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New Clinical Advances within the Gut–Skin Axis
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New Clinical Advances within the Gut–Skin Axis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 11560

Special Issue Editor

Dr. Raja K. Sivamani

E-Mail Website
Guest Editor
1. Zen Dermatology, Sacramento, CA 95819, USA
2. Integrative Skin Science and Research, Sacramento, CA 95815, USA
3. Department of Dermatology, University of California-Davis, Sacramento, CA 95616, USA
4. College of Medicine, California Northstate University, Elk Grove, CA 95757, USA
5. Pacific Skin Institute, Sacramento, CA 95815, USA
Interests: dermatology; nutrition; botanicals; gut-skin axis; probiotics; acne and sebaceous gland disease; medical devices

Special Issue Information

Dear Colleagues,

Many skin problems actually start in the gut. Research has found that acne is less a problem of the skin than a problem of the gut. Communication between the immune system, skin and brain is mediated by microbes. The intestinal flora is unbalanced, and harmful bacteria multiply and promote the release of inflammatory substances, which can also cause skin problems such as acne. For example, atopic dermatitis is the most common chronic itching inflammatory skin disease, and psoriasis is a disease caused by immune-mediated chronic inflammatory skin disease.

This Special Issue, which focuses on the skin and the gut immune system, will serve as a valuable tool to broaden readers’ knowledge of the complexities of certain skin disorders and the important role played by the immune system. We welcome your contribution of the latest articles/reviews.

Dr. Raja K. Sivamani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin
  • immunity
  • inflammation
  • dermatitis
  • psoriasis
  • gut–skin axis
  • acne
  • rosacea
  • eczema

Published Papers (3 papers)

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Research

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12 pages, 2625 KiB  
Article
Prospective Randomized Double-Blind Placebo-Controlled Study of Oral Pomegranate Extract on Skin Wrinkles, Biophysical Features, and the Gut-Skin Axis
by Mincy Chakkalakal, Dawnica Nadora, Nimrit Gahoonia, Ashley Dumont, Waqas Burney, Adrianne Pan, Cindy J. Chambers and Raja K. Sivamani
J. Clin. Med. 2022, 11(22), 6724; https://doi.org/10.3390/jcm11226724 - 14 Nov 2022
Cited by 5 | Viewed by 5255
Abstract
(1) Background: The pomegranate fruit (Punica granatum L.) has been widely used in traditional medicine and has increasingly gained popularity among consumers in order to manage different facets of health. The objective of this study was to evaluate the effects of the fruit [...] Read more.
(1) Background: The pomegranate fruit (Punica granatum L.) has been widely used in traditional medicine and has increasingly gained popularity among consumers in order to manage different facets of health. The objective of this study was to evaluate the effects of the fruit extract of P. granatum L. on different parameters of skin health. (2) Methods: A prospective, double-blind placebo-controlled study was conducted on both healthy males and females aged 25–55 years. Subjects were supplemented with a standardized punicalagin enriched oral pomegranate extract [Pomella® (Verdure Science, Noblesville, IN, USA), PE group] or a placebo (control group) daily for four weeks. Changes in wrinkle severity, facial biophysical properties, skin microbiome, and the gut microbiome were assessed. (3) Results: The PE group had significant reductions in wrinkle severity (p < 0.01) and a decreasing trend in the forehead sebum excretion rate (p = 0.14). The participants in the PE group with a higher relative abundance of Eggerthellaceae in the gut had a decrease in their facial TEWL (p < 0.05) and wrinkle severity (p = 0.058). PE supplementation led to an increase in the Staphylococcus epidermidis species and the Bacillus genus on the skin. (4) Conclusions: Overall, the study demonstrated improvements in several biophysical properties, wrinkles, and shifts in the skin microbiome with oral PE supplementation in healthy subjects. Full article
(This article belongs to the Special Issue New Clinical Advances within the Gut–Skin Axis)
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Review

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10 pages, 271 KiB  
Review
Vegan Diet in Dermatology: A Review
by Hannah Lee, Nathan Sim, Audrey Fotouhi and Steven Daveluy
J. Clin. Med. 2023, 12(18), 5800; https://doi.org/10.3390/jcm12185800 - 6 Sep 2023
Cited by 1 | Viewed by 3702
Abstract
Diet is known to play a role in the development of skin disorders. While a vegan diet is frequently described as a risk factor for skin disease secondary to nutritional deficiency, this risk may be overestimated. This review aims to debunk myths and [...] Read more.
Diet is known to play a role in the development of skin disorders. While a vegan diet is frequently described as a risk factor for skin disease secondary to nutritional deficiency, this risk may be overestimated. This review aims to debunk myths and provide information on skin disorders and inflammatory skin conditions that have associations with specific nutritional deficiencies in the context of a vegan diet. A literature search was performed for each nutrient and inflammatory skin disease using the PubMed/MEDLINE database and public health website pages concerning a vegan diet. The literature has individual cases reporting skin disease due to deficiencies in vitamin B2 and vitamin A in patients following a vegan diet. The recommended daily amounts of nutrients and vitamins can be fulfilled on a vegan diet. Vegan diets also avoid food groups such as dairy and other animal-based products, which holds benefits in inflammatory skin diseases including acne, psoriasis, hidradenitis suppurativa, and atopic dermatitis. Overall, the risk of skin disease secondary to nutritional deficiency in patients following a vegan diet is very low and likely over-emphasized. A well-balanced and conscientiously planned vegan diet can adequately provide the necessary amounts of proteins, vitamins, and minerals to support skin health. Full article
(This article belongs to the Special Issue New Clinical Advances within the Gut–Skin Axis)
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Other

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7 pages, 599 KiB  
Perspective
Atopic Dermatitis: Beyond the Skin and Into the Gut
by Rachel L. Sadowsky, Pranvera Sulejmani and Peter A. Lio
J. Clin. Med. 2023, 12(17), 5534; https://doi.org/10.3390/jcm12175534 - 25 Aug 2023
Cited by 3 | Viewed by 1701
Abstract
Atopic dermatitis (AD) is a common, chronic and recurring inflammatory skin disorder characterized by an intensely pruritic, eczematous dermatitis. The etiology of AD is thought to involve a combination of environmental, genetic, and immunologic factors. Emerging research has investigated factors that may impact [...] Read more.
Atopic dermatitis (AD) is a common, chronic and recurring inflammatory skin disorder characterized by an intensely pruritic, eczematous dermatitis. The etiology of AD is thought to involve a combination of environmental, genetic, and immunologic factors. Emerging research has investigated factors that may impact individual risk for developing AD, disease severity, and treatment response. One component is the gut microbiome, which is considered to play an essential role in maintaining the homeostasis of several organ systems. The gut microbiome has been described as a major regulator of the “gut–skin axis,” yet some studies have yielded conflicting evidence regarding the strength of the association of gut microbiota dysbiosis with AD. This review discusses recent insights into the role of the gut microbiome in AD pathogenesis and its interplay among other complex systems that govern the current assessments of and treatments for AD. Full article
(This article belongs to the Special Issue New Clinical Advances within the Gut–Skin Axis)
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