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Cardiac Arrhythmias in Clinical Practice
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Cardiac Arrhythmias in Clinical Practice

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1692

Special Issue Editor

Dr. Andrea Frustaci

E-Mail Website
Guest Editor
Cellular and Molecular Cardiology Lab, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy
Interests: myocarditis; cardiomyopathies; heart failure; endomyocardial biopsy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Coming across cardiac arrhythmias is a frequent clinical challenge in cardiovascular medicine. The pathologic substrate that is at the origin of electrical instability is often elusive, while the electrogenetic mechanisms involved are still debated. This Special Issue aims to recall the contribution of varied specialists dealing with the topic to update their cause and pathway as well as to design a specific investigative flowchart finalized for a personalized treatment.

Actually, many therapeutic solutions are available as antiarrhythmic drugs, anti-inflammatory, immunomodulating, and immunosuppressive agents for autoreactive myocarditis, anti-infectious solutions based on recognition via the Polymerase Chain Reaction in endomyocardial tissue samples of specific infectious agents, and, finally, the electrophysiologic mapping and ablation of arrhythmic foci.

The arrhythmogenic role of damaged Conduction Tissue (CT) is still under definition while its histological and immunohistochemical approach appears obtainable in 30‒40% of endomyocardial biopsies.

Clarifying the responsibilities of CT damage in the generation of cardiac arrhythmias may promote the identification of biomarkers as anti-intercalated disk and anti-HCN4 antibodies that can help to have non-invasive indications on arrhythmogenic mechanisms and possible therapeutic indications.

I believe many gaps in the knowledge about cardiac arrhythmogenesis are still present and that your contribution could be crucial for their clarification.

Dr. Andrea Frustaci
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • histology of myocardial substrate
  • pathology of conduction tissue
  • potential biomarkers of cardiac arrhythmias (i.e., serum determination of antibodies for the intercalated disk)
  • anti-arrhythmic drugs
  • mapping and ablation of arrhythmic foci
  • ICD implantation (implantable cardioverter defibrillator)

Published Papers (2 papers)

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Research

12 pages, 823 KiB  
Article
Effects of Premature Ventricular Complex Burden on Left Ventricular Global Longitudinal Strain in Patients without Structural Heart Disease
by Arslan Sukru, Arabaci H. Ozan, Deniz M. Furkan, Gokce M. Emin, Arslan Seyma, Oktay Veysel, Yıldız Mustafa and Uzunhasan Isıl
J. Clin. Med. 2024, 13(6), 1796; https://doi.org/10.3390/jcm13061796 - 20 Mar 2024
Viewed by 495
Abstract
Background: Evaluation of left ventricular (LV) function in patients with idiopathic premature ventricular contraction (PVC) with preserved LV ejection fraction (LVEF), especially in the subclinical stage, may be of great importance in terms of directing early treatment. Methods: A total of 122 patients, [...] Read more.
Background: Evaluation of left ventricular (LV) function in patients with idiopathic premature ventricular contraction (PVC) with preserved LV ejection fraction (LVEF), especially in the subclinical stage, may be of great importance in terms of directing early treatment. Methods: A total of 122 patients, retrospectively recruited, were divided into three groups according to PVC burden: Group 1; 5% ≤ PVC < 10%, Group 2; 10% ≤ PVC < 15%, and Group 3; 15% ≤ PVC. Transthoracic echocardiography (TTE) was performed to evaluate LV parameters. Results: LV-GLS (Global longitudinal strain) was found to be significantly lower in groups 2 and 3 with high PVC burden (18.9% ± 1.4, 17.5% ± 2.1, 16.3% ± 1.3; p < 0.001, respectively). Correlation analysis revealed a positive and significant correlation between PVC burden and deterioration in LV-GLS (r: 0.536; p < 0.001). In addition, PVC burden was found to be an independent predictor of LV-GLS deterioration in multiple linear regression analysis (β: 0.525, p < 0.001). The ROC curve analysis demonstrated that a PVC burden cut-off value of 8.4% was associated with a LV-GLS deterioration greater than −18, with a specificity of 75.4% and a sensitivity of 75.4% (AUC: 0.81 [0.73–0.88] 95% CI; p < 0.001). Conclusions: PVC burden was an independent predictor of deterioration in LV-GLS. The presence of LV-GLS deterioration due to PVC burden emphasizes the necessity for closer patient monitoring, observation of the response to pharmacological treatment, and evaluation of early invasive treatment strategies in selected patient groups. Full article
(This article belongs to the Special Issue Cardiac Arrhythmias in Clinical Practice)
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11 pages, 11047 KiB  
Article
Catecholaminergic Polymorphic Ventricular Tachycardia: Multiple Clinical Presentations of a Genetically Determined Disease
by Stjepan Jurisic, Argelia Medeiros-Domingo, Florian Berger, Christian Balmer, Corinna Brunckhorst, Frank Ruschitzka, Ardan M. Saguner and Firat Duru
J. Clin. Med. 2024, 13(1), 47; https://doi.org/10.3390/jcm13010047 - 21 Dec 2023
Cited by 1 | Viewed by 986
Abstract
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare, inherited heart rhythm disorder that is caused by variants in genes responsible for cardiac calcium homeostasis. The aim of this study was to analyze different genotype-specific clinical manifestations of this disease. Methods and Results: [...] Read more.
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare, inherited heart rhythm disorder that is caused by variants in genes responsible for cardiac calcium homeostasis. The aim of this study was to analyze different genotype-specific clinical manifestations of this disease. Methods and Results: We analyzed five CPVT cases from our institution in the context of specific patient characteristics and genotype–phenotype correlations. In this cohort, three of the index patients were male. The median age at diagnosis was 11 (11–30) years, and median age at disease onset was 12 (12–33) years. Four index patients suffered from syncope, while one female index patient suffered from out-of-hospital cardiac arrest. Two index patients experienced concomitant atrial flutter and atrial fibrillation. Three patients received an implantable cardioverter defibrillator and one patient received an event recorder. All index patients had causative genetic variants in the RYR2-gene. Conclusions: This study presents various phenotypic presentations of patients with CPVT harboring different pathogenic variants in the RYR2 gene, some of which have not previously been described in published studies. Syncope was the most prevalent symptom on admission. Adjustment of beta-blocker therapy may be necessary due to side effects. Moreover, our work further highlights the common occurrence of atrial tachyarrhythmias in these patients. Full article
(This article belongs to the Special Issue Cardiac Arrhythmias in Clinical Practice)
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