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Innovative Surgical Researches: 2nd Edition
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Innovative Surgical Researches: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 2342

Special Issue Editors

Prof. Dr. Vito D'Andrea

E-Mail Website
Guest Editor
Department of Surgery, Sapienza University of Rome, Rome, Italy
Interests: general surgery; abdominal surgery; surgical oncology; minimally invasive surgery; cancer surgery; gastrointestinal surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andrea Mingoli

E-Mail Website
Guest Editor
Department of General Surgery, Università degli Studi di Roma La Sapienza, Rome, Italy
Interests: general surgery; digestive surgery; endocrine surgery; emergency surgery; oncological surgery; vascular surgery; trauma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the 2nd Edition of the Special Issue "Innovative Surgical Research”, which comes as a result of the first edition's (https://www.mdpi.com/journal/jcm/special_issues/Surgical_Researches) success, in which we reported many interesting works in general surgery.

“Innovative Surgical Research: 2nd Edition” is still dedicated to innovative diagnostic and operating technologies used in general surgery, urology and otorynolaryngoiatrics. We welcome original papers and reviews focusing on neoplastic diseases and placing emphasis on pathophysiological conditions induced by surgical intervention. Regarding diseases of surgical interest, issues of basic research, including knowledge of neuroendocrinology, and immune mechanisms will be addressed, as well as new therapeutic strategies and the development of innovative surgical and minimally invasive methodologies.

We welcome research aimed at identifying etiological factors and novel prevention and diagnostic and therapeutic targets through original studies of tumors and their microenvironment. Sampling of human cancer using minimally invasive diagnostics (i.e., liquid biopsies), knowledge on cancer progression, studies of evidence-based risk, predictive biomarkers of early diagnosis, treatment and disease monitoring, and translational research in prevention, diagnostics, and care will be considered.

For this Special Issue, potential topics include, but are not limited to, the following:

  • Minimally invasive surgical treatment;
  • Endoscopic digestive surgery;
  • Endovascular surgery;
  • Minimally invasive urology;
  • Minimally invasive head and neck surgery;
  • Early diagnosis of cancers;
  • Near-infrared/indocyanine green (NIR/ICG) technology imaging;
  • Fluorescence imaging;
  • Surgical robotics;

We are prioritizing high-quality original studies but also welcome well-designed meta-analyses and reviews. We look forward to receiving your contributions.

Prof. Dr. Vito D'Andrea
Prof. Dr. Andrea Mingoli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • general surgery
  • digestive surgery
  • endocrine surgery
  • emergency surgery
  • bariatric surgery
  • breast surgery
  • oncological surgery
  • vascular surgery
  • laparoscopic surgery
  • robotic surgery

Related Special Issue

Published Papers (3 papers)

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Research

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15 pages, 253 KiB  
Article
Sutureless Repair for Open Treatment of Inguinal Hernia: Three Techniques in Comparison
by Enke Baldini, Eleonora Lori, Carola Morini, Luigi Palla, Diego Coletta, Giuseppe M. De Luca, Giorgio Giraudo, Sergio G. Intini, Bruno Perotti, Angelo Sorge, Giampaolo Sozio, Marco Arganini, Elsa Beltrami, Daniele Pironi, Massimo Ranalli, Cecilia Saviano, Alberto Patriti, Sofia Usai, Nicola Vernaccini, Francesco Vittore, Vito D’Andrea, Priscilla Nardi, Salvatore Sorrenti and Piergaspare Palumboadd Show full author list remove Hide full author list
J. Clin. Med. 2024, 13(2), 589; https://doi.org/10.3390/jcm13020589 - 19 Jan 2024
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Abstract
Currently, groin hernia repair is mostly performed with application of mesh prostheses fixed with or without suture. However, views on safety and efficacy of different surgical approaches are still partly discordant. In this multicentre retrospective study, three sutureless procedures, i.e., mesh fixation with [...] Read more.
Currently, groin hernia repair is mostly performed with application of mesh prostheses fixed with or without suture. However, views on safety and efficacy of different surgical approaches are still partly discordant. In this multicentre retrospective study, three sutureless procedures, i.e., mesh fixation with glue, application of self-gripping mesh, and Trabucco’s technique, were compared in 1034 patients with primary unilateral non-complicated inguinal hernia subjected to open anterior surgery. Patient-related features, comorbidities, and drugs potentially affecting the intervention outcomes were also examined. The incidence of postoperative complications, acute and chronic pain, and time until discharge were assessed. A multivariate logistic regression was used to compare the odds ratio of the surgical techniques adjusting for other risk factors. The application of standard/heavy mesh, performed in the Trabucco’s technique, was found to significantly increase the odds ratio of hematomas (p = 0.014) and, most notably, of acute postoperative pain (p < 0.001). Among the clinical parameters, antithrombotic therapy and large hernia size were independent risk factors for hematomas and longer hospital stay, whilst small hernias were an independent predictor of pain. Overall, our findings suggest that the Trabucco’s technique should not be preferred in patients with a large hernia and on antithrombotic therapy. Full article
(This article belongs to the Special Issue Innovative Surgical Researches: 2nd Edition)
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Review

