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Dr. Enrica Mariano

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Department of Cardiovascular Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
Interests: interventional cardiology; pulmonary and arterial hypertension; takotsubo syndrome; pericarditis

Special Issue Information

Dear Colleagues,

This special issue focuses on the latest advances in the diagnosis and treatment of cardiomyopathy, a complex and potentially life-threatening heart disorder. Cardiomyopathy is characterized by structural and functional abnormalities of the heart muscle, leading to impaired heart function. This collection of articles presents cutting-edge research and provides clinical insights into the understanding, diagnosis, and management of various types of cardiomyopathy.

The articles in this special issue explore innovative diagnostic techniques, such as genetic testing, advanced imaging modalities, and biomarker analysis, which have revolutionized the early detection and risk stratification of cardiomyopathy. Furthermore, novel therapeutic approaches are discussed, including targeted pharmacological therapies, gene therapy, and regenerative medicine, offering new hope for patients with cardiomyopathy.

The articles gathered in this special issue provide a comprehensive overview of the recent breakthroughs in the field of cardiomyopathy, promoting early diagnosis and personalized treatment strategies. We anticipate that these advancements will contribute significantly to improving patient outcomes and ultimately reducing the burden of this debilitating condition.

Dr. Enrica Giuliana Mariano
Guest Editor

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Keywords

cardiomyopathy
diagnosis
treatment
advanced imaging
pharmacological therapy
personalized treatment

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11 pages, 1034 KiB

Open AccessArticle

Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index as Predictors of Mortality in ST-Elevation Myocardial Infarction

by Federica Marchi, Nataliya Pylypiv, Alessandra Parlanti, Simona Storti, Melania Gaggini, Umberto Paradossi, Sergio Berti and Cristina Vassalle

J. Clin. Med. 2024, 13(5), 1256; https://doi.org/10.3390/jcm13051256 - 22 Feb 2024

Viewed by 624

Abstract

(1) Background: The systemic inflammatory response index (SIRI; neutrophil count × monocyte/lymphocyte count), and the systemic immune-inflammation index (SII; platelet count × neutrophil count/lymphocyte count) are recently proposed biomarkers to assess the immune and inflammatory status. However, data on SIRI and SII are still relatively lacking and do not definitively and exhaustively define their role as predictors of an adverse prognosis in acute myocardial infarction (AMI). The aim of the present study was to evaluate SII and SIRI determinants as well as to assess SIRI and SII prognostic power in ST-elevation myocardial infarction (STEMI). (2) Methods: A total of 105 STEMI patients (74 males, 70 ± 11 years) were studied (median follow-up 54 ± 25 months, 24 deaths). (3) Results: The main determinants of SIRI and SII were creatinine and brain natriuretic peptide (BNP) (multivariate regression). Patients with higher SIRI (>75th percentile, 4.9) and SII (>75th percentile, 1257.5) had lower survival rates than those in the low SIRI/SII group (Kaplan–Meier analysis). Univariate Cox regression revealed that high SIRI and SII were associated with mortality (HR: 2.6, 95% CI: 1.1–5.8, p < 0.05; 2.2, 1–4.9, p ≤ 0.05, respectively); however, these associations lost their significance after multivariate adjustment. (4) Conclusions: SIRI and SII association with mortality was significantly affected by confounding factors in our population, especially creatinine and BNP, which are associated with both the inflammatory indices and the outcome. Full article

(This article belongs to the Special Issue Recent Advances in the Diagnosis and Treatment of Cardiomyopathy)

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