Sedation: Clinical Challenges and New Insights

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 864

Special Issue Editor


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Guest Editor
Department of Anesthesiology and Critical Care Medicine, Honickman Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA
Interests: sedation; airway management; anesthesia

Special Issue Information

Dear Colleagues,

Surgical procedures are constantly evolving, and many are being replaced with safer non-surgical interventions. Additionally, patients who are not candidates for aggressive surgical procedures benefit from less invasive options. Several such interventions have moved out of operating rooms to, unfortunately, lesser-equipped procedure rooms. Even though the field of gastroenterology leads in this area, other disciplines such as respiratory medicine, cardiology, radiology, and reproductive healthcare are making steady progress too.

The drug and device industry has responded to this uniquely dynamic landscape. Newer sedative agents such as remimazolam and opioids such as oliceridine are some of the tools currently available. The device market has evolved to address the oxygenation and ventilation issues faced by anesthesia providers tasked with providing sedation and anesthesia in unfamiliar areas.

In this Special Issue, we aim to publish articles that uniquely assist anesthesia providers, provide an overview of challenges, and suggest solutions.

Dr. Basavana Goudra
Guest Editor

Manuscript Submission Information

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Keywords

  • anesthesia
  • oxygenation
  • sedative agents
  • ventilation
  • airway management

Published Papers (1 paper)

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Research

10 pages, 1812 KiB  
Article
Predictors for Dexmedetomidine Requirement for Sedation under Regional Anesthesia
by Jun Ho Lee, Taehyeon Jung, Seonghoon Ko and Aram Doo
J. Clin. Med. 2024, 13(5), 1435; https://doi.org/10.3390/jcm13051435 - 1 Mar 2024
Viewed by 581
Abstract
(1) Background: This prospective observational study aimed to investigate the predictors affecting DMT requirements for sedation during regional anesthesia. (2) Method: A total of 108 patients who received regional anesthesia with intravenous DMT administration for orthopedic upper- or lower-extremity surgery were [...] Read more.
(1) Background: This prospective observational study aimed to investigate the predictors affecting DMT requirements for sedation during regional anesthesia. (2) Method: A total of 108 patients who received regional anesthesia with intravenous DMT administration for orthopedic upper- or lower-extremity surgery were enrolled. Following successful regional anesthesia, DMT was administered at a rate of 4 µg/kg/h until reaching loss of consciousness (LOC). The administered dose of DMT per body weight until LOC (DMTLOC; µg/kg) was evaluated. The infusion was maintained at a rate of 0.2–0.7 µg/kg/h during the surgery. At the end of surgery, the elapsed time to a BIS value of 90 (TBIS90; s) was recorded. Linear regression models were used to identify potential predictors of DMTLOC and TBIS90. (3) Results: One hundred patients were analyzed. There were negative relationships between DMTLOC and age (r = −0.297, p = 0.003) and DMTLOC and body mass index (BMI) (r = −0.425, p < 0.001), respectively. Multiple linear regression models revealed that both increasing age and BMI were significantly related to DMTLOC (r2 = 0.259, p < 0.001), but those variables showed no association with TBIS90. (4) Conclusions: The results of this study suggest that initial loading of DMT should be carefully titrated to minimize risk in elderly and obese surgical populations. Full article
(This article belongs to the Special Issue Sedation: Clinical Challenges and New Insights)
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