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Update on Laparoscopic Management of Gynecologic Malignancies
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Update on Laparoscopic Management of Gynecologic Malignancies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 1661

Special Issue Editor

Dr. Liliana Mereu

E-Mail Website
Guest Editor
Director of Gynecologic and Obstetrics Department, Policlinico G Rodolico, University of Catania, 95123 Catania, Italy
Interests: gynecologic oncology; endometriosis; urogynecology minimal invasive surgery; new technologies; robotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the last few years, there has been a notable development in the management of gynecological cancers towards precision medicine, characterized by personalization and minimal invasiveness. In particular, developments from a genetic, technological and molecular point of view have allowed an ever greater integration between diagnostics, surgical treatment and adjuvant treatments, with the aim of improving the survival and quality of life of cancer patients. In this Special Issue, we invite authors to submit papers on the rule of laparoscopy in the management of patients with gynecological cancer for diagnosis, primary surgical treatment, secondary surgical treatment, different minimal invasive approaches and new technologies.

Dr. Liliana Mereu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometrial cancer
  • cervical cancer
  • ovarian cancer
  • lymphadenectomy
  • minimally invasive surgery
  • laparoscopy
  • hysteroscopy
  • robotics

Published Papers (2 papers)

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Review

17 pages, 1380 KiB  
Review
Endometriosis-Related Ovarian Cancer: Where Are We Now? A Narrative Review towards a Pragmatic Approach
by Gabriele Centini, Giorgia Schettini, Emilio Pieri, Matteo Giorgi, Lucia Lazzeri, Francesco Giuseppe Martire, Virginia Mancini, Diego Raimondo, Renato Seracchioli, Nassir Habib, Francesco Fedele and Errico Zupi
J. Clin. Med. 2024, 13(7), 1933; https://doi.org/10.3390/jcm13071933 - 27 Mar 2024
Viewed by 661
Abstract
Background: Endometriosis affects more than 10% of reproductive-aged women, causing pelvic pain and infertility. Despite the benign nature of endometriosis, ovarian endometriomas carry a higher risk of developing endometrioid carcinomas (EnOCs) and clear cell ovarian carcinomas (CCCs). Atypical endometriosis, defined as cytological atypia [...] Read more.
Background: Endometriosis affects more than 10% of reproductive-aged women, causing pelvic pain and infertility. Despite the benign nature of endometriosis, ovarian endometriomas carry a higher risk of developing endometrioid carcinomas (EnOCs) and clear cell ovarian carcinomas (CCCs). Atypical endometriosis, defined as cytological atypia resembling intraepithelial cancer, is considered the precursor of endometriosis-associated ovarian cancer (EAOC). This narrative review aims to provide an overview of EAOC, proposing a practical approach to clinical and therapeutic decision making. Methods: An electronic literature search was conducted from inception up to January 2023, using the MEDLINE database via PubMed to evaluate the existing literature on EAOC, including its pathogenesis, the diagnostic process, and the therapeutic possibilities, with articles not relevant to the topic or lacking scientific merit being excluded. Results: Eighty-one articles were included in the review to present the current state of the art regarding EAOC. A pragmatic clinical flowchart is proposed to guide therapeutic decisions and improve patient outcomes. Conclusions: Endometriosis patients may have an increased risk of developing EAOC (either EnOC or CCC). Despite not being fully accepted, the concept of AE may reshape the endometriosis–ovarian cancer relationship. Further research is needed to understand the unaddressed issues. Full article
(This article belongs to the Special Issue Update on Laparoscopic Management of Gynecologic Malignancies)
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25 pages, 2690 KiB  
Review
Uterine Tumours Resembling Ovarian Sex-Cord Tumors: A Case Report and Review of the Literature
by Martina Ferrara, Basilio Pecorino, Maria Gabriella D’Agate, Giuseppe Angelico, Ettore Domenico Capoluongo, Umberto Malapelle, Francesco Pepe, Paolo Scollo and Liliana Mereu
J. Clin. Med. 2023, 12(22), 7131; https://doi.org/10.3390/jcm12227131 - 16 Nov 2023
Cited by 2 | Viewed by 807
Abstract
Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are thought to develop from pluripotent uterine mesenchymal cells or endometrial stromal cells with secondary sex-cord differentiation. The patient was a 73-year-old postmenopausal woman who had abnormal vaginal bleeding, and she underwent a laparoscopic hysterectomy with [...] Read more.
Uterine tumors resembling ovarian sex-cord tumors (UTROSCT) are thought to develop from pluripotent uterine mesenchymal cells or endometrial stromal cells with secondary sex-cord differentiation. The patient was a 73-year-old postmenopausal woman who had abnormal vaginal bleeding, and she underwent a laparoscopic hysterectomy with bilateral salpingo-oophorectomy. The diagnosis was a case of UTROSCT. A scoping review of the UTROSCT case report present in the literature has been conducted, and 63 articles were found, of which 45 were considered for the 66 clinical cases examined. At the time of diagnosis, six metastatic localizations were found in 59 patients undergoing demolitive surgery (10.2%). Recurrences were diagnosed in 13/59 (22%) patients with multiple locations. A molecular study was performed in 18/66 cases (27.3%) and genetic alterations were found in 10/18 (55.6%) patients. UTROSCTs are considered rare uterine tumors, typically with a favorable prognosis, and are generally considered to have a good prognosis. But, from the review done, they may already manifest themselves at advanced stages, with the possibility of recurrences even at a distance. It would, therefore, be important to be able to define the most aggressive forms and, perhaps, molecular investigation with sequencing could help identify patients most at risk. Full article
(This article belongs to the Special Issue Update on Laparoscopic Management of Gynecologic Malignancies)
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