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New Insights in Management of Constipation
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New Insights in Management of Constipation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 5709

Special Issue Editor

Dr. Ugo Grossi

E-Mail Website
Guest Editor
Department of Surgery, Oncology and Gastroenterology, DISCOG, University of Padua, Padua, Italy
Interests: inflammatory bowel disorders; pelvic floor disorders; constipation; gastrointestinal diseases; laparoscopic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Constipation is one of the most frequent gastrointestinal symptoms exposing patients to severe health impairment, decreased quality of life, and psychological distress. The management of constipation is a major challenge due to its high prevalence and lack of widespread specialist expertise. This Special Issue will mainly focus on the hot topics of constipation management to exhibit the latest results from diagnosis to treatment (nonoperative therapy or operative therapy). Original research articles are especially welcome, demonstrating innovative findings with the potential of enhancing the clinical capability of diagnosing and treating constipation among different patient groups. Additionally, submissions of high-interest review articles are encouraged.

Dr. Ugo Grossi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • constipation
  • chronic idiopathic constipation
  • slow-transit constipation
  • opioid-induced constipation
  • Lewy body constipation
  • diagnosis
  • treatment

Published Papers (2 papers)

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Review

11 pages, 1393 KiB  
Review
Management of Constipation in Hospitalized Patients
by Gregory S. Sayuk, Qi T. Yu and Corey Shy
J. Clin. Med. 2023, 12(19), 6148; https://doi.org/10.3390/jcm12196148 - 23 Sep 2023
Cited by 1 | Viewed by 3587
Abstract
Constipation is frequently encountered in hospital settings and can have potentially serious consequences yet is often underrecognized and undertreated. Opioid-induced constipation is a common cause of constipation in hospitalized patients. Opioids induce constipation through agonistic effects on enteric µ-opioid receptors. This review aims [...] Read more.
Constipation is frequently encountered in hospital settings and can have potentially serious consequences yet is often underrecognized and undertreated. Opioid-induced constipation is a common cause of constipation in hospitalized patients. Opioids induce constipation through agonistic effects on enteric µ-opioid receptors. This review aims to provide insight on the identification and management of constipation in inpatient settings, with a particular focus on opioid-induced constipation. Constipation assessment should be routinely initiated at hospital admission and can be facilitated by thorough symptom assessments; relevant patient history, including recent medication use; physical examination; and patient assessment tools developed to evaluate the impact of constipation. Management of opioid-induced constipation should begin with ensuring adequate hydration and electrolyte balance and encouraging patient mobilization. Other treatments may include laxatives, enemas, intestinal secretagogues, peripherally acting µ-opioid receptor antagonists, and manual disimpaction. Surgical intervention may be required for some patients as a salvage therapy in severe, refractory cases. Full article
(This article belongs to the Special Issue New Insights in Management of Constipation)
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11 pages, 280 KiB  
Review
Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future
by Gabrio Bassotti, Vincenzo Villanacci and Maura Corsetti
J. Clin. Med. 2023, 12(4), 1702; https://doi.org/10.3390/jcm12041702 - 20 Feb 2023
Cited by 3 | Viewed by 1667
Abstract
Despite great progress in pharmaceutical research, the medical treatment of chronic idiopathic constipation is far from ideal. The aim of the present article was to review literature data, focusing on poorly studied or commercially unavailable/unapproved drugs potentially useful for the treatment of chronic [...] Read more.
Despite great progress in pharmaceutical research, the medical treatment of chronic idiopathic constipation is far from ideal. The aim of the present article was to review literature data, focusing on poorly studied or commercially unavailable/unapproved drugs potentially useful for the treatment of chronic idiopathic constipation in adults. An extensive online literature search was conducted using the keywords “chronic constipation”, “colon”, “constipation”, “drugs”, “laxatives”, and “treatment”, in various combinations between January 1960 and December 2022. The literature search showed the presence of some drugs whose efficacy has only recently been demonstrated by modern investigations, and which are likely to be incorporated into future guidelines, of others that are proven effective and potentially effective on constipated patients but limited by small or relatively old studies, or by side effects which could be used in experienced hands, and of others that might be useful but lack a solid scientific background. Looking into the future for patients with chronic constipation might add some more tools to the therapeutic portfolio, especially for certain subgroups of these patients. Full article
(This article belongs to the Special Issue New Insights in Management of Constipation)
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