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12 pages, 288 KiB  
Review
Colorectal Cancer: Current Updates and Future Perspectives
by Rosa Marcellinaro, Domenico Spoletini, Michele Grieco, Pasquale Avella, Micaela Cappuccio, Raffaele Troiano, Giorgio Lisi, Giovanni M. Garbarino and Massimo Carlini
J. Clin. Med. 2024, 13(1), 40; https://doi.org/10.3390/jcm13010040 (registering DOI) - 21 Dec 2023
Viewed by 1099
Abstract
Colorectal cancer is a frequent neoplasm in western countries, mainly due to dietary and behavioral factors. Its incidence is growing in developing countries for the westernization of foods and lifestyles. An increased incidence rate is observed in patients under 45 years of age. [...] Read more.
Colorectal cancer is a frequent neoplasm in western countries, mainly due to dietary and behavioral factors. Its incidence is growing in developing countries for the westernization of foods and lifestyles. An increased incidence rate is observed in patients under 45 years of age. In recent years, the mortality for CRC is decreased, but this trend is slowing. The mortality rate is reducing in those countries where prevention and treatments have been implemented. The survival is increased to over 65%. This trend reflects earlier detection of CRC through routine clinical examinations and screening, more accurate staging through advances in imaging, improvements in surgical techniques, and advances in chemotherapy and radiation. The most important predictor of survival is the stage at diagnosis. The screening programs are able to reduce incidence and mortality rates of CRC. The aim of this paper is to provide a comprehensive overview of incidence, mortality, and survival rate for CRC. Full article
(This article belongs to the Special Issue Innovative Surgical Researches: 2nd Edition)

Other

Jump to: Research, Review

14 pages, 1541 KiB  
Systematic Review
Comparative Outcomes of Open Radical Cystectomy vs. Robot-Assisted Approaches with Intracorporeal and Extracorporeal Urinary Diversion: A Meta-Analysis and Network Meta-Analysis of Perioperative and Quality of Life Outcomes
by Rocco Simone Flammia, Leslie Claire Licari, Eugenio Bologna, Riccardo Mastroianni, Flavia Proietti, Gabriele Tuderti, Umberto Anceschi, Aldo Brassetti, Antonio Franco, Cosimo De Nunzio, Riccardo Autorino, Costantino Leonardo and Giuseppe Simone
J. Clin. Med. 2024, 13(8), 2421; https://doi.org/10.3390/jcm13082421 - 21 Apr 2024
Viewed by 333
Abstract
Background: To conduct a comprehensive systematic review and network meta-analysis of RCTs that compare outcomes of robot-assisted radical cystectomy (RARC) with intra- or extracorporeal urinary diversion (ICUD or ECUD) and the standard open approach (oRC). Methods: A systematic review identified RCTs including patients [...] Read more.
Background: To conduct a comprehensive systematic review and network meta-analysis of RCTs that compare outcomes of robot-assisted radical cystectomy (RARC) with intra- or extracorporeal urinary diversion (ICUD or ECUD) and the standard open approach (oRC). Methods: A systematic review identified RCTs including patients aged >18 years with non-metastatic bladder cancer treated with RARC (ICUD or ECUD) vs. oRC and reporting peri- and post-operative outcomes and quality of life (QoL) assessment. Standard and network metanalyses were performed. Results: Data from 1024 patients included in eight RCTs were analyzed. The standard meta-analysis found that RARC had longer OT, lower EBL, and a lower transfusion rate compared to oRC (all p < 0.001). No significant differences in terms of LOS between the ICUD vs. ECUD vs. ORC were recorded. RARC patients demonstrated better scores in fatigue, insomnia, pain, physical functioning, and role functioning—according to QoL assessment—compared to ORC at early follow-up, despite no difference at baselines. Finally, at network metanalysis, ICUD (OR = 0.74, p < 0.001) but not ECUD (OR = 0.92, p < 0.08) yielded a lower rate of high-grade 90-day complications compared to ORC despite longer OT (MD = 89.56, p = 0.0351). Conclusions: RARC represents a safe and feasible option to reduce perioperative bleeding with no definitive impact on LOS compared to ORC. Interestingly, ICUD may reduce the burden of 90-day complications to a greater extent than ECUD. Nonetheless, surgeons should be aware of the extended OT and steep learning curve of ICUD. Finally, RARC may provide some short-term benefits in terms of QoL, but more research is needed to determine its long-term effects. Full article
(This article belongs to the Special Issue Innovative Surgical Researches: 2nd Edition)
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