Dear Colleagues,

Coronary artery disease (CAD) remains one of the leading causes of death worldwide; however, the past two decades have witnessed tremendous progress in the diagnosis and clinical and surgical treatment of severe CAD and ischemic cardiomyopathy. Computed tomography and magnetic resonance angiography are now established modalities for both anatomic and functional evaluation, alongside traditional testing such as echocardiography and left heart catheterization. The integration of modern imaging techniques with artificial intelligence appears imminent. Moreover, recent guidelines have more clearly defined the roles of both percutaneous therapies (PCI) and coronary artery bypass surgery (CABG) in the treatment of coronary artery disease. Even so, the increasing complexity of severe CAD cases nowadays demands a multidisciplinary approach and, as such, patients may require proper medical or mechanical optimization soon after diagnosis.

Additionally, ischemic heart disease has a significant impact on valvular function, with ischemic mitral and tricuspid regurgitation being a frequent complication of ventricular pathologic remodeling. Thankfully, significant advancements have been made in this field as well, with new evidence on repair versus replacement techniques, as well as transcatheter strategies to restore proper valvular function.

We are therefore pleased to introduce this fascinating editorial initiative titled “Clinical Advances in Ischemic Heart Diseases”, and invite you to submit your original contributions or critical reviews of the existing literature to this Special Issue.

Our goal is to provide our readers with access to rigorously, peer-reviewed content on several aspects of coronary artery disease, including modern imaging, mechanical support of complex ischemic cardiomyopathy, modern revascularization techniques (hybrid, minimally invasive, and robotic), and treatment of ischemic valvulopathies, with ongoing advancements emerging in the foreseeable future.

Dr. Stefano Schena
Guest Editor

Dr. Andrea Amabile
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• multidisciplinary approach
• modern imaging
• myocardial pre-habilitation
• revascularization in severe ischemic cardiomyopathy
• guidelines
• complex PCI
• hybrid treatment
• minimally invasive surgery