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Diagnosis and Treatment of Ischaemic Heart Disease
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Diagnosis and Treatment of Ischaemic Heart Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 3988

Special Issue Editors

Prof. Dr. Manuel Martínez-Sellés

E-Mail Website
Guest Editor
1. Cardiology Department, Hospital General Universitario Gregorio Marañón, Calle Doctor Esquerdo, 16, 28007 Madrid, Spain
2. Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain
Interests: coronary artery disease; heart failure; heart transplant; endocarditis; aortic stenosis; sex influence in cardiovascular conditions
Special Issues, Collections and Topics in MDPI journals
Dr. Albert Ariza-Sole

E-Mail Website
Guest Editor
1. Cardiology Department, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
2. Bioheart Grup de Malalties Cardiovasculars, Institut d’Investigació Biomèdica de Bellvitge—IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Interests: Cardiovascular disease; atrial fibrillation; frailty; elderly; inflammation; residual risk; anticoagulation; antiplatelet; ACS; CCS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ischemic heart disease, or coronary artery disease, is the leading cause of death and disability worldwide. Moreover, its importance is expected to increase in the coming years, due to population aging, increasing hypertension in developing countries, and the global growth in obesity. This Special Issue focus on the recent advances on the management of ischemic heart disease and the expected improvements in the diagnosis and treatment of these patients. We aim to include all diagnostic and treatment modalities already available, and future innovations from a broad perspective including clinical medicine, percutaneous interventions, biotechnology, artificial intelligence, tissue engineering, stem cells, nanotechnology, surgery and robotic surgery, 3-D printing, among others.

Prof. Dr. Manuel Martínez-Sellés
Dr. Albert Ariza-Sole
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ischemic heart disease
  • coronary artery disease
  • management
  • treatment
  • diagnosis
  • advances

Published Papers (3 papers)

