Association between Restless Leg Syndrome (RLS) and Major Diseases: Current Research and Outlook

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (19 August 2019)

Special Issue Editor


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Guest Editor
Department of Neurology, Hospital Universitario del Sureste, Ronda del Sur 10, E28500 Arganda del Rey, Madrid, Spain
Interests: movement disorders; Parkinson’s disease; neurodegenerative diseases; restless leg syndrome; genetics; biochemistry; risk factors
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Special Issue Information

Dear Colleagues,

Restless leg syndrome or Willis–Ekbom disease (RLS/WED) is a highly prevalent medical condition. From an etiological point of view, it is usually classified as primary (idiopathic) or secondary. In recent years, many studies have addressed the role of genetic factors and the neurochemical features of idiopathic RLS/WED. However, less attention has been paid to secondary cases of this disease. For this reason, we think that the elaboration of a Special Issue on the association between RLS/WED and major (mainly systemic) diseases could be interesting, especially for general practicioners and physicians specialized in Internal Medicine. In this Special Issue, we will focus on the current knowledge of many diseases that could be associated with or increase the risk of suffering from RLS/WED.

Prof. Dr. Felix Javier Jiménez Jiménez
Guest Editor

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Keywords

  • Movement disorders
  • Restless legs syndrome
  • Genetics
  • Biochemistry
  • Risk factors

Published Papers (1 paper)

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Research

13 pages, 660 KiB  
Article
Restless Leg Syndrome in Peripheral Artery Disease: Prevalence among Patients with Claudication and Benefits from Low-Intensity Exercise
by Nicola Lamberti, Pablo Jesús López-Soto, María Aurora Rodríguez-Borrego, Sofia Straudi, Nino Basaglia, Paolo Zamboni, Roberto Manfredini and Fabio Manfredini
J. Clin. Med. 2019, 8(9), 1403; https://doi.org/10.3390/jcm8091403 - 6 Sep 2019
Cited by 3 | Viewed by 3320
Abstract
Restless leg syndrome (RLS) disrupts sleep, affecting the quality of life of patients with various chronic diseases. We assessed the prevalence of RLS in peripheral artery disease (PAD) patients and the effects of a pain-free exercise program. A total of 286 patients with [...] Read more.
Restless leg syndrome (RLS) disrupts sleep, affecting the quality of life of patients with various chronic diseases. We assessed the prevalence of RLS in peripheral artery disease (PAD) patients and the effects of a pain-free exercise program. A total of 286 patients with claudication were enrolled in a home-based low-intensity exercise program prescribed at the hospital. RLS was determined through standardized questions. Hemodynamics, degree of calf deoxygenation, and mobility were assessed using the ankle-brachial-index, a treadmill test assisted by near-infrared spectroscopy and the 6-min walk test, respectively. During hospital visits, persistence of RLS, adherence to exercise, hemodynamics, and mobility were assessed. At the enrollment, 101 patients (35%) presented RLS, with higher prevalence among females (p = 0.032). Compared to RLS-free patients, they showed similar hemodynamics but more severe calf deoxygenation (p < 0.001) and lower mobility (p = 0.040). Eighty-seven RLS patients (83%) reported the disappearance of symptoms after 39 (36−70) days of exercise. This subgroup, compared to nonresponders, showed higher adherence (p < 0.001), hemodynamic (p = 0.041), and mobility improvements (p = 0.003). RLS symptoms were frequent in PAD but were reduced by a pain-free walking exercise aimed at inducing peripheral aerobic adaptations. The concomitant recovery of sleep and mobility may represent a synergistic action against the cardiovascular risk in PAD. Full article
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