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Head and Neck Surgery: Clinical Updates on Diagnosis, Management and...
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Head and Neck Surgery: Clinical Updates on Diagnosis, Management and Prognosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 1434

Special Issue Editors

Prof. Dr. Gabriele Molteni

E-Mail Website
Guest Editor
Otolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna , Via giuseppe Massarenti 9, 40138 Bologna, Italy
Interests: head and neck surgery; microvascular reconstruction; thyroid and parathyroid; larynx; artificial intelligence
Prof. Dr. Albino Eccher

E-Mail Website
Guest Editor
Department of Pathology, Universitary Hospital Policlinico di Modena, University of Modena and Reggio Emilia, via del Pozzo 71, 41125 Modena, Italy
Interests: immunohistochemistry; transplantation pathology; digital pathology; cytopathology; artificial intelligence

Special Issue Information

Dear Colleagues,

Head and neck tumors globally have a high impact on patients’ survival and quality of life. The progress in medical devices and artificial intelligence are remarkable and have led to more attention being given to patients’ reported outcome evaluations; now, both clinical and laboratory research should focus on improving patients’ survival and quality of life. Moreover, many topics related to head and neck cancer diagnosis, treatment and management are still widely debated. Therapeutic indications have expanded steadily, and new therapies are being developed and implemented; the early results are promising, but need to be confirmed with more clinical trials and publications. In this Special Issue, we welcome authors to submit papers on clinical updates in terms of the diagnosis, management and prognosis of head and neck tumors. We welcome papers on new treatments, technology, AI and possible future perspectives.

Prof. Dr. Gabriele Molteni
Prof. Dr. Albino Eccher
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck surgery
  • laryngeal cancer
  • immunotherapy
  • AI
  • head and neck radiology

Published Papers (3 papers)

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Research

9 pages, 1097 KiB  
Article
Association of the Specimen and Tumor Bed Margin Status with Local Recurrence and Survival in Open Partial Laryngectomy
by Rogério Aparecido Dedivitis, Leandro Luongo de Matos, Mario Augusto Ferrari de Castro and Luiz Paulo Kowalski
J. Clin. Med. 2024, 13(9), 2491; https://doi.org/10.3390/jcm13092491 - 24 Apr 2024
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Abstract
Background/Objectives: Positive margins are associated with locoregional recurrence in early laryngeal cancer. The aim of this study was to evaluate the impacts of specimen-driven (ex vivo) positive margins on patients with early-stage laryngeal cancer whose tumor bed (defect-driven) margins had been negative. [...] Read more.
Background/Objectives: Positive margins are associated with locoregional recurrence in early laryngeal cancer. The aim of this study was to evaluate the impacts of specimen-driven (ex vivo) positive margins on patients with early-stage laryngeal cancer whose tumor bed (defect-driven) margins had been negative. Methods: A retrospective study was performed on 60 consecutive T1b/T2 glottic cancer patients who underwent open frontolateral laryngectomy. The intraoperative margins were obtained from the tumor bed. Their recurrence and disease-free survival were evaluated. In all cases, negative margins were obtained from the surgical bed. The impact of positive margins from the specimen was evaluated in a paraffin study. Results: Among 10 patients with positive margins in the specimen, six experienced local relapse, and among 50 patients with negative margins in the specimen, three developed recurrence. The 5-year disease-free survival rates were 37.5% and 93.9%, respectively (p < 0.001; log-rank). Even with negative margins in the surgical bed, patients with positive margins in the specimen at the final histopathological examination had a 3.5-fold higher chance of developing local recurrence than those with negative margins (HR = 13.993; 95% CI: 3.479–56.281; p < 0.001; univariate Cox regression). Conclusions: Specimen-driven positive margins represent a significant risk factor for local recurrence, even under negative margins at the tumor bed. Full article
(This article belongs to the Special Issue Head and Neck Surgery: Clinical Updates on Diagnosis, Management and Prognosis)
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15 pages, 1317 KiB  
Article
Impact of the COVID-19 Pandemic on Head and Neck Cancer Management: The Experience of the Maxillo-Facial Surgery Department of a French Regional Referral Center in a High-Incidence Area
by Emilien Colin, Agnès Paasche, Alban Destrez, Bernard Devauchelle, Jérémie Bettoni, Julien Bouquet, Stéphanie Dakpé and Sylvie Testelin
J. Clin. Med. 2024, 13(8), 2439; https://doi.org/10.3390/jcm13082439 - 22 Apr 2024
Viewed by 250
Abstract
Background: Cancer patients are at a high risk of complications in cases of infection, and head and neck cancers (HNC) are no exception. Since late 2019, SARS-CoV-2 has caused a global health crisis, with high rates and severe forms of the disease in [...] Read more.
Background: Cancer patients are at a high risk of complications in cases of infection, and head and neck cancers (HNC) are no exception. Since late 2019, SARS-CoV-2 has caused a global health crisis, with high rates and severe forms of the disease in cancer patients. Hospitalization, surgery and radiotherapy were rapidly described as increasing the risk of infection. Since March 2020, the Amiens University Hospital (France) has been taking care of COVID-19 patients while its maxillofacial surgery department managed HNC patients without interruption, even during lockdown periods. However, many questions concerning the impact on patient care were still pending. The aim of this study is to describe HNC management in our center during the first epidemic peak and to evaluate the impact of containment measures on patient treatment. Methods: We retrospectively included 44 HNC patients treated in our department between 1 March and 31 August 2020. Two groups were defined according to the period of care: lockdown (March to May) and lighter restrictions (June to August). Results: The results show typical epidemiological characteristics, maintained management times and non-downgraded procedures. Conclusions: Thus, during the first epidemic peak, continuity of care and patients’ safety could be ensured thanks to adequate means, adapted procedures and an experienced surgical team. Full article
(This article belongs to the Special Issue Head and Neck Surgery: Clinical Updates on Diagnosis, Management and Prognosis)
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12 pages, 4580 KiB  
Article
Digital Pathology Applications for PD-L1 Scoring in Head and Neck Squamous Cell Carcinoma: A Challenging Series
by Valentina Canini, Albino Eccher, Giulia d’Amati, Nicola Fusco, Fausto Maffini, Daniela Lepanto, Maurizio Martini, Giorgio Cazzaniga, Panagiotis Paliogiannis, Renato Lobrano, Vincenzo L’Imperio and Fabio Pagni
J. Clin. Med. 2024, 13(5), 1240; https://doi.org/10.3390/jcm13051240 - 22 Feb 2024
Viewed by 658
Abstract
The assessment of programmed death-ligand 1 (PD-L1) combined positive scoring (CPS) in head and neck squamous cell carcinoma (HNSCC) is challenged by pre-analytical and inter-observer variabilities. An educational program to compare the diagnostic performances between local pathologists and a board of pathologists on [...] Read more.
The assessment of programmed death-ligand 1 (PD-L1) combined positive scoring (CPS) in head and neck squamous cell carcinoma (HNSCC) is challenged by pre-analytical and inter-observer variabilities. An educational program to compare the diagnostic performances between local pathologists and a board of pathologists on 11 challenging cases from different Italian pathology centers stained with PD-L1 immunohistochemistry on a digital pathology platform is reported. A laboratory-developed test (LDT) using both 22C3 (Dako) and SP263 (Ventana) clones on Dako or Ventana platforms was compared with the companion diagnostic (CDx) Dako 22C3 pharm Dx assay. A computational approach was performed to assess possible correlations between stain features and pathologists’ visual assessments. Technical discordances were noted in five cases (LDT vs. CDx, 45%), due to an abnormal nuclear/cytoplasmic diaminobenzidine (DAB) stain in LDT (n = 2, 18%) and due to variation in terms of intensity, dirty background, and DAB droplets (n = 3, 27%). Interpretative discordances were noted in six cases (LDT vs. CDx, 54%). CPS remained unchanged, increased, or decreased from LDT to CDx in three (27%) cases, two (18%) cases, and one (9%) case, respectively, around relevant cutoffs (1 and 20, k = 0.63). Differences noted in DAB intensity/distribution using computational pathology partly explained the LDT vs. CDx differences in two cases (18%). Digital pathology may help in PD-L1 scoring, serving as a second opinion consultation platform in challenging cases. Computational and artificial intelligence tools will improve clinical decision-making and patient outcomes. Full article
(This article belongs to the Special Issue Head and Neck Surgery: Clinical Updates on Diagnosis, Management and Prognosis)
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