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Special Issues
Recent Advancements and Challenges in Colorectal Surgery
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Recent Advancements and Challenges in Colorectal Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 1369

Special Issue Editors

Dr. Georgios D. Lianos

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Guest Editor
Department of Surgery, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece
Interests: colorectal cancer; minimally invasive surgery; surgical oncology; personalized cancer medicine
Dr. Christina Bali

E-Mail Website
Guest Editor
Department of Surgery, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece
Interests: colorectal cancer; minimally invasive surgery; surgical oncology; personalized cancer medicine
Prof. Dr. Konstantinos Vlachos

E-Mail Website
Guest Editor
Department of Surgery, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece
Interests: colorectal cancer; minimally invasive surgery; surgical oncology; personalized cancer medicine
Prof. Dr. Michail Mitsis

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Guest Editor
Department of Surgery, University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece
Interests: colorectal surgery; laparotomy; minimally invasive surgery; surgical oncology; personalized cancer medicine

Special Issue Information

Dear Colleagues,

Colorectal cancer represents one of the most common cancers in the world. The treatment and screening of colorectal cancer has significantly evolved the last twenty years. However, colorectal cancer is still a ‘deadly’ cancer. Due to the prognostic value of lymphadenectomy, the use of multimodal strategies, and research on molecular pathways, we hope that the mortality rate will significantly decrease in the future. Furthermore, the potential role of minimally invasive (laparoscopic and robotic) approaches and the impact of ERAS protocols have been under investigation in large trial studies. Current treatment approaches, multimodal management, minimally invasive treatment, the use of fluorescent methods, the role of multidisciplinary meetings, progress in treating advanced diseases, screening in early stages, and much more will be discussed in this Special Issue. We hope to investigate all aspects of colorectal cancer research. We await receiving original articles, reviews, systematic reviews, metanalyses, and clinical research. With this Special Issue, we aim also to provide a ‘view’ of the future of colorectal cancer treatment.

Dr. Georgios D. Lianos
Dr. Christina Bali
Prof. Dr. Konstantinos Vlachos
Prof. Dr. Michail Mitsis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • tumorigenesis
  • precision oncology
  • minimally invasive approaches
  • fluorescent methods
  • extended lymphadenectomy
  • multimodal management

Published Papers (1 paper)

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Research

10 pages, 529 KiB  
Article
The Impact of Mechanical Bowel Preparation and Oral Antibiotics in Colorectal Cancer Surgery (MECCA Study): A Prospective Randomized Clinical Trial
by Maximos Frountzas, Victoria Michalopoulou, Georgia Georgiou, Despoina Kanata, Maria Matiatou, Despina Kimpizi, Georgia Matthaiou, Spilios Spiliotopoulos, Dimitrios Vouros, Konstantinos G. Toutouzas and George E. Theodoropoulos
J. Clin. Med. 2024, 13(4), 1162; https://doi.org/10.3390/jcm13041162 - 19 Feb 2024
Cited by 1 | Viewed by 808
Abstract
Background: Colorectal cancer surgery has been associated with surgical site infections (SSIs), leading to an increase in postoperative morbidity, length of stay and total cost. The aim of the present randomized study was to investigate the relationship between the preoperative administration of oral [...] Read more.
Background: Colorectal cancer surgery has been associated with surgical site infections (SSIs), leading to an increase in postoperative morbidity, length of stay and total cost. The aim of the present randomized study was to investigate the relationship between the preoperative administration of oral antibiotic therapy and SSI rate, as well as other postoperative outcomes in patients undergoing colorectal cancer surgery. Material and Methods: Patients who underwent colorectal cancer surgery in a university surgical department were included in the present study. Patients were randomized into two groups using the “block randomization” method. The intervention group received three doses of 400 mg rifaximin and one dose of 500 mg metronidazole per os, as well as mechanical bowel preparation the day before surgery. The control group underwent only mechanical bowel preparation the day before surgery. The study has been registered in ClinicalTrials.gov (NCT03563586). Results: Two hundred and five patients were finally included in the present study, 97 of whom received preoperative antibiotic therapy per os (intervention group). Patients of this group demonstrated a significantly lower SSI rate compared with patients who did not receive preoperative antibiotic therapy (7% vs. 16%, p = 0.049). However, preoperative antibiotic administration was not correlated with any other postoperative outcome (anastomotic leak, overall complications, readmissions, length of stay). Conclusions: Preoperative antibiotic therapy in combination with mechanical bowel preparation seemed to be correlated with a lower SSI rate after colorectal cancer surgery. Full article
(This article belongs to the Special Issue Recent Advancements and Challenges in Colorectal Surgery)
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