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Mesenchymal Stem Cells and Their Therapeutic Applications
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Mesenchymal Stem Cells and Their Therapeutic Applications

A special issue of International Journal of Translational Medicine (ISSN 2673-8937).

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 3713

Special Issue Editor

Dr. Joan Oliva

E-Mail Website
Guest Editor
Department of Clinical Research, Emmaus Medical, Inc., Torrance, CA 90503, USA
Interests: stem cells; tissue regeneration; cell therapy; vitrification
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For the past two decades, the scientific and medical communities have focused on mesenchymal stem cells (MSCs) and their potential in treating diseases. MSCs can be isolated from many adult tissues, such as bone marrow, adipose tissue, umbilical cord, and dental pulp. MSCs are very promising for regenerating tissue through their differentiation potential (myoblast, epithelial cells, neurons, beta cells), decreasing inflammatory reaction, being used as anticancer therapies, and for delivering compounds to targeted organs (nucleic acids, exogenous or endogenous proteins, drugs). MSCs can be injected, transplanted or the injection of vesicles produced by the MSCs. Improvement of their therapeutical properties still needs a lot of effort to decrease the variability among studies and to increase the positive outcomes.

This Special Issue will accept for submission original research articles, reviews, and methods from leading scientists and clinicians around the world who are studying and developing MSC-based therapy. Topics of interest include therapeutic applications of MSCs, and more specifically cell/gene therapy, exosomes and extracellular vesicles, mechanism of action, bioprinting, GMP manufacturing, and regulatory guidelines.

Dr. Joan Oliva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Translational Medicine is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Review

13 pages, 719 KiB  
Review
Development of Indications for Endoscopic Spine Surgery: An Overview
by Fernanda Wirth, Esthael Cristina Querido Avelar Bergamaschi, Fábio da Silva Forti and João Paulo Machado Bergamaschi
Int. J. Transl. Med. 2023, 3(3), 321-333; https://doi.org/10.3390/ijtm3030023 - 29 Aug 2023
Cited by 1 | Viewed by 1394
Abstract
Endoscopic spine surgery (ESS) began more than 20 years ago as percutaneous endoscopic discectomy and has evolved to the present day. This technique offers many advantages, including a short hospital stay, minimal trauma and blood loss, the option of local or epidural anesthesia [...] Read more.
Endoscopic spine surgery (ESS) began more than 20 years ago as percutaneous endoscopic discectomy and has evolved to the present day. This technique offers many advantages, including a short hospital stay, minimal trauma and blood loss, the option of local or epidural anesthesia with sedation, a low rate of nosocomial infections, early recovery, and a quick return to work and daily activities. The success rate of this technique ranges from 83% to 90% in operated patients. This article aims to provide an overview of indications, versatility of the technique, advantages, contraindications and limitations, and also a reflection on the possible contraindications and limitations of the technique. Full article
(This article belongs to the Special Issue Mesenchymal Stem Cells and Their Therapeutic Applications)
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26 pages, 444 KiB  
Review
Recent Development of Biomaterials Combined with Mesenchymal Stem Cells as a Strategy in Cartilage Regeneration
by Jishizhan Chen
Int. J. Transl. Med. 2022, 2(3), 456-481; https://doi.org/10.3390/ijtm2030035 - 29 Aug 2022
Cited by 2 | Viewed by 1803
Abstract
Osteoarthritis leads to the progressive decay of articular cartilage. Due to its intrinsic avascular character, cartilage shows an inadequate capacity for regeneration. Cartilage loss may result in chronic pain, movement disorder and morbidity, which lack effective treatments except for joint replacement for late-stage [...] Read more.
Osteoarthritis leads to the progressive decay of articular cartilage. Due to its intrinsic avascular character, cartilage shows an inadequate capacity for regeneration. Cartilage loss may result in chronic pain, movement disorder and morbidity, which lack effective treatments except for joint replacement for late-stage osteoarthritis. To overcome this challenge, tissue engineering has emerged as a promising method. Scaffolds provide mechanical and biochemical support to stem cells that undergo differentiation and secrete a cartilage-specific matrix, and this strategy has been proven to have positive results. However, there is still a gap between the current strategy and perfection. Researchers are confronted with difficulties such as poor cell survival, insufficient differentiation, hypertrophy and endochondral calcification of neocartilage, and inadequate integration into the host tissue. The current research focuses on modifying scaffold parameters, including composition, stiffness, pore size, surface morphology, hydrophilicity and electric charge. On the other hand, cell regulation is another focus, including predifferentiation, gene editing, dynamic mechanical stimulus, and hypoxia. This review aims to provide a comprehensive discussion of existing challenges, scaffold types and properties, practical methods to improve chondrogenic potential and an outlook on future trends in cartilage bioengineering. Full article
(This article belongs to the Special Issue Mesenchymal Stem Cells and Their Therapeutic Applications)
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