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Regenerative Medicine for Longevity and Aesthetics
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Regenerative Medicine for Longevity and Aesthetics

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine".

Deadline for manuscript submissions: closed (25 April 2023) | Viewed by 11473

Special Issue Editors

Dr. Dominik Duscher

E-Mail Website
Guest Editor
Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tuebingen, Schnarrenbergstrasse 95, 72076 Tübingen, Germany
Interests: plastic surgery; regenerative medicine; stem cells; tissue engineering; biomaterials; clinical translation
Special Issues, Collections and Topics in MDPI journals
Dr. Michael S. Hu

E-Mail Website
Guest Editor
Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Interests: plastic and reconstructive surgery, particularly craniofacial surgery, microsurgery, and general reconstructive surgery.
Special Issues, Collections and Topics in MDPI journals
Dr. Zeshaan Naeem Maan

E-Mail
Guest Editor
Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Interests: plastic and reconstructive surgery

Special Issue Information

Dear Colleagues,

Understanding the aging of each of the five main levels of our biology (cell, tissue, organ, organ system and organism) is the core task of the new branch of research longevity medicine. The search for a single cause—and therefore a cure—for aging has been replaced by the view that it is a highly complex process with many causes. Deciphering this process and the responsible causes is the most exciting task of our time.

The latest findings from longevity research are frequently intertwined with regenerative medicine and aesthetic applications. In this Special Issue, we would therefore like to shed light on this revolutionary field of research, particularly within its interface with regenerative aesthetic medicine and surgery.

Dr. Dominik Duscher
Dr. Michael S. Hu
Dr. Zeshaan Naeem Maan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • tissue engineering
  • stem cells
  • aesthetics
  • plastic and reconstructive surgery
  • longevity

Published Papers (3 papers)

