Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.4
3.9
Journals
JCM
Special Issues
Allergic and Eosinophilic Diseases: Diagnosis, Treatment, and Management
share announcement

Allergic and Eosinophilic Diseases: Diagnosis, Treatment, and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 4318

Special Issue Editor

Dr. Aikaterini Detoraki

E-Mail Website
Guest Editor
Division of Internal Medicine and Clinical Immunology, Department of Internal Medicine and Clinical Complexity, Azienda Ospedaliera Universitaria Federico II, Via S. Pansini 5, 80131 Naples, Italy
Interests: allergy; eosinophilic diseases; immunology; clinical immunology; asthma

Special Issue Information

Dear Colleagues,

Allergic and eosinophilic diseases represent a collection of disorders including bronchial asthma, atopic dermatitis (AD), allergic rhinitis (AR), conjunctivitis, chronic rhinosinusitis with/without nasal polyps (CRSwNP/CRSsNP), food allergy, eosinophilic esophagitis (Eo) and other conditions mediated by eosinophilic inflammation.

These disorders affect over 25% of the population in industrialized countries and are rising in prevalence in developing countries, representing an important socioeconomic burden impacting patients’ health-related QoL.

Allergic/eosinophilic diseases are mediated by T2-driven pathophysiological mechanisms, shared across multiple allergic/eosinophilic disorders that often overlap in the same patient. The complexity of allergic/eosinophilic disorders in terms of treatment options and guideline indications highlights the need to identify specific advice to optimize the management of different types of patients who could benefit from the current standard of care medication, prevention strategies (allergen immunotherapy) or biological therapy.

This Special Issue aims to discuss new knowledge in clinical allergic/eosinophilic disorders in terms of diagnosis, treatment and management and welcomes inputs from researchers in different disciplines who feel they can contribute to this discussion.

Dr. Aikaterini Detoraki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergy
  • eosinophilic diseases
  • immunology
  • clinical immunology
  • asthma
  • diagnosis
  • treatment
  • management

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

12 pages, 7345 KiB  
Article
Expression of Immunoglobulin G4 in Eosinophilic Esophagitis
by See-Young Lee, Ji-Hae Nahm, Min-Jae Kim, Yuna Kim, Jie-Hyun Kim, Young-Hoon Youn and Hyojin Park
J. Clin. Med. 2024, 13(8), 2175; https://doi.org/10.3390/jcm13082175 - 10 Apr 2024
Viewed by 564
Abstract
Background: Eosinophilic esophagitis (EoE) is a disease that has been subcategorized into two endoscopic phenotypes: inflammatory and fibrostenotic. Moreover, studies have shown a link between EoE and immunoglobulin G4 (IgG4), a subclass of the immunoglobulin G (IgG) antibody. In this study, we [...] Read more.
Background: Eosinophilic esophagitis (EoE) is a disease that has been subcategorized into two endoscopic phenotypes: inflammatory and fibrostenotic. Moreover, studies have shown a link between EoE and immunoglobulin G4 (IgG4), a subclass of the immunoglobulin G (IgG) antibody. In this study, we aimed to evaluate the relationship between histologic IgG4 expression and endoscopic phenotypes in patients with EoE. Methods: This case-control study included patients diagnosed with EoE (n = 19) and patients with non-obstructive dysphagia without abnormal findings as controls (NOD; n = 12). The EoE group was further divided into three subgroups based on endoscopic phenotype: inflammatory, fibrostenotic, or combined. Retrospective examination of endoscopic findings and pathological slides was performed to analyze IgG4 staining. Results: Histological analysis revealed a significant difference in IgG4 cell count (15.00 vs. 0.58, p = 0.003) and eosinophil cell count (84.67 vs. 0.08, p < 0.001) between the EoE and NOD groups. Symptom manifestation and blood test results were similar across all three endoscopic EoE phenotypes. However, histological analysis revealed a significant difference in IgG4 cell count between the inflammatory, fibrostenotic, and combined phenotypes (4.13 vs. 17.6 vs. 59.7, p = 0.030). Conclusions: IgG4 expression was higher in EoE patients than in those with NOD, the highest being in the combined phenotype subgroup. These findings emphasize the important role of endoscopic and histological examination in diagnosing EoE and the need for further research in this area. Full article
(This article belongs to the Special Issue Allergic and Eosinophilic Diseases: Diagnosis, Treatment, and Management)
►▼ Show Figures

