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Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II
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Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1778

Special Issue Editor

Prof. Dr. Izumi Asahina

E-Mail Website
Guest Editor
Department of Dentistry and Oral Surgery, Juntendo Hospital, 3-1-3 Hongo, Bunkyo‑ku, Tokyo 113‑8421, Japan
Interests: regenerative dentistry; bone tissue engineering; stem cell therapy; gene-activated matrix; implant dentistry; orthognathic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

An understanding of a wide range of bone regeneration, from periodontal defects to jawbone deficiency, is required in the daily practice of dentistry and oral and maxillofacial surgery. In particular, demands for bone regeneration are increasing due to the advancement of aging in our society. Autogenous bone grafts are still widely used as the gold standard because of their superior osteogenecity, though it has disadvantages such as limited availability and donor-site morbidity. However, recent advancements in material sciences and stem cell biology enable us to develop new strategies to regenerate bone deficiencies in the oral and maxillofacial regions. Thus, many clinical studies using new biomaterials, biological molecules, and/or stem cells have been conducted.

This Special Issue is intended to provide an overview of the recent advances in bone regeneration in dentistry and oral and maxillofacial surgery, and to give readers an idea of the strategies to standardize bone regeneration in the next era. The first part of this Special Issue has been successfully published. Now, we plan to publish a second part in response to the interests both from readers and authors.

On behalf of the Journal of Clinical Medicine, you are cordially invited to contribute an article to the Special Issue, “Bone Regeneration in Dentistry and Oral and Maxillofacial Surgery: Part II.” Research articles and reviews are welcome.

Prof. Dr. Izumi Asahina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alveolar bone regeneration
  • jawbone reconstruction
  • clinical trial
  • biomaterials
  • tissue engineering
  • stem cells

Published Papers (2 papers)

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Research

10 pages, 1501 KiB  
Article
A Prospective Study of the Assessment of the Efficacy of a Biodegradable Poly(l-lactic acid/ε-caprolactone) Membrane for Guided Bone Regeneration
by Rena Shido, Seigo Ohba, Risa Tominaga, Yoshinori Sumita and Izumi Asahina
J. Clin. Med. 2023, 12(18), 5994; https://doi.org/10.3390/jcm12185994 - 15 Sep 2023
Viewed by 705
Abstract
Biodegradable guided bone regeneration (GBR) membranes consist primarily of collagen and aliphatic polyesters. This study assessed the comparative efficacy of a poly(l-lactic-caprolactone) [P(LA/CL)] membrane versus that of a collagen membrane in GBR. Patients requiring GBR simultaneously or before dental implant placement [...] Read more.
Biodegradable guided bone regeneration (GBR) membranes consist primarily of collagen and aliphatic polyesters. This study assessed the comparative efficacy of a poly(l-lactic-caprolactone) [P(LA/CL)] membrane versus that of a collagen membrane in GBR. Patients requiring GBR simultaneously or before dental implant placement in edentulous regions were randomly assigned to one of two membranes. Within each membrane, they were subdivided into 3 groups: dental implants were placed simultaneously with GBR in groups A and B, and 180 days post-GBR in group C. The augmented bone width was measured at 1, 3, and 6 mm from the implant’s neck (groups A and B) or the reference line (group C), utilizing cone-beam computed tomography images, immediately and 150 days post-surgery. A histological study was performed to evaluate bone formation in group C. No adverse events were observed. In the collagen group, the absorbed ratios of the augmented bone were 40.9 ± 36.7%, 29.4 ± 30.1%, and 11.1 ± 22.0% at 1, 3, and 6 mm, respectively; the ratio at 6 mm was significantly lower than that at 1 mm (p = 0.0442). In the P(LA/CL) group, those were 26.2 ± 27.3%, 17.1 ± 19.7%, and 13.3 ± 16.4% at 1, 3, and 6 mm, respectively, with no significant difference at each point. No significant inter-membrane differences were observed. The bone augmentation potential of the P(LA/CL) membrane matched that of the collagen membrane. P(LA/CL) could be used as a safe and effective membrane in GBR. Full article
(This article belongs to the Special Issue Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II)
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11 pages, 2880 KiB  
Article
Biomolecular Mechanisms and Case Series Study of Socket Preservation with Tooth Grafts
by Elio Minetti, Gianna Dipalma, Andrea Palermo, Assunta Patano, Alessio Danilo Inchingolo, Angelo Michele Inchingolo and Francesco Inchingolo
J. Clin. Med. 2023, 12(17), 5611; https://doi.org/10.3390/jcm12175611 - 28 Aug 2023
Cited by 2 | Viewed by 683
Abstract
The purpose of this research was to assess the effectiveness of an innovative medical device capable of extracting tooth graft materials directly from the patient’s own teeth. Twenty consecutive tooth grafting procedures were conducted, with an average follow-up period of 18 months. Methods: [...] Read more.
The purpose of this research was to assess the effectiveness of an innovative medical device capable of extracting tooth graft materials directly from the patient’s own teeth. Twenty consecutive tooth grafting procedures were conducted, with an average follow-up period of 18 months. Methods: Twenty patients requiring tooth extraction underwent socket preservation utilizing the extracted tooth as the grafting material. Results: After a 4-month healing period, the defects were significantly filled with newly formed hard tissue. Subsequently, bone biopsies were performed during dental implant placement to evaluate histological outcomes. The tissue exhibited a similar density to medium-density bone, displaying a homogeneous and uniform appearance without any visible signs of inflammation. The post-operative healing phase was free from infective complications or indications of graft particles within the regenerated bone structure. The histomorphometric analyses revealed the following results: bone total volume, BV% 52.6 ± 13.09, vital bone VB% 40.39 ± 15.86, residual graft % 12.20 ± 12.34. Conclusion: The study demonstrated positive bony healing in guided regenerative surgery procedures using autologous tooth grafts. However, further research with an extended follow-up period is necessary to thoroughly assess the potential of demineralized dentin autografts. Full article
(This article belongs to the Special Issue Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II)
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