Advances in Management of Bladder Cancer
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 15110
Special Issue Editor
Interests: urologic oncology; bladder cancer; bladder cancer diagnosis; endoscopic surgery; oncological surgery; reconstructive surgery; radical cystectomy; orthotopic neobladder
Special Issue Information
Dear Colleagues,
Bladder cancer incidence is increasing worldwide. At present, 75% of cases are nonmuscle-invasive bladder cancer (NMIBC) and the rest are muscle-invasive (MIBC), which can also be a progression of the first kind. For this reason, the high prevalence in the population makes bladder cancer an important economic burden for health systems.
New advancements are required in the diagnostic setting in order to increase early diagnosis and to reduce the number of invasive procedures: Recent identification of target and potential biomarkers based on genomic sequencing analyses will be useful, also for predicting the response of novel therapeutic strategies.
High-risk NMIBC represents a clinical challenge, where gold standard treatment with BCG could fail with recurrence up to 55% and progression up to 20%. A better molecular characterization of the disease is required to define tailored protocols and to introduce new targeted therapies for NMIBC and also for MIBC. For the latter, new surgical techniques and different peri-operative protocols testing the role of PD-1/PD-L1 immune checkpoint inhibitors to combine systemic chemo-immunotherapy are under investigation with the aim of improving prognosis and reducing the impact of radical cystectomy on quality of life, moving forward personalized treatments.
This Special Issue will focus on improvements and criticisms regarding new advances in bladder cancer management.
Prof. Marco Racioppi
Guest Editor
Manuscript Submission Information
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Keywords
- Bladder cancer
- Diagnosis
- Non-urothelial bladder cancer
- Biomarkers
- BCG
- Endoscopic resection
- Istopathology
- Radical cystectomy
- Chemo-Immunotherapy
- Targeted therapy