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Diagnosing Pancreatic Cancer: Imaging Scan and Endoscopic Ultrasound
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Diagnosing Pancreatic Cancer: Imaging Scan and Endoscopic Ultrasound

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1504

Special Issue Editors

Dr. Sumant Inamdar

E-Mail Website
Guest Editor
Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR 72205, USA
Interests: artificial intelligence; interventional EUS
Dr. Ioannis Anastasiou

E-Mail Website
Guest Editor
Gastroenterology Clinic, University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas, AR 72205, USA
Interests: pancreatitis diagnosis and treatment
Dr. Jayanta Samanta

E-Mail Website
Guest Editor
Postgraduate Institute of Medical Education & Research, Chandigarh, Chandigarh, India
Interests: pancreatic cancer; acute and chronic pancreatitis

Special Issue Information

Dear Colleagues,

Pancreatic adenocarcinoma has one of the gravest prognoses among all cancers. The early diagnosis of pancreatic cancer remains essential to improve the survival rates in these patients. With the recent advances in technology, the ability to diagnose pancreatic carcinoma has improved compared to a decade ago.  The evolution of diagnostic techniques such as contrast-enhanced Doppler ultrasound (US), helical computed tomography (CT), enhanced magnetic resonance imaging (MRI), and endoscopic US (EUS) has improved the early diagnosis of this type of cancer. Despite these improvements in technology and diagnostic modalities, the survival for pancreatic cancer remains disappointing. The recent advances in endoscopic ultrasound, increased application of artificial intelligence, and better diagnostic techniques such as fine needle biopsy have shown promise in the early diagnosis of this disease.

Since improving outcomes of pancreatic cancer is an area of urgent need, this Special Issue aims to summarize the established diagnostics modalities and provide readers with a deeper understanding of emerging technologies in pancreatic cancer diagnosis. It is our great privilege to invite you to contribute to this Special Issue. 

Dr. Sumant Inamdar
Dr. Ioannis Anastasiou
Dr. Jayanta Samanta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pancreatic cancer
  • endoscopic ultrasound (EUS)
  • artificial intelligence
  • staging and biopsy (FNA / FNB)
  • pancreatitis

Published Papers (2 papers)

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12 pages, 2334 KiB  
Article
CT Attenuation of Hepatic Pancreatic Cancer Metastases Correlates with Prognostically Detrimental Metastatic Necrosis
by Stefan Reischl, Sebastian Ziegelmayer, Markus Graf, Joshua Gawlitza, Andreas Philipp Sauter, Manuel Steinhardt, Marie-Christin Weber, Philipp-Alexander Neumann, Marcus Richard Makowski, Fabian Karl Lohöfer, Carolin Mogler and Rickmer Früdd Braren
J. Clin. Med. 2023, 12(23), 7319; https://doi.org/10.3390/jcm12237319 - 26 Nov 2023
Viewed by 739
Abstract
Percutaneous CT-guided biopsy is a frequently performed procedure for the confirmation and molecular workup of hepatic metastases of pancreatic ductal adenocarcinoma (PDAC). Tumor necrosis of primary PDAC has shown a negative prognostic impact in recent studies. This study aims to examine predictability in [...] Read more.
Percutaneous CT-guided biopsy is a frequently performed procedure for the confirmation and molecular workup of hepatic metastases of pancreatic ductal adenocarcinoma (PDAC). Tumor necrosis of primary PDAC has shown a negative prognostic impact in recent studies. This study aims to examine predictability in CT scans and the prognostic impact of necrosis in hepatic metastases of PDAC. In this tertiary-center retrospective cohort study, we included 36 patients with hepatic metastases of PDAC who underwent CT-guided hepatic biopsies. Normalized attenuation of the biopsied metastasis was determined in venous phase contrast-enhanced planning scans obtained prior to biopsy by automatic, threshold-based 3D segmentation and manual, blinded 2D segmentation. A board-certified pathologist specialized in hepatic pathology histologically quantified the tumor necrosis and cellularity of the biopsy cylinders. We found a significant inverse-linear correlation between normalized attenuation and the fraction of necrosis (Pearson’s r = 0.51, p < 0.001 for automatic 3D segmentation or Pearson’s r = 0.52, p < 0.001 for manual 2D segmentation), whereas no correlation was found with tumor cellularity. Additionally, we discovered that patients with a fraction of necrosis ≥ 20% in metastases had a significantly shorter overall survival (p < 0.035). In summary, tumor necrosis of PDAC metastases can be estimated from contrast-enhanced CT scans, which could help to improve biopsy sample pattern planning. In addition, liver metastatic necrosis may serve as a prognostic biomarker in PDAC. Full article
(This article belongs to the Special Issue Diagnosing Pancreatic Cancer: Imaging Scan and Endoscopic Ultrasound)
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Review

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21 pages, 5800 KiB  
Review
Basic Principles and Role of Endoscopic Ultrasound in Diagnosis and Differentiation of Pancreatic Cancer from Other Pancreatic Lesions: A Comprehensive Review of Endoscopic Ultrasound for Pancreatic Cancer
by Dushyant Singh Dahiya, Yash R. Shah, Hassam Ali, Saurabh Chandan, Manesh Kumar Gangwani, Andrew Canakis, Daryl Ramai, Umar Hayat, Bhanu Siva Mohan Pinnam, Amna Iqbal, Sheza Malik, Sahib Singh, Fouad Jaber, Saqr Alsakarneh, Islam Mohamed, Meer Akbar Ali, Mohammad Al-Haddad and Sumant Inamdar
J. Clin. Med. 2024, 13(9), 2599; https://doi.org/10.3390/jcm13092599 - 28 Apr 2024
Viewed by 451
Abstract
Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Pancreatic lesions consist of both neoplastic and non-neoplastic lesions and often pose a diagnostic and therapeutic challenge due to similar clinical and radiological features. In recent years, pancreatic lesions have been [...] Read more.
Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Pancreatic lesions consist of both neoplastic and non-neoplastic lesions and often pose a diagnostic and therapeutic challenge due to similar clinical and radiological features. In recent years, pancreatic lesions have been discovered more frequently as incidental findings due to the increased utilization and widespread availability of abdominal cross-sectional imaging. Therefore, it becomes imperative to establish an early and appropriate diagnosis with meticulous differentiation in an attempt to balance unnecessary treatment of benign pancreatic lesions and missing the opportunity for early intervention in malignant lesions. Endoscopic ultrasound (EUS) has become an important diagnostic modality for the identification and risk stratification of pancreatic lesions due to its ability to provide detailed imaging and acquisition of tissue samples for analysis with the help of fine-needle aspiration/biopsy. The recent development of EUS-based technology, including contrast-enhanced endoscopic ultrasound, real-time elastography–endoscopic ultrasound, miniature probe ultrasound, confocal laser endomicroscopy, and the application of artificial intelligence has significantly augmented the diagnostic accuracy of EUS as it enables better evaluation of the number, location, dimension, wall thickness, and contents of these lesions. This article provides a comprehensive overview of the role of the different types of EUS available for the diagnosis and differentiation of pancreatic cancer from other pancreatic lesions while discussing their key strengths and important limitations. Full article
(This article belongs to the Special Issue Diagnosing Pancreatic Cancer: Imaging Scan and Endoscopic Ultrasound)
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