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Rehabilitation and Management of Multiple Sclerosis
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Rehabilitation and Management of Multiple Sclerosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Rehabilitation".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2466

Special Issue Editors

Dr. Emanuele D'Amico

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Interests: multiple sclerosis; demyelinating disease of the central nervous system; neuroimmunology; motoneuron diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Aurora Zanghì

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Interests: multiple sclerosis; cognitive rehabilitation; demyelinating diseases of the central nervous system; neuroimmunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Multiple Sclerosis (MS) is a complex condition requiring comprehensive, long-term management. Rehabilitation programmes aim to improve function, well-being, and quality of life for people with MS. Currently, a wide variety of rehabilitation therapies are used to treat MS. The evidence suggests that regular specialist evaluation and follow-ups to assess the needs of patients with all types of MS for appropriate rehabilitation interventions may be of benefit, although the certainty of evidence varies across the different types of interventions evaluated via the reviews. Structured, multidisciplinary rehabilitation programmes and physical therapy (exercise or physical activities) can improve functional outcomes (mobility, muscle strength, aerobic capacity) and quality of life. Overall, the evidence for many rehabilitation interventions should be interpreted cautiously, as the majority of included reviews did not include data from current studies. More studies with appropriate designs and which report on the type and intensity of modalities as well as their cos-effectiveness are needed to address the current knowledge gaps in the field of MS.

In this Special Issue, we welcome authors to submit papers on the management of MS and in particular on rehabilitation strategies.

Dr. Emanuele D'Amico
Dr. Aurora Zanghì
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multiple sclerosis
  • rehabilitation
  • physical therapy
  • disability
  • quality of life

Published Papers (3 papers)

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Research

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14 pages, 1243 KiB  
Article
Can Robotic Gait Training with End Effectors Improve Lower-Limb Functions in Patients Affected by Multiple Sclerosis? Results from a Retrospective Case–Control Study
by Mirjam Bonanno, Maria Grazia Maggio, Laura Ciatto, Rosaria De Luca, Angelo Quartarone, Angela Alibrandi and Rocco Salvatore Calabrò
J. Clin. Med. 2024, 13(6), 1545; https://doi.org/10.3390/jcm13061545 - 07 Mar 2024
Viewed by 641
Abstract
Background: Multiple sclerosis (MS) is characterized as a neurodegenerative condition possibly triggered by autoimmune mechanisms, impacting the entire central nervous system. In this context, neurorehabilitation plays a crucial role in every phase of the disease, aiming to restore and preserve motor functions in [...] Read more.
Background: Multiple sclerosis (MS) is characterized as a neurodegenerative condition possibly triggered by autoimmune mechanisms, impacting the entire central nervous system. In this context, neurorehabilitation plays a crucial role in every phase of the disease, aiming to restore and preserve motor functions in MS patients. In particular, robotic gait training (RGT) allows intensive, repetitive, and task-oriented training, which is pivotal in boosting neuroplastic processes. Thus, the primary aim of our study is to evaluate the effectiveness of innovative robotic gait training, using the G-EO system, on gait, functional abilities, and quality of life (QoL) in patients affected by MS. Secondly, we evaluated the effect of the robotic rehabilitation on lower-limb motor functioning, balance, sensation, and joint functioning. Methods: The study involved twenty MS patients, divided into two groups with comparable medical characteristics and rehabilitation training duration. The experimental group (EG) underwent robotic gait training with the G-EO system (n. 10), while the control group (CG) received traditional rehabilitation training (n. 10). Results: Both groups exhibited improvements in disability level (Functional Independence Measure), 10 m walking distance (10MWT), gait, and balance performance (Functional Ambulation Classification, Tinetti Scale). However, the EG demonstrated a more significant improvement. The G-EO system notably reduced spasticity in the lower limbs (Modified Ashworth Scale) exclusively in the EG. Discussion: This study suggests that the G-EO system could be a valuable tool for enhancing gait functions, including lower-limb movements, functional abilities, and QoL in individuals with MS. Full article
(This article belongs to the Special Issue Rehabilitation and Management of Multiple Sclerosis)
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11 pages, 298 KiB  
Article
Effect of Whole-Body Cryotherapy on Oxidant–Antioxidant Imbalance in Women with Multiple Sclerosis
by Bartłomiej Ptaszek, Szymon Podsiadło, Justyna Adamiak, Jakub Marchewka, Łukasz Tota and Aneta Teległów
J. Clin. Med. 2023, 12(18), 5958; https://doi.org/10.3390/jcm12185958 - 13 Sep 2023
Cited by 1 | Viewed by 809
Abstract
The aim of the study was to investigate whether 20 whole-body cryotherapy treatments have an effect on oxidative–antioxidant imbalances in women with multiple sclerosis. Fifty women aged 30–55 were examined: study group—15 women with multiple sclerosis, subjected to whole-body cryotherapy; first control group—20 [...] Read more.
The aim of the study was to investigate whether 20 whole-body cryotherapy treatments have an effect on oxidative–antioxidant imbalances in women with multiple sclerosis. Fifty women aged 30–55 were examined: study group—15 women with multiple sclerosis, subjected to whole-body cryotherapy; first control group—20 women with multiple sclerosis who did not receive cryotherapy intervention; second control group—15 healthy women who participated in cryotherapy treatments. Blood from the examined women was collected twice (before and after the series of 20 cryotherapy sessions). An insignificant increase in the total antioxidant capacity (study group: p = 0.706; second control group: p = 0.602) was observed after the whole-body cryotherapy intervention. After the series of cryotherapy sessions, the total oxidative status/total oxidative capacity value was insignificantly decreased among the multiple sclerosis patients (decrease by 14.03%, p = 0.495). In women with multiple sclerosis, no significant cryotherapy impact was demonstrated on changes in the oxidant–antioxidant imbalance or concentrations of nitric oxide, uric acid, or matrix metalloproteinase-9. Full article
(This article belongs to the Special Issue Rehabilitation and Management of Multiple Sclerosis)

