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Reproductive Endocrinology Topics in Children and Adolescents
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Reproductive Endocrinology Topics in Children and Adolescents

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Pediatrics".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 2536

Special Issue Editors

Dr. Charikleia Stefanaki

E-Mail Website
Guest Editor
1. Center for Adolescent Medicine and UNESCO Chair in Adolescent Health Care, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece
2. Unit of Endocrinology, Diabetes and Metabolism, School of Medicine, National and Kapodistrian University of Athens, Aretaieion Hospital, Athens, Greece
Interests: paediatrics; adolescent medicine; metabolism; stress; microbiome
Prof. Dr. George Mastorakos

E-Mail Website
Guest Editor
Unit of Endocrinology, Diabetes and Metabolism, School of Medicine, National and Kapodistrian University of Athens, Aretaieion Hospital, Athens, Greece
Interests: reproductive endocrinology; endocrinology; diabetes; metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reproductive endocrinology in paediatric and adolescent patients covers a broad spectrum of disorders, from birth to early adult life. Reproductive endocrinology is a wide field, embracing areas such as assisted reproduction technologies, reproductive behaviour, gonadal physiology, puberty, endocrine pharmacology, and many other topics of great interest to endocrinologists, gynaecologists, paediatric endocrinologists, adolescent medicine experts, and paediatric as well as adolescent gynaecology experts. This Special Issue aspires to give an overview of hot topics in reproductive endocrinology issues in addition to the latest hot topics, such as transgender health in adolescents, the microbiome, and disorders of adolescent male gonads.

Topics include the following:

  • Primary amenorrhea;
  • Secondary amenorrhea;
  • Prepubertal vaginal bleeding;
  • Abnormal menstrual bleeding;
  • Premature ovarian failure;
  • Polycystic ovary syndrome (PCOS);
  • Functional hypothalamic amenorrhea;
  • Congenital adrenal hyperplasia (CAH);
  • Preservation of fertility in paediatric and adolescent oncology patients;
  • Genetic syndromes: Turner’s, Kallman’s, Perrault’s, Mayer–Rokitansky–Küster–Hauser, and Antley–Bixler’s syndromes;
  • Male hypogonadism in paediatrics and adolescents;
  • Disorders of sex development;
  • Adolescent gynecomastia;
  • Receptor abnormalities and enzyme defects (complete androgen insensitivity syndrome, 5-a reductase deficiency, P450 oxidoreductase deficiency (PORD), and oestrogen resistance);
  • Adolescent contraception;
  • Teen pregnancy issues;
  • Transgender health.

Dr. Charikleia Stefanaki
Prof. Dr. George Mastorakos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive endocrinology
  • adolescents
  • paediatrics
  • male hypogonadism
  • female hypogonadism
  • reproductive metabolism
  • PCOS
  • POF
  • receptor abnormalities
  • menstrual cycle
  • transgender health
  • CAH
  • ovaries
  • gonads
  • hormones
  • sex development
  • amenorrhea
  • oestrogen resistance
  • androgen resistance
  • teen pregnancy
  • oncology
  • preservation of fertility

Published Papers (2 papers)

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Research

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15 pages, 324 KiB  
Article
Hepatokine Profile in Adolescents with Polycystic Ovary Syndrome: A Case–Control Study
by Aikaterini Giannouli, Charikleia Stefanaki, Christos Kouskoutis, Marianna Konidari, Iliana Mani, Konstantina Konidari, Sophia L. Markantonis, Aimilia Mantzou, Spyridon P. Dourakis, Efthymios Deligeoroglou and Flora Bacopoulou
J. Clin. Med. 2023, 12(17), 5744; https://doi.org/10.3390/jcm12175744 - 04 Sep 2023
Cited by 2 | Viewed by 1165
Abstract
The current guidelines suggest routine screening for non-alcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS). Hepatokines seem to be promising surrogate endpoints for the diagnosis and severity of NAFLD. PCOS has its onset in adolescence and its metabolic sequalae [...] Read more.
The current guidelines suggest routine screening for non-alcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS). Hepatokines seem to be promising surrogate endpoints for the diagnosis and severity of NAFLD. PCOS has its onset in adolescence and its metabolic sequalae begin during the same period. There are scarce data on the hepatokine profile of adolescent PCOS patients. This case–control study examined the serum profile of the hepatokines sex hormone-binding globulin (SHBG), selenoprotein P, fibroblast growth factor 21 (FGF21), and fetuin A in a sample of adolescent PCOS patients, and their association to metabolic and hormonal parameters. The selenoprotein P and SHBG serum concentrations were significantly decreased in PCOS patients vs. the controls (median (IQR), 2.47 (0.40) vs. 2.66 (0.36) μg/mL, p = 0.025; mean ± SD, 41.71 ± 19.41 vs. 54.94 ± 22.12 nmol/L, p = 0.011, respectively), whereas selenoprotein P was significantly and positively associated with testosterone (r = 0.325, p = 0.007) and the free androgen index (r = 0.361, p = 0.002). The SHBG demonstrated multiple significant negative correlations with adverse metabolic parameters. Among the PCOS patients, the FGF21 concentrations were significantly higher in those with NAFLD, whereas a 1 pg/mL increase in the FGF21 concentration increased the odds of NAFLD diagnosis by liver ultrasound by 1%, suggesting FGF21 as a potential biomarker for hepatic disease in females with PCOS in adolescence. Fetuin A was the least differentiated hepatokine between the PCOS patients and controls with the least associations with metabolic and hormonal parameters. Full article
(This article belongs to the Special Issue Reproductive Endocrinology Topics in Children and Adolescents)

Review

Jump to: Research

10 pages, 245 KiB  
Review
A Risk of Gonadoblastoma in Familial Swyer Syndrome—A Case Report and Literature Review
by Ewa Rudnicka, Aleksandra Jaroń, Jagoda Kruszewska, Roman Smolarczyk, Krystian Jażdżewski, Paweł Derlatka and Anna Małgorzata Kucharska
J. Clin. Med. 2024, 13(3), 785; https://doi.org/10.3390/jcm13030785 - 30 Jan 2024
Viewed by 1005
Abstract
A complete gonadal dysgenesis (CGD) with 46,XY karyotype is known as the Swyer syndrome and belongs to the group of 46,XY differences of sex development (DSD). The main problem in patients with Swyer syndrome is the delayed puberty and primary amenorrhea. Moreover, intrabdominal [...] Read more.
A complete gonadal dysgenesis (CGD) with 46,XY karyotype is known as the Swyer syndrome and belongs to the group of 46,XY differences of sex development (DSD). The main problem in patients with Swyer syndrome is the delayed puberty and primary amenorrhea. Moreover, intrabdominal dysgenetic gonads in the patient with genetic material of a Y chromosome may conduce to the development of gonadal tumors, such as gonadoblastoma or germinoma. The management of such patients is based on preventive excision of dysgenetic gonads and long-term hormonal replacement therapy. Sporadic cases are considered more common than familial cases. This paper presents two siblings with Swyer syndrome in whom gonadoblastoma was found. A thorough review of familial CGD with 46,XY DSD in the literature from the last 15 years suggests that the risk of gonadal tumors could be increased in familial compared to sporadic cases (66.6% vs. 15–45%, respectively). Full article
(This article belongs to the Special Issue Reproductive Endocrinology Topics in Children and Adolescents)
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