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Research

11 pages, 2118 KiB  
Article
Nagor Impleo Round Silicone Gel Breast Implants: Early Outcome Analysis after 340 Primary Breast Augmentations
by Maximilian Zaussinger, Dominik Duscher and Georg M. Huemer
J. Clin. Med. 2023, 12(11), 3708; https://doi.org/10.3390/jcm12113708 - 27 May 2023
Cited by 1 | Viewed by 1243
Abstract
For decades, implant-based breast augmentation has been one of the most performed surgical procedures for cosmetic purposes around the world. Hence, novel manufactured implants should be critically investigated to prove them safe and effective. Here, the authors describe the first independently conducted clinical [...] Read more.
For decades, implant-based breast augmentation has been one of the most performed surgical procedures for cosmetic purposes around the world. Hence, novel manufactured implants should be critically investigated to prove them safe and effective. Here, the authors describe the first independently conducted clinical study on Nagor Impleo textured round breast implants. For this retrospective study, outcomes of 340 consecutive female patients undergoing primary cosmetic breast augmentation were analyzed. Demographic and surgical data as well as outcomes and complications were evaluated. Furthermore, a survey concerning effectiveness and aesthetic satisfaction after breast augmentation was examined. All 680 implants were placed in a submuscular plane with incisions at the inframammary fold. The main indications for surgery were hypoplasia and hypoplasia with asymmetry. The mean implant volume was 390 cc and the main type of projection was high profile. The most common complications were hematoma and capsular contracture (0.9 percent, respectively). The overall revision rate for complications was 2.4%. Additionally, almost all patients showed increased quality of life and aesthetic satisfaction after a breast augmentation. Hence, all patients would undergo breast augmentation again with these newly launched devices. Nagor Impleo implants demonstrate a low complication rate and high safety profile. Although high aesthetic satisfaction and quality of life results were achieved, analysis of an even larger series over a longer period of time would be beneficial to evaluate the reliability of this implant. Full article
(This article belongs to the Special Issue Regenerative Medicine for Longevity and Aesthetics)
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11 pages, 1800 KiB  
Article
A Novel Hair Restoration Technology Counteracts Androgenic Hair Loss and Promotes Hair Growth in A Blinded Clinical Trial
by Dominik Thor, Andrea Pagani, Julia Bukowiecki, Khosrow S. Houschyar, Stig-Frederik T. Kølle, Saranya P. Wyles and Dominik Duscher
J. Clin. Med. 2023, 12(2), 470; https://doi.org/10.3390/jcm12020470 - 06 Jan 2023
Cited by 1 | Viewed by 6232
Abstract
Androgenic alopecia (AGA) is a genetically predetermined condition that occurs as a result of stepwise miniaturization of the dermal papilla. During this process, the hair follicle suffers from increasing malnutrition and eventually dies, causing progressive hair loss. We recently highlighted that HIF-1α modulation [...] Read more.
Androgenic alopecia (AGA) is a genetically predetermined condition that occurs as a result of stepwise miniaturization of the dermal papilla. During this process, the hair follicle suffers from increasing malnutrition and eventually dies, causing progressive hair loss. We recently highlighted that HIF-1α modulation may counteract hair loss. Here, we aim to demonstrate the positive influence of Tomorrowlabs HIF strengthening factor [HSF] hair restoration technology on hair biology in a monocentric blinded clinical trial over a total period of 9 months. A trial with 20 subjects (4 female and 16 male) and once-daily application of [HSF] hair restoration technology to the scalp was conducted. To assess the tolerability and efficacy of [HSF], testing included dermatological assessment, determination of hair loss by counting after combing, macro images of the head and TrichoScan evaluation of hair density as well as the proportion of anagen hair versus telogen hair. The clinical data show Tomorrowlabs [HSF] hair restoration to be safe and effective to counteract AGA. The use of Tomorrowlabs [HSF] hair restoration resulted in improvements in the clinical parameters of hair quality such as thickness (+7.2%), hair density (+14.3%) and shine and elasticity (+20.3%) during the test period. The effectiveness of the test product was further determined by a significant reduction in hair loss of an average of 66.8% in treatment-responsive subjects after 6 months and an increase in hair growth reaching up to 32.5%, with an average percentage change of 8.4% in all participants and 10.8% in the responsive patients (85% of the study cohort) after 9 months on TrichoScan evaluation. The hair growth cycle was harmonized with the result of an average anagen hair percentage increase of +8.0% and telogen hair percentage reduction of −14.0% shown in the test area. Applicable for both sexes in an alcohol-free formulation, beneficial to scalp health and free of complications or side effects, this novel product provides objectively measurable results counteracting hair loss paired with an improved look and feel of the hair. Full article
(This article belongs to the Special Issue Regenerative Medicine for Longevity and Aesthetics)
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11 pages, 1168 KiB  
Article
Micro-Focused Ultrasound Therapy in Patients with Urogenital Atrophy and Vaginal Laxity
by Piotr Kolczewski, Mateusz Kozłowski and Aneta Cymbaluk-Płoska
J. Clin. Med. 2022, 11(23), 6980; https://doi.org/10.3390/jcm11236980 - 26 Nov 2022
Cited by 2 | Viewed by 3010
Abstract
Vaginal laxity (VL) and genitourinary syndromes of menopause (GSM) create physical, psychological, and functional problem for women and their partners. We aimed to evaluate the efficacy and safety of micro-focused ultrasound (MFU) therapy performed twice in the vaginal canal in a patients with [...] Read more.
Vaginal laxity (VL) and genitourinary syndromes of menopause (GSM) create physical, psychological, and functional problem for women and their partners. We aimed to evaluate the efficacy and safety of micro-focused ultrasound (MFU) therapy performed twice in the vaginal canal in a patients with VL and GSM. A total of 20 women with GSM and VL were treated with MFU Ultravera by Hironic. The treatment course consisted of two vaginal applications of MFU at an interval of 6 weeks. The clinical effects of the protocol were evaluated using the Vaginal Laxity Questionnaire (VLQ), the Vaginal Health Index (VHI), and the Female Sexual Function Index (FSFI). The overall values of the vaginal laxity evaluation for the total subject population showed a statistically significant improvement between the baseline and the findings at 3 and 6 months after treatment. The effect of therapy was consistent across all domains of FSFI. It peaked at the 6 week follow-up visit (from 26.5 to 32) and plateaued at 12 weeks and 6 months. There was a significant VHI improvement over time, with the greatest and most significant change between the study entry and 21 days after treatment; the VHI score leveled off up to 3 months after the procedures. MFU therapy, performed twice in the vaginal canal, showed promising efficacy and safety profiles, meriting further investigation. Full article
(This article belongs to the Special Issue Regenerative Medicine for Longevity and Aesthetics)
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