Review

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23 pages, 639 KiB  
Review
Whole-Body Cryostimulation in Multiple Sclerosis: A Scoping Review
by Angelo Alito, Jacopo Maria Fontana, Eleonora Franzini Tibaldeo, Federica Verme, Paolo Piterà, Elzbieta Miller, Riccardo Cremascoli, Andrea Brioschi and Paolo Capodaglio
J. Clin. Med. 2024, 13(7), 2003; https://doi.org/10.3390/jcm13072003 - 29 Mar 2024
Viewed by 714
Abstract
Multiple sclerosis (MS) is the most common cause of non-traumatic long-term disability in young adults. Whole-body cryostimulation (WBC) is a cold-based physical therapy known to induce physiological exercise-mimicking changes in the cardiovascular, neuromuscular, immune, and endocrine systems and to influence functional and psychological [...] Read more.
Multiple sclerosis (MS) is the most common cause of non-traumatic long-term disability in young adults. Whole-body cryostimulation (WBC) is a cold-based physical therapy known to induce physiological exercise-mimicking changes in the cardiovascular, neuromuscular, immune, and endocrine systems and to influence functional and psychological parameters by exposing the human body to cryogenic temperatures (≤−110 °C) for 2–3 min. The purpose of this scoping review is to present an overall view on the potential role of WBC as an adjuvant therapy in the treatment of MS. PubMed, ScienceDirect, Embase, and Web of Science were searched up to 30 November 2023, and a total of 13 articles were included. WBC may have beneficial antioxidant effects as a short-term adjuvant treatment in MS. There were no significant changes in antioxidant enzymes, nitric oxide levels, metalloproteinase levels, blood counts, rheology, and biochemistry. WBC can lead to a reduction in fatigue and an improvement in functional status, with a significant effect on both mental and physical well-being. There were no reported adverse effects. The results suggest that WBC may complement therapeutic options for patients with MS, as the effects of cryogenic cold stimulation have been shown to activate antioxidant processes and improve functional status, mood, anxiety, and fatigue. Full article
(This article belongs to the Special Issue Rehabilitation and Management of Multiple Sclerosis)
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