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Advances in Postural Orthostatic Tachycardia Syndrome (POTS)
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Advances in Postural Orthostatic Tachycardia Syndrome (POTS)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 5526

Special Issue Editors

Dr. Fabrizio Ricci

E-Mail Website
Guest Editor
Department of Neuroscience, Imaging and Clinical Sciences, “G.d’Annunzio” University of Chieti-Pescara, Chieti, Italy
Interests: cardiovascular magnetic resonance; multi-modality cardiac imaging; heart valve disease; coronary artery disease; sudden cardiac death; mitral valve prolapse; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac amyloidosis; arrhythmogenic cardiomyopathy; sports cardiology; heart failure; cardiovascular autonomic dysfunction; COVID-19
Special Issues, Collections and Topics in MDPI journals
Dr. Madeleine Johansson

E-Mail Website
Guest Editor
1. Department of Clinical Sciences, Lund University, Malmö, Sweden
2. Department of Cardiology, Skåne University Hospital, Malmö, Sweden
Interests: cardiovascular disease; orthostatic hypotension; syncope; POTS; vascular ageing; aortic stiffness; cardiovascular autonomic dysfunction; COVID-19

Special Issue Information

Dear Colleagues,

We are pleased to introduce a Special Issue in the Journal of Clinical Medicine, titled "Advances in Postural Orthostatic Tachycardia Syndrome (POTS)".

POTS is a common and therapeutically challenging condition affecting numerous people worldwide. POTS is a chronic multi-system disorder involving the autonomic nervous system that is characterized by an excessive increase in heart rate upon standing, accompanied by persistent orthostatic intolerance symptoms. POTS predominantly affects young women, and it has a considerable impact on patients’ health-related quality of life.

Pathophysiology is incompletely understood, which is likely responsible for the limited data on effective treatments. Despite ongoing research efforts, substantial knowledge gaps remain, and a scarcity of validated interventions hinders healthcare professionals from providing optimal care to POTS patients. Focused research studies on the pathophysiology and treatment of POTS have the potential to significantly improve the lives of patients with POTS.

In this Special Issue, we welcome the submission of your original research and review articles focusing on the latest advances and developments in POTS. Particularly, we encourage submissions on the following POTS-related topics:

  • Biomarkers;
  • Pathophysiology;
  • Genetics;
  • Symptoms and quality of life;
  • Antibodies and immunology;
  • Pharmacological interventions;
  • Non-pharmacologic management.

We eagerly await your valuable contributions.

Sincerely,
Dr. Fabrizio Ricci
Dr. Madeleine Johansson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • postural orthostatic tachycardia syndrome
  • biomarkers
  • pathophysiology
  • treatment
  • autoimmunity
  • autonomic dysfunction
  • symptoms
  • long-COVID-19

Published Papers (2 papers)

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Research

13 pages, 886 KiB  
Article
Sexual Dysfunction in Postural Orthostatic Tachycardia Syndrome (POTS): A Cross-Sectional, Case-Control Study
by Svetlana Blitshteyn, Anna Lange, Chelsea Corinaldi, Paige Guy and Jill Brook
J. Clin. Med. 2024, 13(8), 2274; https://doi.org/10.3390/jcm13082274 - 14 Apr 2024
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Abstract
Background: We aimed to determine whether patients with postural orthostatic tachycardia syndrome (POTS) have sexual dysfunction compared to age-matched healthy controls. Methods: Utilizing online COMPASS-31 to evaluate dysautonomia symptom severity, Beck’s Depression Inventory Second Edition (BDII), Female Sexual Function (FSF), and International Index [...] Read more.
Background: We aimed to determine whether patients with postural orthostatic tachycardia syndrome (POTS) have sexual dysfunction compared to age-matched healthy controls. Methods: Utilizing online COMPASS-31 to evaluate dysautonomia symptom severity, Beck’s Depression Inventory Second Edition (BDII), Female Sexual Function (FSF), and International Index of Erection Function (IIEF) questionnaires, we compared sexual function scores in patients with POTS to scores obtained from sex- and age-matched healthy controls via a cross-sectional case–control study. Results: A total of 160 women with POTS, mean age 30.2 ± 7.9 (range 21–50 years), had lower FSF scores than 62 healthy age-matched female controls. IIEF scores in 29 male patients with POTS with a mean age of 30.1 ± 6.0 (range 21–47) were significantly lower than in 27 healthy age-matched male controls. Female POTS patients had significantly lower scores in the sub-domains of desire, arousal, and satisfaction, while male POTS patients had significantly lower scores in erectile and orgasmic function, desire, and satisfaction than healthy controls. Predictive factors of sexual dysfunction were depression in women and age in men. The severity of autonomic symptoms correlated with sexual dysfunction in women, but this effect disappeared after controlling for depression. Conclusions: Compared to healthy controls, women and men with POTS have significant sexual dysfunction, which needs to be considered in the diagnostic and therapeutic approaches as part of comprehensive patient care. Full article
(This article belongs to the Special Issue Advances in Postural Orthostatic Tachycardia Syndrome (POTS))
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11 pages, 2850 KiB  
Article
Evidence for Impaired Renin Activity in Postural Orthostatic Tachycardia Syndrome
by Jasmina Medic Spahic, Ingrid Yao Mattisson, Viktor Hamrefors, Madeleine Johansson, Fabrizio Ricci, Jan Nilsson, Olle Melander, Richard Sutton and Artur Fedorowski
J. Clin. Med. 2023, 12(14), 4660; https://doi.org/10.3390/jcm12144660 - 13 Jul 2023
Cited by 2 | Viewed by 2362
Abstract
Background: Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous condition predominantly affecting autonomic control of the cardiovascular system. Its extensive symptom diversity implies multi-organ involvement that interacts in ways still requiring full exploration. Current understanding of POTS pathophysiology suggests alterations in the renin–angiotensin–aldosterone [...] Read more.
Background: Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous condition predominantly affecting autonomic control of the cardiovascular system. Its extensive symptom diversity implies multi-organ involvement that interacts in ways still requiring full exploration. Current understanding of POTS pathophysiology suggests alterations in the renin–angiotensin–aldosterone system as a possible contributing factor. Therefore, we investigated the relationship between the activity of the renin–angiotensin–aldosterone system and hemodynamic parameters in a cohort of POTS patients and controls recruited at a tertiary referral center. Methods: The case-control study included 46 patients with POTS (27 ± 9 years), and 48 healthy controls (30 ± 9 years) without orthostatic intolerance. Plasma renin activity, expressed as angiotensin I generation, and plasma aldosterone were measured by enzyme-linked immunosorbent assay and were correlated with hemodynamic parameters obtained during active standing tests. Results: Renin activity was significantly downregulated in POTS patients compared to healthy individuals (median, 3406 ng/mL vs. 9949 ng/mL, p < 0.001), whereas aldosterone concentration did not differ between POTS and healthy controls (median, 218 pmol/L vs. 218 pmol/L, p = 0.26). A significant inverse correlation between renin activity and supine and orthostatic blood pressure levels was observed in healthy individuals (p < 0.05 for all), but not in POTS patients. Conclusions: Renin activity, but not aldosterone concentration, is downregulated in patients with POTS. Moreover, renin activity in POTS is dissociated from supine and standing blood pressure levels in contrast to healthy individuals. These findings suggest impaired renin function in POTS, which may direct future therapeutic approaches. Full article
(This article belongs to the Special Issue Advances in Postural Orthostatic Tachycardia Syndrome (POTS))
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