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Novel Biomarkers for the Diagnosis, Prognosis and Management of Acute...
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Novel Biomarkers for the Diagnosis, Prognosis and Management of Acute Kidney Injury—Part II

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 6605

Special Issue Editor

Prof. Dr. Yacov Shacham

E-Mail Website
Guest Editor
Cardiology Intensive Care Unit, Tel-Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel
Interests: primary coronary intervention; heart failure; cardiogenic shock; cardio-renal syndromes; reperfusion injury
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In January 2021, we launched a Special Issue on the topic of “Novel Biomarkers for the Diagnosis, Prognosis, and Management of Acute Kidney Injury—Part I” (https://www.mdpi.com/journal/jcm/special_issues/Biomarkers_Kidney). In this issue, a large number of papers were published on the utilization of biomarkers in clinical practice and various patient populations, including chronic kidney disease, acute coronary syndromes, cardiac arrhythmias, and tubular damage related to various medications. These studies highlighted the central role of biomarkers of renal damage in the early identification of injury, stratification according to injury severity, etiologic specificity for injury, and prognostic information.

Given the enormous success of Part I, I believe that it is time to move forward with Special Issue Part II, collecting additional insights into the importance of renal biomarkers, handling specific prevention and treatment. With Part II, we are very keen to attract a global audience, welcoming clinical and experimental scientific reports that improve our understanding of novel biomarkers of early renal damage and their possible utilization in clinical practice.

I look forward to your valued submissions that will contribute to this important goal.

Prof. Dr. Yacov Shacham
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute kidney injury
  • biomarkers
  • serum creatinine
  • tubular damage
  • glomerular filtration rate

Published Papers (2 papers)

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Research

8 pages, 441 KiB  
Article
Relation between Serum Creatine Phosphokinase Levels and Acute Kidney Injury among ST-Segment Elevation Myocardial Infarction Patients
by David Zahler, Keren-Lee Rozenfeld, Ilan Merdler, Tamar Itach, Samuel Morgan, Dana Levit, Shmuel Banai and Yacov Shacham
J. Clin. Med. 2022, 11(4), 1137; https://doi.org/10.3390/jcm11041137 - 21 Feb 2022
Cited by 3 | Viewed by 3627
Abstract
Background: Among patients with rhabdomyolysis, the leakage of intracellular skeletal muscle content such as creatine phosphokinase (CPK) into the bloodstream has been associated with an increased risk of acute kidney injury (AKI). We evaluated the possible relationship between serum CPK levels and AKI [...] Read more.
Background: Among patients with rhabdomyolysis, the leakage of intracellular skeletal muscle content such as creatine phosphokinase (CPK) into the bloodstream has been associated with an increased risk of acute kidney injury (AKI). We evaluated the possible relationship between serum CPK levels and AKI occurrence among patients with myocyte injury secondary to ST-elevation myocardial infarction (STEMI). Methods: We retrospectively included 2794 patients with STEMI. Patients were stratified according to peak serum CPK levels into mild (<1000 U/L, n = 1603), moderate (1000–5000 U/L, n = 1111), and severe (>5000 U/L, n = 80) categories. The occurrence of AKI was defined by the KDIGO criteria as an increase in serum creatinine (sCR) ≥0.3 mg/dL within 48 h following PCI. The predictive value of CPK for the risk of AKI occurrence was assessed using multivariate logistic regression models. Results: The overall occurrence of AKI was 10.4%. Incidence of AKI showed a gradual increase between patients with mild, moderate, and severe serum CPK level elevations (7.8% vs. 11% vs. 26% respectively; p < 0.001). In multivariate logistic regression models, both moderate or higher (OR 1.6, 95% CI 1.1–2.2; p = 0.01) and severe (OR 2.8 95% CI 1.4–5.6; p = 0.004) serum CPK level elevations were independently associated with AKI. Conclusions: Among STEMI patients, elevated CPK levels were associated with AKI. This association is presumably independent; however, it remains unclear whether it is due to direct toxic (myoglobin-related) or hemodynamic effects (poor left ventricular function). Further studies are required to reveal the underlying mechanism. Full article
(This article belongs to the Special Issue Novel Biomarkers for the Diagnosis, Prognosis and Management of Acute Kidney Injury—Part II)
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12 pages, 652 KiB  
Article
Hematological Ratios Are Associated with Acute Kidney Injury and Mortality in Patients That Present with Suspected Infection at the Emergency Department
by Titus A. P. de Hond, Gurbey Ocak, Leonie Groeneweg, Jan Jelrik Oosterheert, Saskia Haitjema, Meriem Khairoun and Karin A. H. Kaasjager
J. Clin. Med. 2022, 11(4), 1017; https://doi.org/10.3390/jcm11041017 - 16 Feb 2022
Cited by 7 | Viewed by 2408
Abstract
The early recognition of acute kidney injury (AKI) is essential to improve outcomes and prevent complications such as chronic kidney disease, the need for renal-replacement therapy, and an increased length of hospital stay. Increasing evidence shows that inflammation plays an important role in [...] Read more.
The early recognition of acute kidney injury (AKI) is essential to improve outcomes and prevent complications such as chronic kidney disease, the need for renal-replacement therapy, and an increased length of hospital stay. Increasing evidence shows that inflammation plays an important role in the pathophysiology of AKI and mortality. Several inflammatory hematological ratios can be used to measure systemic inflammation. Therefore, the association between these ratios and outcomes (AKI and mortality) in patients suspected of having an infection at the emergency department was investigated. Data from the SPACE cohort were used. Cox regression was performed to investigate the association between seven hematological ratios and outcomes. A total of 1889 patients were included, of which 160 (8.5%) patients developed AKI and 102 (5.4%) died in <30 days. The Cox proportional-hazards model revealed that the neutrophil-to-lymphocyte ratio (NLR), segmented-neutrophil-to-monocyte ratio (SMR), and neutrophil-lymphocyte-platelet ratio (NLPR) are independently associated with AKI <30 days after emergency-department presentation. Additionally, the NLR, SMR and NLPR were associated with 30-day all-cause mortality. These findings are an important step forward for the early recognition of AKI. The use of these markers might enable emergency-department physicians to recognize and treat AKI in an early phase to potentially prevent complications. Full article
(This article belongs to the Special Issue Novel Biomarkers for the Diagnosis, Prognosis and Management of Acute Kidney Injury—Part II)
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