Dear Colleagues,

The management of osteoarticular infections poses a challenge in clinical practice, and a multidisciplinary approach must be taken by microbiologists, infectious disease specialists, and orthopaedic surgeons for their successful eradication. The rising number of multiresistant pathogens over the past decade is especially worrisome, calling for new diagnostic and treatment strategies. During the COVID-19 pandemic, the problem of multiresistant pathogens worsened as antimicrobial stewardship was challenging during these years, and use of broad-spectrum antibiotics, without clear indications in many cases, significantly increased. Moreover, the long duration of antibiotic therapy that is recommended in many osteoarticular infections has also contributed to the emergence of antibiotic resistance, especially in patients with osteoarticular infections.

This Special Issue focuses on the antibiotic management of osteomyelitis, spondylodiscitis, septic arthritis, and periprosthetic infections in paediatric patients, adults, and immunocompromised patients such as cancer patients. Specifically, our goal is to shed light on certain aspects of antibiotic management, such as the optimal antibiotic regime, the ideal route of administration, and the recommended duration of antibiotic therapy for patients with osteoarticular infections. Moreover, recent advances, including newer antibiotics with optimal pharmacokinetics for osseous administration, will be discussed, and the efficacy of these new antibiotics will be evaluated through clinical studies. The microbiology of osteoarticular infections also varies between countries and populations; therefore, differences in antibiotic regimes based on geography must be evaluated through robust clinical research. This issue will include studies that employ experimental models of osteomyelitis in order to assess the in vivo and in vitro efficacy of newer antibiotics. Original research articles, reviews, and case reports are welcome.

You may choose our Joint Special Issue in Antibiotics.

Dr. Andreas G. Tsantes
Dr. Dimitrios V. Papadopoulos
Dr. Christos Koutserimpas
Guest Editors

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• ostoarticular infections
• osteomyelitis
• septic arthritis
• periprosthetic infections
• antibiotics
• therapy