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State of the Art—Treatment of Skull Base Diseases: Volume II
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State of the Art—Treatment of Skull Base Diseases: Volume II

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 306

Special Issue Editor

Dr. Marco Ferrari

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Guest Editor
Section of Otorhinolaryngology—Head and Neck Surgery, Department of Neurosciences, University of Padua, “Azienda Ospedale Università di Padova”, Padua, Italy
Interests: head and neck oncology; head and neck surgery; skull base diseases; skull base surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skull-based diseases, with their intricate challenges in treatment, demand a nuanced approach that balances therapeutic efficacy with patient well-being. This Special Issue delves into the dynamic landscape of therapies for these complex conditions with a gentle touch, acknowledging the delicate nature of interventions in this critical anatomical region. By synthesizing insights from diverse disciplines including neurosurgery, otolaryngology, and radiation oncology, the issue navigates through a rich tapestry of innovative surgical techniques, state-of-the-art imaging modalities, and targeted adjuvant therapies tailored to specific pathologies. From the exploration of minimally invasive endoscopic approaches to the intricacies of skull base reconstruction, the issue spans a comprehensive spectrum of interventions aimed at optimizing patient outcomes while mitigating morbidity.

Moreover, it is with great pride that we announce the successful publication of Volume 1, which has seen the dissemination of nearly 15 outstanding manuscripts. These contributions, each representing the pinnacle of scholarly achievement in the field, have solidified Volume 1's position as a cornerstone in the literature on skull base diseases. Their depth of insight, methodological rigour, and clinical relevance has not only advanced our understanding of these complex conditions but have also provided tangible benefits to clinicians and patients alike. As we embark on Volume 2, we carry forward the momentum and excellence established by Volume 1, with the collective aim of further enriching the discourse surrounding the treatment of skull-based diseases.

Moreover, it underscores the pivotal role of multidisciplinary collaboration in the holistic management of skull base diseases, underscoring the significance of teamwork in achieving therapeutic success. Through a synthesis of cutting-edge research and clinical expertise, this Special Issue emerges as a beacon, illuminating the path forward for clinicians and researchers alike. Serving as a comprehensive guide, it offers invaluable insights into the current state-of-the-art treatments while charting promising directions for future advancements. Volume 1 of this Special Issue has left an indelible mark, setting a precedent for success, and Volume 2 endeavours to carry forth this legacy of excellence, building upon its foundation to further refine treatment strategies and elevate the standard of care for patients with skull base pathologies.

Link to Volume 1: https://www.mdpi.com/journal/jcm/special_issues/Treatment_of_Skull_Base_Diseases

Dr. Marco Ferrari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skull base
  • cranial base
  • tumor
  • cancer
  • lesion
  • surgery
  • adjuvant
  • neoadjuvant

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Published Papers (1 paper)

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Research

16 pages, 5856 KiB  
Article
Radiological Classification and Management Algorithm of Petrous Apex Cholesterol Granuloma
by Daniele Marchioni, Chiara Alberti, Nicola Bisi and Alessia Rubini
J. Clin. Med. 2024, 13(9), 2505; https://doi.org/10.3390/jcm13092505 - 24 Apr 2024
Viewed by 188
Abstract
Background: Petrous apex cholesterol granulomas (PACGs) are benign inflammatory cystic lesions of the temporal bone. Usually, asymptomatic patients may develop symptoms as the lesions expand. The diagnosis is based on both CT and MRI scans and the management relies on “wait and [...] Read more.
Background: Petrous apex cholesterol granulomas (PACGs) are benign inflammatory cystic lesions of the temporal bone. Usually, asymptomatic patients may develop symptoms as the lesions expand. The diagnosis is based on both CT and MRI scans and the management relies on “wait and scan” or surgery. This paper aims at evaluating surgical outcomes and proposing a CT-based classification and a management algorithm. Methods: Patients with PACGs who were surgically treated between 2014 and 2024 were included. Symptoms, imaging, approach type and complications were considered. CT scans were classified as Type A (preserved apex cellularity), Type B (erosion of the apex cellularity), and Type C (involvement of the noble structures bone boundaries). The possible connection of the lesion with the infracochlear, perilabyrinthine and sphenoidal cellularity was assessed. Results: Nineteen patients with symptoms like diplopia, headache and sensorineural hearing loss were included. According to our classification, 1/19 patients was Type A, 4/19 were Type B and 14/19 were Type C. Five patients underwent a total resection, seven a subtotal and seven a surgical drainage. Only two complications were recorded, and 17/19 patients showed symptom regression and stability during follow-up. Conclusions: While the management of PACGs is still controversial, according to our classification and surgical outcomes, Type A, being mostly asymptomatic, should be managed with “wait and scan”, Type B should undergo surgery when symptoms are present, while Type C should always undergo surgery because of their invasiveness and potential complications. When possible, a drainage should be attempted; otherwise, a surgical resection is chosen, and its completeness depends on the preoperative general and hearing status. Full article
(This article belongs to the Special Issue State of the Art—Treatment of Skull Base Diseases: Volume II)
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