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10 pages, 616 KiB  
Article
Coronary Artery Disease and Prognosis of Heart Failure with Reduced Ejection Fraction
by Lourdes Vicent, Jesús Álvarez-García, Rafael Vazquez-Garcia, José R. González-Juanatey, Miguel Rivera, Javier Segovia, Domingo Pascual-Figal, Ramón Bover, Fernando Worner, Francisco Fernández-Avilés, Albert Ariza-Sole and Manuel Martínez-Sellés
J. Clin. Med. 2023, 12(8), 3028; https://doi.org/10.3390/jcm12083028 - 21 Apr 2023
Viewed by 1326
Abstract
Our aim was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. From a prospective multicenter registry that included 1831 patients hospitalized due to heart failure, 583 had a left ventricular [...] Read more.
Our aim was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. From a prospective multicenter registry that included 1831 patients hospitalized due to heart failure, 583 had a left ventricular ejection fraction of <40%. In total, 266 patients (45.6%) had coronary artery disease as main etiology and 137 (23.5%) had idiopathic dilated cardiomyopathy (DCM), and they are the focus of this study. Significant differences were found in Charlson index (CAD 4.4 ± 2.8, idiopathic DCM 2.9 ± 2.4, p < 0.001), and in the number of previous hospitalizations (1.1 ± 1, 0.8 ± 1.2, respectively, p = 0.015). One-year mortality was similar in the two groups: idiopathic DCM (hazard ratio [HR] = 1), CAD (HR 1.50; 95% CI 0.83–2.70, p = 0.182). Mortality/readmissions were also comparable: CAD (HR 0.96; 95% CI 0.64–1.41, p = 0.81). Patients with idiopathic DCM had a higher probability of receiving a heart transplant than those with CAD (HR 4.6; 95% CI 1.4–13.4, p = 0.012). The prognosis of HFrEF is similar in patients with CAD etiology and in those with idiopathic DCM. Patients with idiopathic DCM were more prone to receive heart transplant. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Ischaemic Heart Disease)
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7 pages, 770 KiB  
Brief Report
The Value of Exercise Electrocardiography in Outpatients with Stable Chest Pain and Low Pre-Test Probability of Significant Coronary Artery Disease
by Pontus Thorild and Georgios Mourtzinis
J. Clin. Med. 2023, 12(14), 4670; https://doi.org/10.3390/jcm12144670 - 14 Jul 2023
Cited by 1 | Viewed by 1090
Abstract
The role of exercise electrocardiography (ECG) in the investigation of stable chest pain has been questioned. The American Heart Association guidelines suggest the use of exercise ECG in patients with stable chest pain and low pre-test probability (PTP) of significant coronary artery disease, [...] Read more.
The role of exercise electrocardiography (ECG) in the investigation of stable chest pain has been questioned. The American Heart Association guidelines suggest the use of exercise ECG in patients with stable chest pain and low pre-test probability (PTP) of significant coronary artery disease, while the European Society of Cardiology Guidelines does not. This retrospective observational study aimed to assess the usefulness of exercise ECG in the low-PTP population with stable chest pain. We reviewed the medical records for all outpatient exercise ECGs conducted because of stable chest pain at the Department of Medicine and Emergency, Sahlgrenska University Hospital, Mölndal, Sweden, during 2016–2018. The identified patients were categorized in low-, intermediate-, or high-risk pre-test probability of significant coronary artery disease. All low-PTP patients were followed for one year post investigation for the incidence of acute coronary syndrome and all-cause mortality. Thus, 505 patients (mean age 60 years, 56% women) with low PTP were included in the study. Only four patients (0.6%) experienced incident myocardial infarction (three patients) or all-cause mortality (one patient). The negative predictive value of exercise ECG was 99.7%, and the positive predictive value was 28.6%. In this low-PTP population, exercise ECG yields a good negative predictive value and a poor positive predictive value. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Ischaemic Heart Disease)
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8 pages, 1413 KiB  
Brief Report
Off-Hours versus Regular-Hours Implantation of Peripheral Venoarterial Extracorporeal Membrane Oxygenation in Patients with Cardiogenic Shock
by Roberto Gómez-Sánchez, Jorge García-Carreño, Jorge Martínez-Solano, Iago Sousa-Casasnovas, Miriam Juárez-Fernández, Carolina Devesa-Cordero, Ricardo Sanz-Ruiz, Enrique Gutiérrez-Ibañes, Jaime Elízaga, Francisco Fernández-Avilés and Manuel Martínez-Sellés
J. Clin. Med. 2023, 12(5), 1875; https://doi.org/10.3390/jcm12051875 - 27 Feb 2023
Cited by 7 | Viewed by 1115
Abstract
Background. The “weekend effect” has been associated with worse clinical outcomes. Our aim was to compare off-hours vs. regular-hours peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) in cardiogenic shock patients. Methods. We analyzed in-hospital and 90-day mortality among 147 consecutive patients treated with percutaneous [...] Read more.
Background. The “weekend effect” has been associated with worse clinical outcomes. Our aim was to compare off-hours vs. regular-hours peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) in cardiogenic shock patients. Methods. We analyzed in-hospital and 90-day mortality among 147 consecutive patients treated with percutaneous VA-ECMO for medical reasons between July 1, 2013, and September 30, 2022, during regular-hours (weekdays 8:00 a.m.–10:00 p.m.) and off-hours (weekdays 10:01 p.m.–7:59 a.m., weekends, and holidays). Results. The median patient age was 56 years (interquartile range [IQR] 49–64 years) and 112 (72.6%) were men. The median lactate level was 9.6 mmol/L (IQR 6.2–14.8 mmol/L) and 136 patients (92.5%) had a Society for Cardiovascular Angiography and Interventions (SCAI) stage D or E. Cannulation was performed off-hours in 67 patients (45.6%). In-hospital mortality was similar in off-hours and regular hours (55.2% vs. 56.3%, p = 0.901), as was the 90-day mortality (58.2% vs. 57.5%, p = 0.963), length of hospital stay (31 days [IQR 16–65.8 days] vs. 32 days [IQR 18–63 days], p = 0.979), and VA-ECMO related complications (77.6% vs. 70.0%, p = 0.305). Conclusions. Off-hours and regular-hours percutaneous VA-ECMO implantation in cardiogenic shock of medical cause have similar results. Our results support well-designed 24/7 VA-ECMO implantation programs for cardiogenic shock patients. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Ischaemic Heart Disease)
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