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Caenorhabditis elegans: A Model Organism for Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 77

Special Issue Editor

Dr. Andreia Teixeira-Castro
E-Mail Website
Guest Editor
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal
Interests: C. elegans; disease model; neurodegenerative disorder

Special Issue Information

Dear Colleagues,

The nematode Caenorhabditis elegans offers unique advantages that enable comprehensive research of the cellular and molecular mechanisms underlying human physiology, as well as devastating human pathologies, including neurodevelopmental diseases, age-associated neurodegenerative and neuromuscular disorders, stroke, and cancer.

The tiny worm proved pivotal in uncovering novel cellular mechanisms, including the Nobel prize-winning discoveries of programmed cell death, RNA interference, and the discovery and development of the Green Fluorescent Protein.

The evolutionary conservation between C. elegans and humans led to the establishment of robust C. elegans models of human diseases that closely mimic core disease-related phenotypes. These models allow studies from single-cell resolution to intra- and inter-tissue communication, whole-organism responses to internal and external stimuli, and large-scale genetic and pharmacological screenings. These are designed to elucidate the molecular mechanisms mediating pathogenesis and to identify and validate targets and drugs for emergent therapeutic interventions.

This Special Issue aims to provide an overview of the current research using C. elegans to study all aspects of human health and disease. It also celebrates the 50th anniversary of Sidney Brenner’s seminal paper on the identification of mutations that affect whole-animal behavior, priming a series of groundbreaking scientific discoveries.

Dr. Andreia Teixeira-Castro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • human physiology
  • human disease
  • therapy
  • novel C. elegans methods
  • novel C. elegans models
  • disease models

Published Papers

This special issue is now open for submission.
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