Update in Osteoporosis and Related Bone Metabolic Disease—2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 381

Special Issue Editor


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Guest Editor
Laboratory of Rheumatology, GIGA-Research, CHULiège, ULiège, 4000 Liège, Belgium
Interests: osteoporosis; metabolic bone disease; osteoarthritis; dual X-ray densitometry; high-resolution peripheral quantitative computed tomography
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Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled “Update in Osteoporosis and Related Bone Metabolic Disease—2nd Edition”. This is a new volume, we published six papers in the first volume. For more details, please visit:
https://www.mdpi.com/journal/jcm/special_issues/Osteoporosis_Bone_Metabolic.

Osteoporosis is a common and well-known disease associated with fractures. These fractures lead to pain, disabilities, and incapacitation but are also associated with a higher mortality rate. However, despite this simple and clear assessment, osteoporosis remains an underdiagnosed and, therefore, undertreated disease. Although medical conditions leading to low bone mineral density and fracture risk are widely known to the medical community, screening these patients for osteoporosis is not effective enough. Moreover, even after a fragility fracture, therapeutic prescription is often forgotten.

This Special Issue aims to reduce this treatment gap and focuses on recognizing and screening for osteoporosis, especially after fracture and among patients with medical chronic diseases. Articles on osteoporosis screening, secondary osteoporosis, treatment gap or fracture detection are welcomed, as are any articles helping to better recognize osteoporosis or describing new or alternative methods of osteoporosis diagnosis.

Dr. Olivier Malaise
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoporosis
  • metabolic bone disease
  • screening
  • fracture
  • dual X-ray densitometry

Published Papers (1 paper)

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Review

7 pages, 472 KiB  
Review
Hypophosphatasia Presenting as a Chronic Diffuse Pain Syndrome with Extra-Articular Calcifications
by Florence Lehane, Olivier Malaise, Christian Von Frenckell, Bernard Otto, Elisa Docampo and Clio Ribbens
J. Clin. Med. 2024, 13(8), 2263; https://doi.org/10.3390/jcm13082263 - 13 Apr 2024
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Abstract
Hypophosphatasia is a rare genetic disease characterized by abnormal alkaline phosphatase activity and deficiency of bone and teeth mineralization. Hypophosphatasia is well known in pediatrics with typical presentations in children, but mild forms can also be present in adults and are difficult to [...] Read more.
Hypophosphatasia is a rare genetic disease characterized by abnormal alkaline phosphatase activity and deficiency of bone and teeth mineralization. Hypophosphatasia is well known in pediatrics with typical presentations in children, but mild forms can also be present in adults and are difficult to detect. We present the case of a 50-year-old woman referred for pain management, with a previous diagnosis of fibromyalgia. The association of clinical features (diffuse pain syndrome, early dental loosening, personal history of two fractures with osteoporosis, and family history of osteoporosis) with radiographic (heterotopic calcifications of the yellow and interspinous lumbar ligaments) and biological (low levels of total alkaline phosphatase) indices was suggestive of hypophosphatasia, which was confirmed by genetic analysis. We review and discuss the association between hypophosphatasia, musculoskeletal pain, and calcium pyrophosphate deposition and the importance of raising the diagnosis of adult-onset hypophosphatasia when facing these two rheumatologic entities. Full article
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