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Electropathology as the Foundation of Innovation in Diagnosis and Therapy...
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Electropathology as the Foundation of Innovation in Diagnosis and Therapy of Atrial Fibrillation

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Electrophysiology and Cardiovascular Physiology".

Deadline for manuscript submissions: closed (1 November 2023) | Viewed by 3702

Special Issue Editors

Prof. Dr. Natasja de Groot

E-Mail Website1 Website2
Guest Editor
Department of Cardiology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
Interests: cardiac mapping; mechanism of cardiac arrhythmias; signal recording- and processing technologies
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Bianca Brundel

E-Mail Website
Guest Editor
Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, 1081 HV Amsterdam, The Netherlands
Interests: molecular & cellular biology; proteostasis; pharmacology; atrial fibrillation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In this Special Issue, we focus on electropathology as the foundation of innovation in diagnosis and therapy of the most common cardiac arrhythmia atrial fibrillation (AF). Electropathology is defined as disorders in electrical wavefront propagation caused by structural and molecular abnormalities. However, how exactly electropathology contributes to AF initiation and perpetuation is, at present, not known.

In humans, electropathology can be measured non-invasively by, e.g., surface electrocardiograms or body surface mapping, and invasively by endo- or epicardial mapping procedures to identify target sites for ablation.

Electropathology can be unraveled by the quantification of electrical properties and correlating them with markers of molecular mechanisms using blood- or tissue samples. Profound knowledge of this so-called bio-electrical fingerprinting may serve to provide the foundation for innovation in the diagnosis and therapy of atrial fibrillation.

Prof. Dr. Natasja de Groot
Prof. Dr. Bianca Brundel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • conduction disorders
  • voltage mapping
  • complex fractionated electrograms
  • ablation approaches
  • biomarkers
  • molecular pathways
  • pathophysiology
  • proteostasis

Published Papers (2 papers)

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13 pages, 1666 KiB  
Review
Electro-Mechanical Alterations in Atrial Fibrillation: Structural, Electrical, and Functional Correlates
by Iraklis Pozios, Apostolos Ilias Vouliotis, Polychronis Dilaveris and Constantinos Tsioufis
J. Cardiovasc. Dev. Dis. 2023, 10(4), 149; https://doi.org/10.3390/jcdd10040149 - 31 Mar 2023
Cited by 3 | Viewed by 1793
Abstract
Atrial fibrillation is the most common arrhythmia encountered in clinical practice affecting both patients’ survival and well-being. Apart from aging, many cardiovascular risk factors may cause structural remodeling of the atrial myocardium leading to atrial fibrillation development. Structural remodelling refers to the development [...] Read more.
Atrial fibrillation is the most common arrhythmia encountered in clinical practice affecting both patients’ survival and well-being. Apart from aging, many cardiovascular risk factors may cause structural remodeling of the atrial myocardium leading to atrial fibrillation development. Structural remodelling refers to the development of atrial fibrosis, as well as to alterations in atrial size and cellular ultrastructure. The latter includes myolysis, the development of glycogen accumulation, altered Connexin expression, subcellular changes, and sinus rhythm alterations. The structural remodeling of the atrial myocardium is commonly associated with the presence of interatrial block. On the other hand, prolongation of the interatrial conduction time is encountered when atrial pressure is acutely increased. Electrical correlates of conduction disturbances include alterations in P wave parameters, such as partial or advanced interatrial block, alterations in P wave axis, voltage, area, morphology, or abnormal electrophysiological characteristics, such as alterations in bipolar or unipolar voltage mapping, electrogram fractionation, endo-epicardial asynchrony of the atrial wall, or slower cardiac conduction velocity. Functional correlates of conduction disturbances may incorporate alterations in left atrial diameter, volume, or strain. Echocardiography or cardiac magnetic resonance imaging (MRI) is commonly used to assess these parameters. Finally, the echocardiography-derived total atrial conduction time (PA-TDI duration) may reflect both atrial electrical and structural alterations. Full article
(This article belongs to the Special Issue Electropathology as the Foundation of Innovation in Diagnosis and Therapy of Atrial Fibrillation)
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16 pages, 770 KiB  
Systematic Review
Impact of Obesity on Atrial Electrophysiological Substrate
by Corina Schram Serban and Natasja M. S. de Groot
J. Cardiovasc. Dev. Dis. 2023, 10(8), 342; https://doi.org/10.3390/jcdd10080342 - 08 Aug 2023
Viewed by 1138
Abstract
(1) Background. Obesity is a well-established worldwide recognised risk factor for atrial fibrillation (AF). Prior review papers reported on the associations between obesity and AF development, but not on the relation between obesity and atrial electrophysiology. We therefore conducted a systematic review to [...] Read more.
(1) Background. Obesity is a well-established worldwide recognised risk factor for atrial fibrillation (AF). Prior review papers reported on the associations between obesity and AF development, but not on the relation between obesity and atrial electrophysiology. We therefore conducted a systematic review to describe the current knowledge of the characteristics of the atrial electrophysiological substrate in obese individuals and how they relate to the development of AF. (2) Methods. A search was conducted in Pubmed, Embase, and the Cochrane Library for publications evaluating the impact of obesity on atrial electrophysiology, electrical substrates, and their relation to the development of AF. (3) Results. A systematic literature search retrieved 477 potential publications based on the inclusion criteria; 76 full-text articles were selected for the present systematic review. The literature demonstrated that obesity predisposes to not only a higher AF incidence but also to more extensive atrial electrophysiological abnormalities increasing susceptibility to AF development. (4) Conclusion. Obesity may predispose to an overall increase in atrial electropathology, consisting of an increase in the slowing of the conduction, conduction block, low-voltage areas, and complex fractionated electrograms. To determine the impact of obesity-induced atrial electrical abnormalities on the long-term clinical outcome, further prospective studies are mandatory. Full article
(This article belongs to the Special Issue Electropathology as the Foundation of Innovation in Diagnosis and Therapy of Atrial Fibrillation)
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