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Cardiovascular Remodeling in Metabolic Disorders
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Cardiovascular Remodeling in Metabolic Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 5703

Special Issue Editor

Dr. Elena Dozio

E-Mail Website
Guest Editor
Affiliation: Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy
Interests: obesity; metabolic disorders; biomarkers of cardiovascular diseases; advanced glycation end products

Special Issue Information

Dear Colleagues,

Cardiovascular remodeling is the response of specific cardiovascular cells (cardiomyocytes, endothelial, smooth muscle cells) as well as interstitial cells to different metabolic, hemodynamic, and inflammatory stimuli. Although the process is initially compensatory and functional, when damaging stimuli become chronic, it progresses to structural alterations that manifest clinically as change in size, mass, geometry, and functions of the heart and vessels.

Obesity is often associated with a clustering of cardiovascular risk factors that includes dyslipidemia, diabetes mellitus, inflammation, and hypertension. Alone or in association, these disorders typically predispose to an increased heart rate and stroke volume, which may lead to compensatory left ventricular remodeling, non-ischemic dilated cardiomyopathy, fibrosis, and apoptosis.

Despite novel therapeutic options, the prognosis of the affected patients remains poor. Therefore, understanding novel disease mechanisms, identifying disease biomarkers, and implementing imaging diagnostic tools can lead to early diagnosis and new therapeutic options for these patients.

This Special Issue entitled “Cardiovascular Remodeling in Metabolic Disorders” is open to basic, clinical, and translational original studies and review articles focused on exploring molecular mechanisms, diagnostic and prognostic tools, as well as new therapeutic approaches to improve the management of cardiovascular remodeling and clinical outcome of patients suffering from metabolic disorders such as obesity, diabetes mellitus, and dyslipidemia.

Dr. Elena Dozio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cardiac and vascular remodeling
  • Cardiomyopathy
  • Fibrosis
  • Obesity
  • Diabetes
  • Dyslipidemia
  • Disease biomarkers
  • Diagnostic imaging
  • Therapies
  • Prognosis
  • Disease mechanisms

Published Papers (2 papers)

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Research

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13 pages, 443 KiB  
Article
Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study
by Mirko Parasiliti-Caprino, Chiara Obert, Chiara Lopez, Martina Bollati, Fabio Bioletto, Chiara Bima, Filippo Egalini, Alessandro Maria Berton, Nunzia Prencipe, Fabio Settanni, Valentina Gasco, Giulio Mengozzi, Ezio Ghigo and Mauro Maccario
J. Clin. Med. 2021, 10(9), 1967; https://doi.org/10.3390/jcm10091967 - 04 May 2021
Cited by 4 | Viewed by 1959
Abstract
No research has explored the role of catecholamine metabolites in the stratification of cardiovascular risk. We aimed to evaluate the relationship between urine metanephrines and cardiometabolic risk/complications. In this retrospective cross-sectional study, we collected the data of 1374 patients submitted to the evaluation [...] Read more.
No research has explored the role of catecholamine metabolites in the stratification of cardiovascular risk. We aimed to evaluate the relationship between urine metanephrines and cardiometabolic risk/complications. In this retrospective cross-sectional study, we collected the data of 1374 patients submitted to the evaluation of urine metanephrines at the City of Health and Science University Hospital of Turin between 2007 and 2015, mainly for investigating the suspicion of secondary hypertension or the secretion of an adrenal lesion. The univariate analysis showed associations between metanephrines and cardiometabolic variables/parameters, particularly considering noradrenaline metabolite. At univariate regression, normetanephrine was associated with hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.11–1.25; p < 0.001) and metabolic syndrome (OR = 1.11, 95% CI 1.03–1.20; p = 0.004), while metanephrine was associated with hypertensive cardiomyopathy (OR = 1.23, 95% CI 1.06–1.43; p = 0.006) and microalbuminuria (OR = 1.30, 95% CI 1.03–1.60; p = 0.018). At multivariate regression, considering all major cardiovascular risk factors as possible confounders, normetanephrine retained a significant association with hypertensive cardiomyopathy (OR = 1.14, 95% CI 1.07–1.22; p < 0.001) and metabolic syndrome (OR = 1.10, 95% CI 1.02–1.19; p = 0.017). Moreover, metanephrine retained a significant association with the presence of hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.01–1.41; p = 0.049) and microalbuminuria (OR = 1.34, 95% CI 1.03–1.69; p = 0.019). The study showed a strong relationship between metanephrines and cardiovascular complications/metabolic alterations. Individuals with high levels of these indirect markers of sympathetic activity should be carefully monitored, and they may benefit from an aggressive treatment to reduce the cardiometabolic risk. Full article
(This article belongs to the Special Issue Cardiovascular Remodeling in Metabolic Disorders)
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Review

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25 pages, 999 KiB  
Review
Glycation and Glycosylation in Cardiovascular Remodeling: Focus on Advanced Glycation End Products and O-Linked Glycosylations as Glucose-Related Pathogenetic Factors and Disease Markers
by Elena Dozio, Luca Massaccesi and Massimiliano Marco Corsi Romanelli
J. Clin. Med. 2021, 10(20), 4792; https://doi.org/10.3390/jcm10204792 - 19 Oct 2021
Cited by 14 | Viewed by 2945
Abstract
Glycation and glycosylation are non-enzymatic and enzymatic reactions, respectively, of glucose, glucose metabolites, and other reducing sugars with different substrates, such as proteins, lipids, and nucleic acids. Increased availability of glucose is a recognized risk factor for the onset and progression of diabetes-mellitus-associated [...] Read more.
Glycation and glycosylation are non-enzymatic and enzymatic reactions, respectively, of glucose, glucose metabolites, and other reducing sugars with different substrates, such as proteins, lipids, and nucleic acids. Increased availability of glucose is a recognized risk factor for the onset and progression of diabetes-mellitus-associated disorders, among which cardiovascular diseases have a great impact on patient mortality. Both advanced glycation end products, the result of non-enzymatic glycation of substrates, and O-linked-N-Acetylglucosaminylation, a glycosylation reaction that is controlled by O-N-AcetylGlucosamine (GlcNAc) transferase (OGT) and O-GlcNAcase (OGA), have been shown to play a role in cardiovascular remodeling. In this review, we aim (1) to summarize the most recent data regarding the role of glycation and O-linked-N-Acetylglucosaminylation as glucose-related pathogenetic factors and disease markers in cardiovascular remodeling, and (2) to discuss potential common mechanisms linking these pathways to the dysregulation and/or loss of function of different biomolecules involved in this field. Full article
(This article belongs to the Special Issue Cardiovascular Remodeling in Metabolic Disorders)
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