Caenorhabditis elegans: A Model Organism for Human Health and Disease
Deadline for manuscript submissions: 30 June 2024 | Viewed by 77
The nematode Caenorhabditis elegans offers unique advantages that enable comprehensive research of the cellular and molecular mechanisms underlying human physiology, as well as devastating human pathologies, including neurodevelopmental diseases, age-associated neurodegenerative and neuromuscular disorders, stroke, and cancer.
The tiny worm proved pivotal in uncovering novel cellular mechanisms, including the Nobel prize-winning discoveries of programmed cell death, RNA interference, and the discovery and development of the Green Fluorescent Protein.
The evolutionary conservation between C. elegans and humans led to the establishment of robust C. elegans models of human diseases that closely mimic core disease-related phenotypes. These models allow studies from single-cell resolution to intra- and inter-tissue communication, whole-organism responses to internal and external stimuli, and large-scale genetic and pharmacological screenings. These are designed to elucidate the molecular mechanisms mediating pathogenesis and to identify and validate targets and drugs for emergent therapeutic interventions.
This Special Issue aims to provide an overview of the current research using C. elegans to study all aspects of human health and disease. It also celebrates the 50th anniversary of Sidney Brenner’s seminal paper on the identification of mutations that affect whole-animal behavior, priming a series of groundbreaking scientific discoveries.
Dr. Andreia Teixeira-Castro
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- human physiology
- human disease
- novel C. elegans methods
- novel C. elegans models
- disease models