septic shock
  • infection
  • antibiotic treatment
  • source control
  • early resuscitation
  • hemodynamic monitoring
  • fluids
  • vasopressors

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Editorial

Jump to: Research, Review

3 pages, 203 KiB  
Editorial
Precision Medicine in Sepsis and Septic Shock
by Alejandro Suarez-de-la-Rica and Emilio Maseda
J. Clin. Med. 2022, 11(18), 5332; https://doi.org/10.3390/jcm11185332 - 11 Sep 2022
Cited by 3 | Viewed by 2013
Abstract
Sepsis is defined as a potentially fatal organ dysfunction induced by a dysregulated host response to infection [...] Full article
(This article belongs to the Special Issue Clinical Updates in Sepsis and Septic Shock)

Research

Jump to: Editorial, Review

10 pages, 2267 KiB  
Article
Is Prehospital Assessment of qSOFA Parameters Associated with Earlier Targeted Sepsis Therapy? A Retrospective Cohort Study
by André Dankert, Jochen Kraxner, Philipp Breitfeld, Clemens Bopp, Malte Issleib, Christoph Doehn, Janina Bathe, Linda Krause, Christian Zöllner and Martin Petzoldt
J. Clin. Med. 2022, 11(12), 3501; https://doi.org/10.3390/jcm11123501 - 17 Jun 2022
Cited by 3 | Viewed by 1830
Abstract
Background: This study aimed to determine whether prehospital qSOFA (quick sequential organ failure assessment) assessment was associated with a shortened ‘time to antibiotics’ and ‘time to intravenous fluid resuscitation’ compared with standard assessment. Methods: This retrospective study included patients who were referred to [...] Read more.
Background: This study aimed to determine whether prehospital qSOFA (quick sequential organ failure assessment) assessment was associated with a shortened ‘time to antibiotics’ and ‘time to intravenous fluid resuscitation’ compared with standard assessment. Methods: This retrospective study included patients who were referred to our Emergency Department between 2014 and 2018 by emergency medical services, in whom sepsis was diagnosed during hospitalization. Two multivariable regression models were fitted, with and without qSOFA parameters, for ‘time to antibiotics’ (primary endpoint) and ‘time to intravenous fluid resuscitation’. Results: In total, 702 patients were included. Multiple linear regression analysis showed that antibiotics and intravenous fluids were initiated earlier if infections were suspected and emergency medical services involved emergency physicians. A heart rate above 90/min was associated with a shortened time to antibiotics. If qSOFA parameters were added to the models, a respiratory rate ≥ 22/min and altered mentation were independent predictors for earlier antibiotics. A systolic blood pressure ≤ 100 mmHg and altered mentation were independent predictors for earlier fluids. When qSOFA parameters were added, the explained variability of the model increased by 24% and 38%, respectively (adjusted R² 0.106 versus 0.131 for antibiotics and 0.117 versus 0.162 for fluids). Conclusion: Prehospital assessment of qSOFA parameters was associated with a shortened time to a targeted sepsis therapy. Full article
(This article belongs to the Special Issue Clinical Updates in Sepsis and Septic Shock)
►▼ Show Figures

Figure 1

11 pages, 2940 KiB  
Article
The Impact of Myosteatosis Percentage on Short-Term Mortality in Patients with Septic Shock
by June-sung Kim, Jiyeon Ha, Youn-Jung Kim, Yousun Ko, Taeyong Park, Kyung Won Kim and Won Young Kim
J. Clin. Med. 2022, 11(11), 3031; https://doi.org/10.3390/jcm11113031 - 27 May 2022
Cited by 3 | Viewed by 1566
Abstract
The impact of myosteatosis on septic patients has not been fully revealed. The aim of the study was to evaluate the impact of the myosteatosis area and percentage on the 28-day mortality in patients with septic shock. We conducted a single center, retrospective [...] Read more.
The impact of myosteatosis on septic patients has not been fully revealed. The aim of the study was to evaluate the impact of the myosteatosis area and percentage on the 28-day mortality in patients with septic shock. We conducted a single center, retrospective study from a prospectively collected registry of adult patients with septic shock who presented to the emergency department and performed abdominal computed tomography (CT) from May 2016 to May 2020. The myosteatosis area defined as the sum of low attenuation muscle area and intramuscular adipose tissue at the level of the third lumbar vertebra was measured by CT. Myosteatosis percentages were calculated by dividing the myosteatosis area by the total abdominal muscle area. Of the 896 patients, 28-day mortality was 16.3%, and the abnormal myosteatosis area was commonly detected (81.7%). Among variables of body compositions, non-survivors had relatively lower normal attenuation muscle area, higher low attenuation muscle area, and higher myosteatosis area and percentage than that of survivors. Trends of myosteatosis according to age group were different between the male and female groups. In subgroup analysis with male patients, the multivariate model showed that the myosteatosis percentage (adjusted OR 1.02 [95% CI 1.01–1.03]) was an independent risk factor for 28-day mortality. However, this association was not evident in the female group. Myosteatosis was common and high myosteatosis percentage was associated with short-term mortality in patients with septic shock. Our results implied that abnormal fatty disposition in muscle could impact on increased mortality, and this effect was more prominent in male patients. Full article
(This article belongs to the Special Issue Clinical Updates in Sepsis and Septic Shock)
►▼ Show Figures

Figure 1

Review

Jump to: Editorial, Research

14 pages, 1234 KiB  
Review
Biomarkers for the Prediction and Judgement of Sepsis and Sepsis Complications: A Step towards precision medicine?
by Thilo von Groote and Melanie Meersch-Dini
J. Clin. Med. 2022, 11(19), 5782; https://doi.org/10.3390/jcm11195782 - 29 Sep 2022
Cited by 8 | Viewed by 3218
Abstract
Sepsis and septic shock are a major public health concern and are still associated with high rates of morbidity and mortality. Whilst there is growing understanding of different phenotypes and endotypes of sepsis, all too often treatment strategies still only employ a “one-size-fits-all” [...] Read more.
Sepsis and septic shock are a major public health concern and are still associated with high rates of morbidity and mortality. Whilst there is growing understanding of different phenotypes and endotypes of sepsis, all too often treatment strategies still only employ a “one-size-fits-all” approach. Biomarkers offer a unique opportunity to close this gap to more precise treatment approaches by providing insight into clinically hidden, yet complex, pathophysiology, or by individualizing treatment pathways. Predicting and evaluating systemic inflammation, sepsis or septic shock are essential to improve outcomes for these patients. Besides opportunities to improve patient care, employing biomarkers offers a unique opportunity to improve clinical research in patients with sepsis. The high rate of negative clinical trials in this field may partly be explained by a high degree of heterogeneity in patient cohorts and a lack of understanding of specific endotypes or phenotypes. Moving forward, biomarkers can support the selection of more homogeneous cohorts, thereby potentially improving study conditions of clinical trials. This may finally pave the way to a precision medicine approach to sepsis, septic shock and complication of sepsis in the future. Full article
(This article belongs to the Special Issue Clinical Updates in Sepsis and Septic Shock)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop