Special Issue "Primary and Secondary Cardiovascular Disease Risk Factors, Prevention and Therapy"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 15 February 2024 | Viewed by 769

Special Issue Editors

Cardiology Division, Spedali Civili and University of Brescia, Brescia, Italy
Interests: cardiovascular prevention and rehabilitation; echocardiography; valve disease
Prof. Dr. Roberto Lorusso
E-Mail Website
Guest Editor
Cardio-Thoracic Surgery Department, Maastricht University Medical Centre (MUMC+), 6202 AZ Maastricht, The Netherlands
Interests: cardio-thoracic surgery

Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) remain the number one cause of morbidity and mortality worldwide.

In the last few decades, several advancements in the diagnosis and treatment, both medical and surgical, of overt CVD have been developed and have entered clinical practice. This has caused a reduction in the mortality and hospitalization rates associated with several conditions, such as acute myocardial infarction, multivessel coronary artery disease, advanced valve disease and heart failure. However, the incidence rates of new cases of cardiac disease and their serious complications remain very high. 

The prevention of both primary and secondary CVD represents a fundamental approach to reduce the burden of CVD worldwide. The aim of this Special Issue of JCM is to offer updated information in the field of CVD prevention.

List of potential topics:

  • The epidemiology of cardiovascular disease and risk factors worldwide;
  • The pathogenesis of atherosclerotic plaque and mechanisms leading to acute cardiovascular events;
  • Population and patient strategies for primary CVD;
  • Strategies to improve lifestyle habits;
  • From the international guidelines for CVD prevention to real-world data: the gap between theory and practice;
  • The issue of therapeutic adherence: a new risk factor;
  • Combination therapy and polypill;
  • After acute coronary syndrome: from the first month to the first year and beyond: how to reduce the long-term risk;
  • After cerebrovascular and peripheral artery disease: should the same secondary prevention as for coronary artery disease be used?;
  • How to prevent stent disease or graft venous disease;
  • How to prevent biologic valve degeneration;
  • How to prevent left ventricle remodeling;
  • Coronary artery and valve disease post mediastinal irradiation;
  • Ischemic left ventricular dysfunction and advanced heart failure: prevention strategies.

The topics of interest are not limited to this list; many more are welcome.

Researchers are invited to submit original and review manuscripts related to all aspects of CVD prevention.

Prof. Dr. Pompilio Faggiano
Prof. Dr. Roberto Lorusso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cardiovascular disease
  • atherosclerotic plaque
  • risk factors of cardiovascular disease
  • epidemiology
  • peripheral artery disease
  • coronary artery disease
  • graft venous disease
  • valve degeneration
  • left ventricle remodeling
  • ischemic left ventricular dysfunction
  • advanced heart failure
  • therapy
  • prevention

Published Papers (1 paper)

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Effects of Antihypertensive Treatment on Left and Right Ventricular Global Longitudinal Strain and Diastolic Parameters in Patients with Hypertension and Obstructive Sleep Apnea: Randomized Clinical Trial of Chlorthalidone plus Amiloride vs. Amlodipine
J. Clin. Med. 2023, 12(11), 3785; https://doi.org/10.3390/jcm12113785 - 31 May 2023
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Hypertension is highly prevalent in patients with obstructive sleep apnea (OSA), and fluid retention with its nighttime rostral distribution is one potential mechanism. We tested whether or not diuretics differ from amlodipine in their impact on echocardiographic parameters. Patients with moderate OSA and [...] Read more.
Hypertension is highly prevalent in patients with obstructive sleep apnea (OSA), and fluid retention with its nighttime rostral distribution is one potential mechanism. We tested whether or not diuretics differ from amlodipine in their impact on echocardiographic parameters. Patients with moderate OSA and hypertension were randomized to receive diuretics (chlorthalidone plus amiloride) or amlodipine daily for 8 weeks. We compared their effects on left and right ventricular global longitudinal strain (LV-GLS and RV-GLS, respectively), on LV diastolic parameters, and on LV remodeling. In the 55 participants who had echocardiographic images feasible for strain analysis, all echocardiographic parameters were within normal ranges. After 8 weeks, the 24 h blood pressure (BP) reduction values were similar, while most echocardiographic metrics were kept unchanged, except for LV-GLS and LV mass. In conclusion, the use of diuretics or amlodipine had small and similar effects on echocardiographic parameters in patients with moderate OSA and hypertension, suggesting that they do not have important effects on mediating the interaction between OSA and hypertension. Full article
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