Non-aortic Percutaneous Structural Heart Intervention: Ongoing Issues and Challenges

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 2655

Special Issue Editors


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Guest Editor
Sorbonne Université, ACTION Study Group, INSERM UMRS_1166, Institut de cardiologie, Hôpital Pitié Salpêtrière (AP-HP), Paris, France
Interests: antithrombotic therapy; structural heart intervention; coronary intervention
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Sorbonne Université, ACTION Study Group, INSERM UMRS_1166, Institut de cardiologie, Hôpital Pitié Salpêtrière (AP-HP), Paris, France
Interests: antithrombotic therapy; structural heart intervention; coronary intervention
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Considerable expansion of percutaneous heart structural interventions has been witnessed in the last few decades. In our previous Special Issue, we investigated challenges with transcatheter aortic valve replacement. In Part II of this Special Issue, we would like to focus on the other aspects of structural heart interventions, including, but not limited to, patent foramen ovale or atrial septal defect percutaneous closure, transcatheter mitral/tricuspid valve replacement and clipping,  and percutaneous left atrial appendage occlusion. We aim to explore current and future indications and detail the ongoing challenges by providing state-of-the-art reviews and original researches dedicated to each of these interventions.

Dr. Paul Guedeney
Prof. Dr. Jean-Philippe Collet
Guest Editors

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Keywords

  • transcatheter mitral valve replacement
  • mitraclip
  • patent foramen ovale
  • atrial septal defect
  • left atrial appendage
  • transcatheter tricuspid valve replacement
  • triclip
  • edge-to-edge repair

Published Papers (2 papers)

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Review

18 pages, 2691 KiB  
Review
Percutaneous Left Atrial Appendage Occlusion—Current Evidence and Future Directions
by Johannes Rotta detto Loria, Steffen Desch, Janine Pöss, Katharina Kirsch, Holger Thiele and Marcus Sandri
J. Clin. Med. 2023, 12(23), 7292; https://doi.org/10.3390/jcm12237292 - 24 Nov 2023
Viewed by 991
Abstract
Over the past two decades, percutaneous left atrial appendage occlusion (LAAO) has proven to be a viable alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF), in particular in those patients who are at increased risk for stroke [...] Read more.
Over the past two decades, percutaneous left atrial appendage occlusion (LAAO) has proven to be a viable alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF), in particular in those patients who are at increased risk for stroke and bleeding complications. This systematic review provides a comprehensive evaluation of anatomical features, patient selection, procedural planning and execution, complications, medical treatment following the procedure, and contemporary outcome data. Full article
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17 pages, 944 KiB  
Review
Transcatheter Mitral Valve Replacement Using Transcatheter Aortic Valve or Dedicated Devices: Current Evidence and Future Prospects
by Victor Quentin, Jules Mesnier, Clémence Delhomme, Neila Sayah, Paul Guedeney, Olivier Barthélémy, Gaspard Suc and Jean-Philippe Collet
J. Clin. Med. 2023, 12(21), 6712; https://doi.org/10.3390/jcm12216712 - 24 Oct 2023
Viewed by 1306
Abstract
Transcatheter mitral valve replacement (TMVR) is a novel and evolving field dedicated to addressing the therapeutic challenges posed by patients at high surgical risk with mitral valve disease. TMVR can be categorized into two distinct fields based on the type of device and [...] Read more.
Transcatheter mitral valve replacement (TMVR) is a novel and evolving field dedicated to addressing the therapeutic challenges posed by patients at high surgical risk with mitral valve disease. TMVR can be categorized into two distinct fields based on the type of device and its specific indications: TMVR with transcatheter aortic valves (TAV) and TMVR with dedicated devices. Similar to aortic stenosis, TMVR with TAV requires a rigid support structure to secure the valve in place. As a result, it is indicated for patients with failing bioprothesis or surgical rings or mitral valve disease associated with severe mitral annular calcification (MAC), which furnishes the necessary foundation for valve anchoring. While TMVR with TAV has shown promising outcomes in valve-in-valve procedures, its effectiveness remains more contentious in valve-in-ring or valve-in-MAC procedures. Conversely, TMVR with dedicated devices seeks to address native mitral regurgitation, whether accompanied by MAC or not, providing an alternative to Transcatheter Edge-to-Edge Repair (TEER) when TEER is not feasible or expected to yield unsatisfactory results. This emerging field is gradually surmounting technical challenges, including anchoring a valve in a non-calcified annulus and transitioning from the transapical route to the transeptal approach. Numerous devices are presently undergoing clinical trials. This review aims to furnish an overview of the supporting evidence for TMVR using TAV in each specific indication (valve-in-valve, valve-in-ring, valve-in-MAC). Subsequently, we will discuss the anticipated benefits of TMVR with dedicated devices over TEER, summarize the characteristics and clinical results of TMVR systems currently under investigation, and outline future prospects in this field. Full article
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