Graphical abstract

17 pages, 5232 KiB  
Article
Eosinophilic Patterns in Patients with Seasonal Allergy Affected by Bronchial Asthma and Rhinitis/Rhinosinusitis: Efficacy of Benralizumab in Patients with the Persistent Pattern
by Valentina D’Aiuto, Ilaria Mormile, Francescopaolo Granata, Antonio Romano, Francesca Della Casa, Caterina D’Onofrio, Valentina Marzio, Gabriele Mignogna, Luigi Califano, Amato de Paulis and Francesca Wanda Rossi
J. Clin. Med. 2024, 13(3), 754; https://doi.org/10.3390/jcm13030754 - 28 Jan 2024
Viewed by 1151
Abstract
Background: Eosinophilia can be influenced by multiple factors. This study aims to set a protocol for monitoring blood absolute eosinophil count (AEC) in patients with seasonal allergy affected by bronchial asthma (BA), allergic rhinitis (AR), or chronic rhinosinusitis with or without nasal polyposis [...] Read more.
Background: Eosinophilia can be influenced by multiple factors. This study aims to set a protocol for monitoring blood absolute eosinophil count (AEC) in patients with seasonal allergy affected by bronchial asthma (BA), allergic rhinitis (AR), or chronic rhinosinusitis with or without nasal polyposis (CRSw/sNP). Methods: We planned a total of four annual blood samples to measure AEC in- and out-seasonal pollen exposure (i.e., one measurement every three months for one year). Results: We identified two distinct groups of patients (non-eosinophilic and eosinophilic). Patients in the eosinophilic group presented with four different patterns (episodic, transient, floating, and persistent). Most patients with episodic, transient, and floating patterns were affected by mild allergy and the increase in eosinophils was related to allergen exposure. In contrast, patients with the persistent pattern mostly presented with more severe allergy (i.e., severe BA and relapsing CRSwNP) and the eosinophilia was unrelated to allergen exposure. The subgroup of patients with severe BA, relapsing CRSwNP, and persistent eosinophilc pattern were treated with benralizumab, which induced a noteworthy improvement in both severe BA and CRSwNP. Conclusions: Multiple AEC measurements in patients with seasonal allergy can better reflect patient’s eosinophilic status and help define the relationship of AEC enhancement with allergen exposure. Full article
(This article belongs to the Special Issue Allergic and Eosinophilic Diseases: Diagnosis, Treatment, and Management)
►▼ Show Figures

Figure 1

11 pages, 3805 KiB  
Article
Early Ear, Nose and Throat Manifestations in Eosinophilic Granulomatosis with Poliangioitis: Results from Our Cohort Group and Literature Review
by Mario D’Onofrio, Daniele La Prova, Maria Rosaria Galdiero, Elena Cantone, Eugenio Tremante, Massimo Mascolo, Vittoria Barbieri, Claudio Di Nola, Giuseppe Spadaro, Amato de Paulis and Aikaterini Detoraki
J. Clin. Med. 2023, 12(22), 6967; https://doi.org/10.3390/jcm12226967 - 07 Nov 2023
Viewed by 1019
Abstract
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, systemic necrotizing vasculitis affecting small-to-medium-sized vessels. EGPA’s clinical manifestations are heterogeneous, affecting different organs and systems, and the upper respiratory tract can be affected by ear, nose and throat (ENT) involvement. The aim of our [...] Read more.
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, systemic necrotizing vasculitis affecting small-to-medium-sized vessels. EGPA’s clinical manifestations are heterogeneous, affecting different organs and systems, and the upper respiratory tract can be affected by ear, nose and throat (ENT) involvement. The aim of our study was to assess type manifestations at the time of diagnosis in a cohort of EGPA patients and correlate findings with baseline variables (sex, age, antineutrophil cytoplasmic antibodies—ANCA-status) and literature reports. The main ENT manifestations in our patients at the time of diagnosis were: chronic rhinosinusitis with nasal polyposis (CRSwNP) (52%), turbinate hypertrophy (48%), nasal swelling (40%), rhinorrhea (40%), chronic rhinosinusitis without nasal polyposis (CRSsNP) (32%), nasal bone deformities (32%), nasal crusts (20%), nasal mucosal ulcers (12%), corditis (12%), hoarseness/dysphonia (12%), hearing loss (12%), mucoceles (4%) and eosinophilic rhinitis (4%). No correlations were found between sex, age, ANCA status and ENT clinical manifestations. A polymorphic ENT involvement is often observed in the early stages of EGPA. The presence of nasal, sinus, ear and/or laryngeal manifestations in patients with asthma and hypereosinophilia, independently of sex, age or ANCA status, should raise an alert for further investigation and differential diagnosis for EGPA. ENT specialists should be aware of their leading position in this diagnostic race. Full article
(This article belongs to the Special Issue Allergic and Eosinophilic Diseases: Diagnosis, Treatment, and Management)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

