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Gestational Diabetes: Current Knowledge and Therapeutic Prospects
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Gestational Diabetes: Current Knowledge and Therapeutic Prospects

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 2704

Special Issue Editor

Dr. Francesco Corrado

E-Mail Website
Guest Editor
Department of Obstetrics and Gynaecology, Policlinico Universitario Gazzi, University of Messina, 98124 Messina, Italy
Interests: pregnancy; gestational diabetes; reproductive physiopathology; prenatal diagnostics

Special Issue Information

Dear Colleagues,

Although gestational diabetes is a well known and widely treated topic, the knowledge of the various aspects of this pathology is always enriched with new details. Therefore, deepening the latest developments in the various related fields, such as screening, diagnosis, perinatal outcome, possibilities of prevention and treatment, and follow-up information, is always useful for maintaining an updated knowledge of this pathology.

This Special Issue aims to provide a comprehensive review on this topic by collecting papers from an expert panel of authors.

Dr. Francesco Corrado
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gestational diabetes mellitus
  • diabetes in pregnancy
  • glucose intolerance in pregnancy
  • perinatal outcome
  • follow-up

Published Papers (2 papers)

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Review

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13 pages, 780 KiB  
Review
Antepartum Fetal Surveillance and Optimal Timing of Delivery in Diabetic Women: A Narrative Review
by Alan Braverman-Poyastro, Blanca Vianey Suárez-Rico, Héctor Borboa-Olivares, Salvador Espino y Sosa, Johnatan Torres-Torres, Lidia Arce-Sánchez, Nayeli Martínez-Cruz and Enrique Reyes-Muñoz
J. Clin. Med. 2024, 13(2), 313; https://doi.org/10.3390/jcm13020313 - 05 Jan 2024
Viewed by 1878
Abstract
Antepartum fetal surveillance (AFS) is essential for pregnant women with diabetes to mitigate the risk of stillbirth. However, there is still no universal consensus on the optimal testing method, testing frequency, and delivery timing. This review aims to comprehensively analyze the evidence concerning [...] Read more.
Antepartum fetal surveillance (AFS) is essential for pregnant women with diabetes to mitigate the risk of stillbirth. However, there is still no universal consensus on the optimal testing method, testing frequency, and delivery timing. This review aims to comprehensively analyze the evidence concerning AFS and the most advantageous timing for delivery in both gestational and pregestational diabetes mellitus cases. This review’s methodology involved an extensive literature search encompassing international diabetes guidelines and scientific databases, including PubMed, MEDLINE, Google Scholar, and Scopus. The review process meticulously identified and utilized pertinent articles for analysis. Within the scope of this review, a thorough examination revealed five prominent international guidelines predominantly addressing gestational diabetes. These guidelines discuss the utility and timing of fetal well-being assessments and recommendations for optimal pregnancy resolution timing. However, the scarcity of clinical trials directly focused on this subject led to a reliance on observational studies as the basis for most recommendations. Glucose control, maternal comorbidities, and the medical management received are crucial in making decisions regarding AFS and determining the appropriate delivery timing. Full article
(This article belongs to the Special Issue Gestational Diabetes: Current Knowledge and Therapeutic Prospects)
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15 pages, 561 KiB  
Systematic Review
Early HbA1c Levels as a Predictor of Adverse Obstetric Outcomes: A Systematic Review and Meta-Analysis
by Laura Mañé, Humberto Navarro, Juan Pedro-Botet, Juan José Chillarón, Silvia Ballesta, Antonio Payà, Verónica Amador, Juana Antonia Flores-Le Roux and David Benaiges
J. Clin. Med. 2024, 13(6), 1732; https://doi.org/10.3390/jcm13061732 - 17 Mar 2024
Viewed by 620
Abstract
Background: The objective was to assess the association between early HbA1c levels and pregnancy complications and whether this relationship is affected when HbA1c thresholds are greater than or less than 39 mmol/mol (5.7%). Methods: Electronic searches of the MEDLINE and EMBASE [...] Read more.
Background: The objective was to assess the association between early HbA1c levels and pregnancy complications and whether this relationship is affected when HbA1c thresholds are greater than or less than 39 mmol/mol (5.7%). Methods: Electronic searches of the MEDLINE and EMBASE databases up to October 2022 were conducted. We included retrospective and prospective observational studies. The inclusion criteria were as follows: HbA1c measurements taken at <20 weeks’ gestation, singleton pregnancy, and no pre-existing diabetes mellitus. Results: We assessed the certainty of the evidence with the GRADE system. We determined the proportion of patients in each group who met the criteria for obstetrical outcomes and pooled data into two subgroups according to the HbA1c threshold: <39 mmol/mol or >39 mmol/mol (5.7%). Sixteen studies with a total of 43,627 women were included. An association between elevated early HbA1c levels and pre-eclampsia, large for gestational age (LGA), macrosomia, and preterm delivery (RR 2.02, 95% CI 1.53–2.66; RR 1.38, 95% CI 1.15–1.66; RR 1.40, 95% CI 1.07–1.83; and RR 1.67, 95% CI 1.39–2.0, respectively) was shown, with a moderate–high grade of certainty. According to the subgroup analysis of all studies, LGA, pre-eclampsia, and labour induction were associated with elevated HbA1c levels only in studies using an HbA1c threshold >39 mmol/mol (5.7%). The association between HbA1c levels and premature birth was statistically significant in studies using both higher and lower HbA1c thresholds. Conclusions: Women with high early HbA1c levels below the range of diabetes presented an increased risk of pregnancy complications such as macrosomia, LGA, and pre-eclampsia. An early HbA1c threshold of >39 mmol/mol (5.7%) showed the strongest association with pregnancy complications. Full article
(This article belongs to the Special Issue Gestational Diabetes: Current Knowledge and Therapeutic Prospects)
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