9 pages, 220 KiB  
Review
Recurrent Kounis Syndrome: A Case Report and Literature Review
by Raffaele Brancaccio, Laura Bonzano, Alessia Cocconcelli, Rostyslav Boyko, Giuseppe Ienopoli and Alberico Motolese
J. Clin. Med. 2024, 13(6), 1647; https://doi.org/10.3390/jcm13061647 - 13 Mar 2024
Viewed by 742
Abstract
Kounis syndrome is a condition where inflammatory cells (mostly mast cells with the contribution of macrophages and T-lymphocytes) cause an acute coronary syndrome. Kounis syndrome comes in four variants: type I in patients with normal coronary arteries; type II in patients with inactive [...] Read more.
Kounis syndrome is a condition where inflammatory cells (mostly mast cells with the contribution of macrophages and T-lymphocytes) cause an acute coronary syndrome. Kounis syndrome comes in four variants: type I in patients with normal coronary arteries; type II in patients with inactive pre-existing atheromatous disease; type III in patients with pre-existing coronary artery stenting; type IV in patients with a pre-existing coronary artery bypass. Recently, we came across a case of recurrent type I Kounis syndrome in our clinical practice. The purpose of the paper is to present our case and conduct a review using the Pubmed scientific database about the most relevant cases of recurrent Kounis syndrome. This review shows that recurrent Kounis syndrome is a rare condition and is mostly associated with Kounis syndrome type III. Recurrent Kounis syndrome may be also triggered by vaccination and it could be associated with chronic spontaneous urticaria. In the last condition, therapy is represented by second-generation anti-histamines and corticosteroids, but also by an anti-IgE monoclonal antibody (omalizumab) in the recalcitrant cases. Full article
(This article belongs to the Special Issue Allergic and Eosinophilic Diseases: Diagnosis, Treatment, and Management)

Other

Jump to: Research, Review

7 pages, 753 KiB  
Brief Report
The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) Angioedema
by Magdalena Zajac, Andrzej Bozek and Alicja Grzanka
J. Clin. Med. 2024, 13(2), 477; https://doi.org/10.3390/jcm13020477 - 15 Jan 2024
Viewed by 545
Abstract
Background: Isolated mast cell angioedema (MC-AE) can be divided into allergic and nonallergic (spontaneous) forms. The former is often associated with food, Hymenoptera venoms or drug allergies. This study aimed to evaluate the relationship between the occurrence of atopic diseases and the risk [...] Read more.
Background: Isolated mast cell angioedema (MC-AE) can be divided into allergic and nonallergic (spontaneous) forms. The former is often associated with food, Hymenoptera venoms or drug allergies. This study aimed to evaluate the relationship between the occurrence of atopic diseases and the risk of angioedema. Methods: A retrospective study analyzed 304 patients with confirmed MC-AE and 1066 controls. All were analyzed for allergic asthma (AA), atopic dermatitis (AD) and allergic rhinitis (AR) based on ICD-10 codes. In addition, total IgE and peripheral eosinophilia were calculated. Results: The analyzed atopic diseases were more frequent in the group of patients diagnosed with MC-AE than in the controls: 78 (25.7%) vs. 173 (16.2%) for p < 0.01. Patients diagnosed with AD had a higher risk of MC-AE (hazard ratio (HR) = 1.48,) similar to those diagnosed with AR (HR = 1.51). However, in patients with two or three atopic comorbidities, the risk increased significantly to HR = 2.45 or HR = 4.1, respectively. There was a positive correlation between the serum total IgE concentration or eosinophilia and the risk of angioedema (p < 0.01). Conclusion: Patients with MC-AE had a more frequent occurrence of atopic diseases associated with inhalant allergies. This risk increased in patients with IgE-mediated polymorphic disease. Full article
(This article belongs to the Special Issue Allergic and Eosinophilic Diseases: Diagnosis, Treatment, and Management)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop